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「neoplasm of plasma cells (usually in bone marrow)」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/03 07:51:27」(JST)

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  • Latitude gradients for lymphoid neoplasm subtypes in Australia support an association with ultraviolet radiation exposure.
  • van Leeuwen MT, Turner JJ, Falster MO, Meagher NS, Joske DJ, Grulich AE, Giles GG, Vajdic CM.SourceAdult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, The University of New South Wales, Sydney, Australia.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2013 Aug 15;133(4):944-51. doi: 10.1002/ijc.28081. Epub 2013 Mar 4.
  • Given the uncertainty surrounding solar ultraviolet radiation (UVR) exposure and risk of lymphoid neoplasms, we performed an ecological analysis of national Australian data for incident cases diagnosed between 2002 and 2006. Subtype-specific incidence was examined by latitude band (<29°S, 29-36�
  • PMID 23382012
  • Solitary plasmacytoma: 10 years' experience at All India Institute of Medical Sciences, New Delhi.
  • Baghmar S, Mohanti BK, Sharma A, Kumar L, Prakash G, Kumar S, Gupta R, Kumar R, Raina V.SourceDepartment of Medical Oncology, Dr BRA IRCH, AIIMS , New Delhi , India.
  • Leukemia & lymphoma.Leuk Lymphoma.2013 Aug;54(8):1665-70. doi: 10.3109/10428194.2012.750725. Epub 2012 Dec 24.
  • Abstract Plasma cell dyscrasias account for 1% of all malignancies and 10% of hematological malignancies. About 5% of patients with a plasma cell dyscrasia present with either solitary bone plasmacytoma (SBP) or, less commonly, a soft tissue mass, extramedullary plasmacytoma (EMP) of monoclonal plas
  • PMID 23163525
  • The Composite Cytokine p28/Cytokine-Like Factor 1 Sustains B Cell Proliferation and Promotes Plasma Cell Differentiation.
  • Tormo AJ, Meliani Y, Beaupré LA, Sharma M, Fritz JH, Elson G, Crabé S, Gauchat JF.SourceDépartement de Pharmacologie, Université de Montréal, Montréal, Québec H3T 1J4, Canada;
  • Journal of immunology (Baltimore, Md. : 1950).J Immunol.2013 Jul 8. [Epub ahead of print]
  • IL-27 is an APC-derived IL-6/IL-12 family composite cytokine with multiple functions such as regulation of Th1, Th17, and regulatory T cell differentiation, B cell proliferation, and Ig class switching. The IL-27 complex is formed by the association of the cytokine p28 with the soluble cytokine rece
  • PMID 23836062


  • 臨床室 肋骨に生じた孤立性形質細胞腫の1例
  • 尾崎 律郎,北村 公一,神保 俊介 [他]
  • 整形外科 63(6), 531-533, 2012-06
  • NAID 40019338840
  • 下顎骨を含めて異時性に多発した形質細胞腫の1例
  • 佐藤 翔,中井 徹,越沼 伸也 [他]
  • 日本口腔外科学会雑誌 58(5), 302-306, 2012-05
  • NAID 40019334832


Plasmacytoma refers to a malignant plasma cell tumor growing within soft tissue or within the axial skeleton. There are three distinct groups of plasmacytoma defined by the International Myeloma Working Group: solitary ...
plasmacytoma 【名】《病理》形質細胞腫、骨髄腫 - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。



リンク元単クローン性免疫グロブリン血症」「形質細胞腫」「full-blown」「plasma cell tumor」「plasmocytoma
拡張検索solitary plasmacytoma



monoclonal gammopathy MG
単クローン性高免疫グロブリン血症 monoclonal hyperimmunoglobulinemia単クローン性高ガンマグロブリン血症 単クローン性高γグロブリン血症 monoclonal hypergammaglobulinemiaM蛋白血症 M proteinemia
  • 080626 免疫学

Clasification WCH.2566

  • monoclonal gammopathy of undetermined significance
  • benign(IgG, IgA, IgD, IgM, and, rarely, free light chains)
  • associated with neoplasms of cell types not known to produce M-proteins
  • biclonal gammopathy
  • idiopathic Nence Jones proteinuria
  • malignant monoclonal gammopathies
  • overt multiple myeloma
  • smoldering multiple myeloma
  • plasma cell leukemia
  • nonsecretory myeloma
  • IgD myeloma
  • POEMS: polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes (osteosclerotic myeloma)
  • plasmacytoma
  • solitary plsmacytoma of bone
  • extramedullary plamacytoma
  • malignant lymphoproliferative disorders
  • heavy chain diseases
  • γ heary chain disease
  • α heary chain disease
  • μ heary chain disease
  • amyloidosis
  • primary amyloidosis
  • with multiple myeloma (secondary, localized, and familial amyloidosis with no M-protein)

frequency WCH.2567

  • monoclonal gammopathy of underteermined significance: 62%
  • multiple myeloma: 16%
  • amyloidosis: 8%
  • lymphoproliferative: 3%
  • smoldering multiple myeloma: 4%
  • solitary or extramedullary: 1%
  • Walderstrom maroglobulinemia: 3%
  • other: 3%





  • 形質細胞が単クローン性に増加し、骨格/軟組織に孤立性の腫瘤を形成したもの


  • 髄内性形質細胞腫 intramedullary plasmacytoma
  • 髄外性形質細胞腫 extramedullary plasmacytoma
  • 上気道(副鼻腔、鼻咽頭、喉頭)に病変を形成することが多い


solitary plasmacytoma of bone, diagnostic criteria HIM.704

  • no M protein in serum and/or urine. ← M蛋白がない(微量はあってもよい, modestly elevated M proteins are demonstrable in some of these patients.(PBT.454))
  • single area of bone destruction due to clonal plasma cells.
  • bone marrow not consistent with multiple myeloma.
  • normal skeletal survey (and MRI of spine and pelvis if done).
  • no related organ or tissue impairment (no end organ damage other than solitary bone lesion).

extramedullary plasmacytoma

治療 WCH.2621

  • local radiatin therapy
  • adjuvant chemotherapy is not recommended

予後 WCH.2621

  • local filure rate: 7%
  • mutifocal extramedullary replapse: 13%
  • classic myeloma develop: 15%
  • 10-year disease-free survival: 70-80%


  • 骨格にできた孤立性の形質細胞腫はふつう他に潜伏性の病変があり、多くは5-10年で多発性骨髄腫に移行する
  • 髄外形質細胞腫は広がることは比較的少なく局所的な切除で治癒する。



  • adj.
  • (花が)満開の。成熟しきった。(病気が)病状のもっとも悪化した、進行した。(帆が)いっぱいに風をはらんだ。あらゆる特性を備えた、本格的な、まっとうな
Those with solitary skeltal plasmacytomas usually have occult disease elsewhere, and most develop full-blown multiple myeloma over a period of 5 to 10 years.
end stage, terminal, terminal stage, terminally

WordNet   license wordnet

「having or displaying all the characteristics necessary for completeness; "a full-blown financial crisis"」

PrepTutorEJDIC   license prepejdic

「(花が)満開の / 十分に発達した」

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「fully ripe; at the height of bloom; "a full-blown rose"」

plasma cell tumor」



plasma cell neoplasmplasmacytomaplasmocytoma



plasma cell tumorplasmacytoma

solitary plasmacytoma」

  [★] 単発性骨髄腫単発性形質細胞腫