WordNet

the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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1. 膜性腎症の原因および診断 causes and diagnosis of membranous nephropathy
2. 特発性膜性腎症の治療 treatment of idiopathic membranous nephropathy
3. 糸球体の免疫障害の機序 mechanisms of immune injury of the glomerulus
4. 膜性腎症と腎移植 membranous nephropathy and renal transplantation
5. 膜性ループス腎炎の臨床的特徴および治療 clinical features and therapy of membranous lupus nephritis

Aberrant methylation of the M-type phospholipase A2 receptor gene in leukemic cells.

Menschikowski M, Platzbecker U, Hagelgans A, Vogel M, Thiede C, Schönefeldt C, Lehnert R, Eisenhofer G, Siegert G.AbstractABSTRACT: BACKGROUND: The M-type phospholipase A2 receptor (PLA2R1) plays a crucial role in several signaling pathways and may act as tumor-suppressor. This study examined the expression and methylation of the PLA2R1 gene in Jurkat and U937 leukemic cell lines and its methylation in patients with myelodysplastic syndrome (MDS) or acute leukemia.
BMC cancer.BMC Cancer.2012 Dec 5;12(1):576. [Epub ahead of print]
ABSTRACT: BACKGROUND: The M-type phospholipase A2 receptor (PLA2R1) plays a crucial role in several signaling pathways and may act as tumor-suppressor. This study examined the expression and methylation of the PLA2R1 gene in Jurkat and U937 leukemic cell lines and its methylation in patients with my
PMID 23217014

Recurrent Membranous Nephropathy in an Allograft Caused by IgG3κ Targeting the PLA2 Receptor.

Debiec H, Hanoy M, Francois A, Guerrot D, Ferlicot S, Johanet C, Aucouturier P, Godin M, Ronco P.SourceINSERM Unit 702, Hôpital Tenon, 4 rue de la Chine, 75020 Paris, France. pierreronco@yahoo.fr.
Journal of the American Society of Nephrology : JASN.J Am Soc Nephrol.2012 Dec;23(12):1949-54. doi: 10.1681/ASN.2012060577. Epub 2012 Nov 2.
Up to 80% of patients with idiopathic membranous nephropathy have non-complement-fixing IgG4 autoantibodies to the phospholipase A2 receptor (PLA2R). Membranous nephropathy recurs in approximately 40% of patients after kidney transplantation, but the mechanism is unknown. Here, we describe a patient
PMID 23123401

A [Lys^<49>]phospholipase A_2 from Protobothrops flavoviridis Venom Induces Caspase-Independent Apoptotic Cell Death Accompanied by Rapid Plasma-Membrane Rupture in Human Leukemia Cells

MURAKAMI Tatsuo,KAMIKADO Nobuyuki,FUJIMOTO Ryo,HAMAGUCHI Kazuhiko,NAKAMURA Hitomi,CHIJIWA Takahito,OHNO Motonori,ODA UEDA Naoko
Bioscience, biotechnology, and biochemistry 75(5), 864-870, 2011-05-23
… venom contains plural phospholipase A<SUB>2</SUB> … its cell-surface receptor. …
NAID 10028272404

海外論文紹介 : M-Type Phospholipase A2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy

Activation of Cytosolic Phospholipase A_2α by Epidermal Growth Factor (EGF) and Phorbol Ester in HeLa Cells : Different Effects of Inhibitors for EGF Receptor, Protein Kinase C, Src, and C-Raf

MATSUZAWA Yasuo,KIUCHI Yoshiaki,TOYOMURA Kaori,MATSUMOTO Ikiru,NAKAMURA Hiroyuki,FUJINO Hiromichi,MURAYAMA Toshihiko,KAWASHIMA Tatsuo
Journal of pharmacological sciences 111(2), 182-192, 2009-10-20
… In several types of cancer cells, prostaglandins produced via the over-expression of epidermal growth factor receptor (EGFR) and cyclooxygenases regulate cell growth. … α-type cytosolic phospholipase A<sub>2</sub> …
NAID 10025739155