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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/04/06 11:11:37」(JST)

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Pirarubicin (INN) is an anthracycline drug.

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1. 筋層非浸潤性膀胱癌の治療 treatment of non muscle invasive bladder cancer

English Journal

Prospective Randomized Phase II Trial of a Single Early Intravesical Instillation of Pirarubicin (THP) in the Prevention of Bladder Recurrence After Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma: The THP Monotherapy Study Group Trial.

Ito A, Shintaku I, Satoh M, Ioritani N, Aizawa M, Tochigi T, Kawamura S, Aoki H, Numata I, Takeda A, Namiki S, Namima T, Ikeda Y, Kambe K, Kyan A, Ueno S, Orikasa K, Katoh S, Adachi H, Tokuyama S, Ishidoya S, Yamaguchi T, Arai Y.SourceAkihiro Ito, Ichiro Shintaku, Kazuhiko Orikasa, Shigeto Ishidoya, Takuhiro Yamaguchi, and Yoichi Arai, Tohoku University Graduate School of Medicine; Naomasa Ioritani and Masataka Aizawa, Sendai Shakai Hoken Hospital; Takashige Namima and Yoshihiro Ikeda, Tohoku Rosai Hospital, Sendai; Makoto Satoh, Sen-en General Hospital, Tagajo; Tatsuo Tochigi, Sadafumi Kawamura, and Hiroshi Aoki, Miyagi Cancer Center, Natori; Isao Numata, Atsushi Takeda, and Shunichi Namiki, Osaki Citizen Hospital, Osaki; Koichi Kambe, Senseki Hospital, Higashimatsushima; Atsushi Kyan, Shirakawa Kosei General Hospital, Shirakawa; Seiji Ueno, Kesennuma City Hospital, Kesennuma; Shinnosuke Katoh, Ogachi Central Hospital, Yuzawa; Hisanobu Adachi, Iwate Prefectural Iwai Hospital, Ichinoseki; and Satoru Tokuyama, Iwaki Kyoritsu General Hospital, Iwaki, Japan.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.J Clin Oncol.2013 Mar 4. [Epub ahead of print]
PURPOSEWe evaluated the efficacy of a single early intravesical instillation of pirarubicin (THP) in the prevention of bladder recurrence after nephroureterectomy for upper urinary tract urothelial carcinoma (UUT-UC).Patients And methodsFrom December 2005 to November 2008, 77 patients clinically dia
PMID 23460707

Clinical importance of human herpes virus-8 and human immunodeficiency virus infection in primary effusion lymphoma.

Kumode T, Ohyama Y, Kawauchi M, Yamaguchi T, Miyatake JI, Hoshida Y, Tatsumi Y, Matsumura I, Maeda Y.SourceDepartment of Hematology.
Leukemia & lymphoma.Leuk Lymphoma.2013 Jan 24. [Epub ahead of print]
Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma that usually develops in immunosuppressed patients infected with human herpes virus-8 (HHV-8) in conjunction with human immunodeficiency virus (HIV) infection. However, there are several reports of HHV-8-related HIV-negative case
PMID 23278643

New structure-activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR).

Orlandi F, Coronnello M, Bellucci C, Dei S, Guandalini L, Manetti D, Martelli C, Romanelli MN, Scapecchi S, Salerno M, Menif H, Bello I, Mini E, Teodori E.SourceDipartimento di Scienze Farmaceutiche, Università di Firenze, via Ugo Schiff 6, 50019 Sesto Fiorentino, FI, Italy.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2013 Jan 15;21(2):456-65. doi: 10.1016/j.bmc.2012.11.019. Epub 2012 Nov 24.
As a continuation of previous research on a new series of potent and efficacious P-gp-dependent multidrug resistant (MDR) reversers with a N,N-bis(cyclohexanol)amine scaffold, we have designed and synthesized several analogs by modulation of the two aromatic moieties linked through ester functions t
PMID 23245571

Japanese Journal

腎盂尿管癌術後,ピラルビシン膀胱注入療法による術後膀胱内再発予防効果の検討

長島政純,荒木あずみ,柳澤昌宏 [他],小宮敦,高野哲三,村上貴之,池田伊知郎
泌尿器科紀要 = Acta urologica Japonica 59(4), 213-216, 2013-04
… We retrospectively evaluated 23 patients who had been administered pirarubicin by intravesical instillation once weekly for 5 weeks, after undergoing surgery for upper urinary tract cancer between May 2003 and October 2008. … We compared their clinical records with those of 19 patients with upper urinary tract cancer subjected to nephroureterectomy between 1998 and 2008, and who did not receive intravesical instillation of pirarubicin. …
NAID 120005244621

生体腎移植後,尿路上皮癌を発症した1例

中澤成晃,今村亮一,林拓自 [他],山本致之,谷川剛,藤田和利,細見昌弘,伏見博彰,山口誓司
泌尿器科紀要 = Acta urologica Japonica 59(2), 117-120, 2013-02
… Cystoscopy findings revealed multiple bladder tumors, and transurethral resection of bladder tumor (TUR-BT) followed by intravesical instillation of pirarubicin was performed. …
NAID 120005244233

Diffuse Large B-Cell Lymphoma with Mass Lesions of Skull Vault and Ileocecum

Kosugi Shigeki,Kume Masaaki,Sato Joji,Sakuma Ikuo,Moroi Junta,Izumi Keiichi,Sato Yasukazu,Nakamura Naoya,Takahashi Masatomo,Miura Ikuo
Journal of Clinical and Experimental Hematopathology 53(3), 215-219, 2013
… She was treated by irradiation (45 Gy) of the mass on the parietal bone and with rituximab, pirarubicin, cyclophosphamide, and vincristine. …
NAID 130003383996

Related Pictures

★リンクテーブル★

リンク元	「ピラルビシン」「THP」

「ピラルビシン」

Pirarubicin
Systematic (IUPAC) name
	(3S)-3-glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-α-L-lyxo-hexopyranoside
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Identifiers
CAS number	72496-41-4
ATC code	L01DB08
PubChem	CID 3033521
UNII	D58G680W0G
KEGG	D01885
ChEMBL	CHEMBL40848
Synonyms	(9S)-7-[(2R,4S,5S,6S)-4-amino-6-methyl-5-[(2R)-oxan-2-yl]oxyoxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
Chemical data
Formula	C32H37NO12
Mol. mass	627.63 g/mol
SMILES	eMolecules & PubChem
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