platelet-derived endothelial cell growth factor

WordNet

1. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
2. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
3. become attached by or as if by the process of growth; "The tree trunks had grown together"
4. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
5. cause to grow or develop; "He grows vegetables in his backyard"
6. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
7. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
8. (pathology) an abnormal proliferation of tissue (as in a tumor)
9. a progression from simpler to more complex forms; "the growth of culture"
10. something grown or growing; "a growth of hair"
11. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
12. be a contributing factor; "make things factor into a companys profitability"
13. any of the numbers (or symbols) that form a product when multiplied together
14. an independent variable in statistics
15. anything that contributes causally to a result; "a number of factors determined the outcome"
16. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
17. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
18. small room in which a monk or nun lives (同)cubicle
19. a device that delivers an electric current as the result of a chemical reaction (同)electric cell
20. a room where a prisoner is kept (同)jail cell, prison cell
21. (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
22. any small compartment; "the cells of a honeycomb"
23. a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
24. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
25. a concept whose truth can be proved; "scientific hypotheses are not facts"
26. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
27. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"

PrepTutorEJDIC

1. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
2. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
3. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
4. (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
5. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/11/24 20:30:12」(JST)

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[Wiki en表示]

thymidine phosphorylase
Identifiers
EC number	2.4.2.4
CAS number	9030-23-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a thymidine phosphorylase (EC 2.4.2.4) is an enzyme that catalyzes the chemical reaction

thymidine + phosphate thymine + 2-deoxy-alpha-D-ribose 1-phosphate

Thus, the two substrates of this enzyme are thymidine and phosphate, whereas its two products are thymine and 2-deoxy-alpha-D-ribose 1-phosphate.

Thymidine phosphorylase is involved and used in the diagnosis of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is thymidine:phosphate deoxy-alpha-D-ribosyltransferase. Other names in common use include pyrimidine phosphorylase, thymidine-orthophosphate deoxyribosyltransferase, animal growth regulators, blood platelet-derived endothelial cell, growth factors, blood platelet-derived endothelial cell growth factor, deoxythymidine phosphorylase, gliostatins, pyrimidine deoxynucleoside phosphorylase, and thymidine:phosphate deoxy-D-ribosyltransferase. This enzyme participates in 3 metabolic pathways: purine metabolism, pyrimidine metabolism, and bladder cancer.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1AZY, 1OTP, 1TPT, 1UOU, 2J0F, and 2TPT.

References

• FRIEDKIN M, ROBERTS D (1954). "The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue". J. Biol. Chem. 207 (1): 245–56. PMID 13152099. 
• Zimmerman M and Seidenberg J (1964). "Deoxyribosyl transfer. I. Thymidine phosphorylase and nucleoside deoxyribosyltransferase in normal and malignant tissues". J. Biol. Chem. 239: 2618–2621. PMID 14235544. 
• Zimmerman M (1964). "Deoxyribosyl transfer. II. Nucleoside:pyrimidine deoxyribosyltransferase activity of three partially purified thymidine phosphorylases". J. Biol. Chem. 239: 2622–2627. PMID 14235545. 

UpToDate Contents

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• 1. 血管新生阻害剤の概要 overview of angiogenesis inhibitors
• 2. 巨核球の生物学と血小板の産生 megakaryocyte biology and the production of platelets
• 3. 血管内皮機能および血栓溶解療法の基本的メカニズム vascular endothelial function and fundamental mechanisms of fibrinolysis thrombolysis
• 4. 糸球体の免疫障害の機序 mechanisms of immune injury of the glomerulus
• 5. 高グレードの神経膠腫に対する実験的治療アプローチ experimental treatment approaches for high grade gliomas

English Journal

• Vascular Endothelial Growth Factor A Regulates the Secretion of Different Angiogenic Factors in Lung Cancer Cells.

• Frezzetti D1, Gallo M1, Roma C2, D'Alessio A1, Maiello MR1, Bevilacqua S1, Normanno N1, De Luca A1.
• Journal of cellular physiology.J Cell Physiol.2016 Jul;231(7):1514-21. doi: 10.1002/jcp.25243. Epub 2015 Nov 24.
• Vascular endothelial growth factor A (VEGFA) is one of the main mediators of angiogenesis in non-small cell lung cancer (NSCLC). Recently, it has been described an autocrine feed-forward loop in NSCLC cells in which tumor-derived VEGFA promoted the secretion of VEGFA itself, amplifying the proangiog
• PMID 26542886

• Counteractive effects of omentin-1 against atherogenesis†.

• Watanabe K1, Watanabe R1, Konii H1, Shirai R1, Sato K1, Matsuyama TA2, Ishibashi-Ueda H2, Koba S3, Kobayashi Y3, Hirano T4, Watanabe T5.
• Cardiovascular research.Cardiovasc Res.2016 May 1;110(1):118-28. doi: 10.1093/cvr/cvw016. Epub 2016 Jan 19.
• AIMS: Omentin-1, a novel adipocytokine expressed in visceral fat tissue, is negatively correlated with obesity, insulin resistance, and stable coronary artery disease (CAD). However, there have been no previous reports regarding the effects of omentin-1 on atherogenesis.METHODS AND RESULTS: This stu
• PMID 26790473

• The expanding role of neuropilin: regulation of transforming growth factor-β and platelet-derived growth factor signaling in the vasculature.

• Kofler N1, Simons M.
• Current opinion in hematology.Curr Opin Hematol.2016 May;23(3):260-7. doi: 10.1097/MOH.0000000000000233.
• PURPOSE OF REVIEW: Long recognized for its role in regulation of vascular endothelial growth factor signaling, neuropilin (Nrp)1 has emerged as a modulator of additional signaling pathways critical for vascular development and function. Here we review two novel functions of Nrp1 in blood vessels: re
• PMID 26849476

Japanese Journal

• 血小板に魅せられて

• 岡野 こずえ
• 山口医学 = Yamaguchi medical journal 64(1), 5-9, 2015-02
• … 我々は血液中の多様なMPの中でもaPLT-MPを特異的に定量出来る高感度ELISAを開発し,種々の血栓症患者を対象に臨床的有用性の検討に取り組んでいる.さらに,aPLT-MP以外のMP検出法を開発し,各細胞由来MPが血栓形成作用や炎症促進作用にどのように関与しているかをaPLT-MPとの比較で明らかにする研究を行っている.今回はその研究経過について報告する.A platelet is a discoid and anucleate microcytic cell of diameter …
• NAID 120005601210

• New Biodegradable Implant Material Containing Hydrogel with Growth Factors of Lyophilized PRF in Combination with an nHA/PLGA Scaffold

• , , , , , ,
• Journal of Hard Tissue Biology 24(1), 54-60, 2015
• … Platelet-rich fibrin(PRF)is second generation platelet concentration that contains growth factors such as transforming growth factor-β1 (TGF-β1), platelet derived growth factor-AB (PDGF-AB), and insulin-like growth factor-I (IGF-I). …
• NAID 130004848443

• Efficacy of the controlled release of concentrated platelet lysate from a collagen/gelatin scaffold for dermis-like tissue regeneration.

• Ito Ran,Morimoto Naoki,Pham Liem Hieu,Taira Tsuguyoshi,Kawai Katsuya,Suzuki Shigehiko
• Tissue engineering. Part A 19(11-12), 1398-1405, 2013-04
• … Introduction: A collagen/gelatin scaffold (CGS) can provide a sustained release of basic fibroblast growth factor (bFGF), which promotes wound healing. … One potential alternative to bFGF is platelet lysate (PL), a safe and easily attainable source of a wide range of growth factors necessary for tissue repair. … We measured growth factors in PL. …
• NAID 120005244932

Related Links

• ECGF1 - Wikipedia, the free encyclopedia

Platelet-derived endothelial cell growth factor (ECGF1) is an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell specificity acting ...

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★リンクテーブル★

リンク元	「グリオスタチン」「血小板由来血管内皮細胞増殖因子」
関連記事	「derive」「grow」「fact」「factor」「cell growth」

「グリオスタチン」

　　[★]

英

gliostatin

同

血小板由来血管内皮細胞増殖因子 platelet-derived endothelial cell growth factor, PD-ECGF

「血小板由来血管内皮細胞増殖因子」

　　[★]

英

platelet-derived endothelial cell growth factor, PD-ECGF

関

グリオスタチン

「derive」

　　[★]

• vt.

• 由来する

同

stem

• 由来する、派生する、引き出す

関

borne、come from、descend、draw、educe、elicit、stem

　 　 　 　 　

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「cell growth」

　　[★]

• 細胞増殖

関

cell expansion、cell multiplication、cell proliferation、cellular proliferation