English Journal

[Histamine reduction by means of oncolytically active and oncolytically non-active clostridial strains (author's transl)].

Möse JR, Moser M, Fischer G.AbstractSpores and vegetative forms of oncolytically active and oncolytically non-active clostridial strains were tested for histamine reducing activity (isolated ileum of guinea pig used for testing, waterbath method acc. to Magnus, Fig. 1). Culture media and the washed intact material did not show any or only very little effectiveness. On the other hand the fractionated, charges diminished histamine standard solutions except for very little remaining activity in the case of all strains. This effect was stronger in vegetative forms than in spores (Fig. 2). The histamine effect on the isolated organ was generally increased by means of culture media as well as by the washed intact material. In this respect, preparations of non-lytic strains showed a slightly higher effectiveness than preparations of lytic clostridial strains (Fig. 2). It was shown in earlier investigations (cf. bibliography) that the charges of clostridial strains decompose plasmakinin (synthetic bradykinin) at varying rates. Reduction of histamine activity by means of clostridia could lead to a decrease of the microcirculation and capillary-permeability in the tumor tissue (as hypothesized for bradykinin) and thereby favour its disintegration.
Zentralblatt für Bakteriologie. 1. Abt. Originale. A: Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie.Zentralbl Bakteriol A.1980;246(4):541-9.
Spores and vegetative forms of oncolytically active and oncolytically non-active clostridial strains were tested for histamine reducing activity (isolated ileum of guinea pig used for testing, waterbath method acc. to Magnus, Fig. 1). Culture media and the washed intact material did not show any or
PMID 7424244

Plasmakinin system in alloxan diabetic rats.

Ottlecz A, Koltai M, Gecse A.
Advances in the biosciences.Adv Biosci.1978 Jul 22;17:57-63.
PMID 755708

[Importance of chemical mediators for the pathogenesis and treatment of hemicrania].

Berde B, Fanchamps A.AbstractThe vascular mechanism of migraine attacks--intracranial vasoconstriction during the prodromal stage and passive vasodilatation of extracranial arteries during the painful phase--has been confirmed by modern methods. In addition, number of humoral factors--plasmakinin, serotonin, histamine--intervene in the chain of events that culminates in migraine headache. In addition to these three humoral mediators, the part played by tyramine in migraine of alimentary origin, the precipitating effect of oestrogen decrease in menstrual migraine and the hypothetical role of prostaglandins and prolactin are discussed. The multifactorial mechanism of migraine accounts for the very variable profiles of effective anti-migraine drugs.
Minerva medica.Minerva Med.1976 Jun 23;67(31):1991-8.
The vascular mechanism of migraine attacks--intracranial vasoconstriction during the prodromal stage and passive vasodilatation of extracranial arteries during the painful phase--has been confirmed by modern methods. In addition, number of humoral factors--plasmakinin, serotonin, histamine--interven
PMID 1084500

Japanese Journal

126.眼疾患におけるキニン系の動態 : 特にベーチェット病のキニンについて(ベーチェット病)

宮永嘉隆,三村康男
アレルギー 21(2), 167, 1972-02-28
NAID 110002408945

8.痛みと凝固線溶とは関係があるか(第4回プラスマキニン研究会)

安部英,清原迪夫,池森享介,奥村,藤井
アレルギー 19(8), 634-637, 655, 1970-08-30
… Eisen proposed a schema for activation mechanism of plasmakinin and its allied materials in 1966, in which plasmin should play active role, and in our cases pain sensation and elevated capillary permeability were invited by the ischemic muscle contraction test, but the participation of fibrinolysis agents was not proved so eloquently. …
NAID 110002408361