WordNet

of or consistent with an organisms normal functioning; "physiologic functions"; "physiological processes" (同)physiological

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VEGF over-expression in skeletal muscle induces angiogenesis by intussusception rather than sprouting.

Gianni-Barrera R, Trani M, Fontanellaz C, Heberer M, Djonov V, Hlushchuk R, Banfi A.SourceCell and Gene Therapy, Department of Biomedicine and Department of Surgery, Basel University Hospital, Switzerland.
Angiogenesis.Angiogenesis.2013 Jan;16(1):123-36. doi: 10.1007/s10456-012-9304-y. Epub 2012 Sep 9.
Therapeutic over-expression of vascular endothelial growth factor (VEGF) can be used to treat ischemic conditions. However, VEGF can induce either normal or aberrant angiogenesis depending on its dose in the microenvironment around each producing cell in vivo, which limits its clinical usefulness. T
PMID 22961440

Increased shear stress inhibits angiogenesis in veins and not arteries during vascular development.

Chouinard-Pelletier G, Jahnsen ED, Jones EA.SourceDepartment of Chemical Engineering, McGill University, Montreal, QC, Canada.
Angiogenesis.Angiogenesis.2013 Jan;16(1):71-83. doi: 10.1007/s10456-012-9300-2. Epub 2012 Sep 2.
Vascular development is believed to occur first by vasculogenesis followed by angiogenesis. Though angiogenesis is the formation of new vessels, we found that vascular density actually decreases during this second stage. The onset of the decrease coincided with the entry of erythroblasts into circul
PMID 22941228

The vascular-disrupting agent combretastatin impairs splitting and sprouting forms of physiological angiogenesis.

Hussain A, Steimle M, Hoppeler H, Baum O, Egginton S.SourceDepartment of Physiology, University of Birmingham Medical School, Birmingham, UK.
Microcirculation (New York, N.Y. : 1994).Microcirculation.2012 May;19(4):296-305. doi: 10.1111/j.1549-8719.2012.00160.x.
OBJECTIVE: Vascular-disrupting agents like combretastatin (CA-4-P), used to attenuate tumor blood flow in vivo, exert anti-mitotic and anti-migratory effects on endothelial cells in vitro. We tested whether anti-vascular or anti-angiogenic effects of CA-4-P are evident with physiological angiogenesi
PMID 22236138

丸山徹,永野純,眞崎義憲 [他],入江正洋,上園慶子,Maruyama Toru,Nagano Jun,Masaki Yoshinori,Irie Masahiro,Uezono Keiko,マルヤマトオル,ナガノジュン,マサキヨシノリ,イリエマサヒロ,ウエゾノケイコ
健康科学 31, 99-103, 2009-00-00
… However, RBBB in young generation is mainly based on the physiologic right ventricular volume overload leading to stretch of right bundle branch. … Physiologic respiratory splitting was heard in their second heart sounds, suggesting that congenital cardiac anomalies are unlikely. …
NAID 120001177104

Segall Harold N. [他],SHARP A.
Ｊａｐａｎｅｓｅ　Ｈｅａｒｔ　Ｊｏｕｒｎａｌ 8(5), 468-486, 1967
… Splitting of the first sound occurs rarely in both right and left bundle branch block and is most likely to be detected at the apex. … splitting of the second sound occurred in about 40% of Series A (1926-1952) and 80% of Series B (1952-1963) at the left border of the sternum near the fourth inter costal space with the patient in the sitting position. … In Series B, auscultation with the patient in the dorsal recumbent posture, splitting was detected in only 60% at this area. …
NAID 130000769035

Heart Sounds and Murmurs in Rheumatic Valvular Aortic Stenosis:A Physiologic Approach Systemic Review and Personal Contribution

Calo A.A.
Ｊａｐａｎｅｓｅ　Ｈｅａｒｔ　Ｊｏｕｒｎａｌ 3(4), 299-312, 1962
… Accentuation and splitting are usually due to marked exaggeration of the last component of the 1st sound (early systolic click, ejection sound).The systolic murmur, practically constant, may be alternans. …
NAID 130000765259