WordNet

(biology) any agency bringing about activation; a molecule that increases the activity of an enzyme or a protein that increases the production of a gene product in DNA transcription
an inactive form of plasmin that occurs in plasma and is converted to plasmin by organic solvents

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/14 15:31:00」(JST)

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Fibrinolysis

A plasminogen activator is a serine protease which converts plasminogen to plasmin, thus promoting fibrinolysis.

Types include:

Tissue plasminogen activator
Urokinase

It is inhibited by plasminogen activator inhibitor-1 and plasminogen activator inhibitor-2.

This drug article relating to the blood and blood forming organs is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 血栓溶解異常による血栓性および出血性疾患 thrombotic and hemorrhagic disorders due to abnormal fibrinolysis
2. 線溶マーカーおよび心血管リスク fibrinolytic markers and cardiovascular risk
3. 止血の概要 overview of hemostasis
4. 静脈血栓症の原因の概要 overview of the causes of venous thrombosis
5. 血管内皮機能および血栓溶解療法の基本的メカニズム vascular endothelial function and fundamental mechanisms of fibrinolysis thrombolysis

English Journal

Reperfusion Therapy in the Acute Management of Ischemic Stroke.

Lin MP1, Sanossian N2.
Cardiology clinics.Cardiol Clin.2015 Feb;33(1):99-109. doi: 10.1016/j.ccl.2014.09.009.
Reperfusion, or restoration of blood flow, is an effective means of reducing disability in the setting of acute stroke. Reperfusion therapies, such as intravenous thrombolysis or endovascular and interventional procedures, fit within the existing stroke system of care. There are currently 4 devices
PMID 25439334

Expression and anticancer activity analysis of recombinant human uPA1‑43-melittin.

Su M1, Chang W1, Cui M1, Lin Y1, Wu S1, Xu T1.
International journal of oncology.Int J Oncol.2015 Feb;46(2):619-26. doi: 10.3892/ijo.2014.2750. Epub 2014 Nov 13.
The present study is focused on expression of a target fusion protein which can be used in ovarian cancer target therapy. It aimed to construct human urokinase-type plasminogen activator (uPA)1‑43-melittin eukaryotic expression vector to express recombinant human uPA1‑43-melittin (rhuPA1‑43-me
PMID 25394558

Predictive value of plasma biomarkers for mortality and organ failure development in patients with acute respiratory distress syndrome.

Cartin-Ceba R1, Hubmayr RD2, Qin R3, Peters S2, Determann RM4, Schultz MJ4, Gajic O2.
Journal of critical care.J Crit Care.2015 Feb;30(1):219.e1-7. doi: 10.1016/j.jcrc.2014.09.001. Epub 2014 Sep 6.
PURPOSE: To evaluate the predictive value of 6 different biomarkers in the development of multiple-organ failure (MOF) and mortality in a contemporary prospective cohort of acute respiratory distress syndrome (ARDS).METHODS: Patients with ARDS admitted to a tertiary referral center during an 8-month
PMID 25261280

Japanese Journal

症例報告左房粘液腫による心原性脳塞栓症の1例

畑山さや香,緒方利安,大川将和 [他]
Brain and nerve : 神経研究の進歩 64(10), 1175-1179, 2012-10-00
NAID 40019457094

Observational Investigation of Thrombolysis With the Tissue-Type Plasminogen Activator Monteplase for Acute Pulmonary Embolism in Japan

NIWA Akihiro,NAKAMURA Mashio,HARADA Natsumi,MUSHA Takashi
Circulation journal : official journal of the Japanese Circulation Society 76(10), 2471-2480, 2012-09-25
… Background: In Japan, the safety and efficacy of thrombolytic therapy using tissue-type plasminogen activator for acute pulmonary embolism (PE) in the real world remain unclear. …
NAID 10030875222

循環器内科医が遭遇する,大動脈解離による脳梗塞 (特集循環器内科医が遭遇する脳梗塞)

斎藤こずえ
循環器内科 72(3), 338-342, 2012-09-00
NAID 40019452295

「血管内皮」

Plasminogen
	PDB rendering based on 4dur.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1B2I, 1BML, 1BUI, 1CEA, 1CEB, 1DDJ, 1HPJ, 1HPK, 1I5K, 1KI0, 1KRN, 1L4D, 1L4Z, 1PK4, 1PKR, 1PMK, 1QRZ, 1RJX, 2DOH, 2DOI, 2KNF, 2L0S, 2PK4, 3UIR, 4A5T, 4CIK, 4DCB, 4DUR, 4DUU, 5HPG
Identifiers
Symbols	PLG ; DKFZp779M0222
External IDs	OMIM: 173350 MGI: 97620 HomoloGene: 55452 ChEMBL: 1801 GeneCards: PLG Gene
EC number	3.4.21.7
Gene ontology
Molecular function	• serine-type endopeptidase activity; • receptor binding; • protein binding; • serine-type peptidase activity; • protein domain specific binding; • apolipoprotein binding;
Cellular component	• extracellular region; • extracellular space; • plasma membrane; • cell surface; • platelet alpha granule lumen; • extrinsic component of external side of plasma membrane; • extracellular exosome; • blood microparticle;
Biological process	• platelet degranulation; • proteolysis; • blood coagulation; • negative regulation of cell proliferation; • negative regulation of cell-substrate adhesion; • extracellular matrix disassembly; • platelet activation; • extracellular matrix organization; • fibrinolysis; • cellular protein metabolic process; • tissue remodeling; • negative regulation of fibrinolysis; • positive regulation of fibrinolysis; • negative regulation of cell-cell adhesion mediated by cadherin;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

　　[★]

英: endothelium (Z)
関: 血管

Table 10-1. Endothelial Cell Properties and Functions

Maintenance of Permeability Barrier

Elaboration of Anticoagulant, Antithrombotic, Fibrinolytic Regulators

prostacyclin

thrombomodulin

heparin-like molecules

plasminogen activator

Elaboration of Prothrombotic Molecules

Von Willebrand factor

Tissue factor

Plasminogen activator inhibitor

Extracellular Matrix Production (Collagen, Proteoglycans)

Modulation of Blood Flow and Vascular Reactivity

Vasconstrictors: endothelin, ACE

Vasodilators: NO, prostacyclin

Regulation of Inflammation and Immunity

IL-1, IL-6, chemokines

Adhesion molecules: VCAM-1, ICAM, E-selectin P-selectin

Histocompatibility antigens

Regulation of Cell Growth

Growth stimulators: PDGF, CSF, FGF

Growth inhibitors: heparin, TGF-β

Oxidation of LDL

「プラスミノーゲンアクチベーター」

　　[★]

英: plasminogen activator, PA
関: プラスミノーゲン活性化因子、プラスミノゲン

[show details]

プラスミノーゲンアクチベーター : 約 32,400 件
プラスミノゲンアクチベーター : 約 10,900 件

「プラスミノゲンアクチベーター」

　　[★]

英: plasminogen activator PA
同: プラスミノゲン活性化因子
関

「plasminogen activator inhibitor 1」

　　[★]

プラスミノーゲン活性化因子インヒビター1、プラスミノーゲンアクチベーターインヒビター1

関: PAI-1

「plasminogen activator inhibitor-1」

　　[★] プラスミノゲンアクチベータインヒビター-1

「defective plasminogen activator release」

　　[★] プラスミノゲンアクチベーター放出障害

「activator」

　　[★]

n.

活性化因子、活性化薬、活性化剤、賦活薬、活性化物質、アクチベーター、アクティベーター

リンク元	「血管内皮」「プラスミノーゲンアクチベーター」「プラスミノゲンアクチベーター」
拡張検索	「plasminogen activator inhibitor 1」「plasminogen activator inhibitor-1」「defective plasminogen activator release」
関連記事	「activator」

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