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〈C〉(車などの)転覆,転倒 / 〈U〉《しばしば a…》(一定期間内の)総取り引き高,売り上げ高 / 〈U〉《しばしば s…》(一定期間内の)補充労働者の総数(割合) / 〈U〉《しばしば a…》(一定期間内の)商品の回転率 / 〈C〉〈U〉(半円形形または三角形の)折り重ねパイ

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Phosphatidylinositol 4-Phosphate 5-Kinase α and Vav1 Mutual Cooperation in CD28-Mediated Actin Remodeling and Signaling Functions.

Muscolini M1, Camperio C1, Porciello N1, Caristi S1, Capuano C2, Viola A3, Galandrini R2, Tuosto L4.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Feb 1;194(3):1323-33. doi: 10.4049/jimmunol.1401643. Epub 2014 Dec 24.
Phosphatidylinositol 4,5-biphosphate (PIP2) is a cell membrane phosphoinositide crucial for cell signaling and activation. Indeed, PIP2 is a pivotal source for second messenger generation and controlling the activity of several proteins regulating cytoskeleton reorganization. Despite its critical ro
PMID 25539813

LY294002 inhibits the malignant phenotype of osteosarcoma cells by modulating the phosphatidylinositol 3‑kinase/Akt/fatty acid synthase signaling pathway in vitro.

Zhou Y1, Zhu LB1, Peng AF2, Wang TF1, Long XH1, Gao S1, Zhou RP3, Liu ZL1.
Molecular medicine reports.Mol Med Rep.2015 Feb;11(2):1352-7. doi: 10.3892/mmr.2014.2787. Epub 2014 Oct 27.
Increasing evidence suggests that fatty acid synthase (FASN) is crucial in the carcinogenesis of various types of tumor. In addition, the phosphatidylinositol 3‑kinase (PI3K)/Akt signaling pathway, which is closely associated with cellular metabolism, affects cancer biology. However, whether the m
PMID 25351625

Transcription factor TIP27 regulates glucose homeostasis and insulin sensitivity in a PI3-kinase/Akt dependent manner in mice.

Yuan L1, Luo X2, Zeng M1, Zhang Y1, Yang M3, Zhang L1, Liu R1, Boden G4, Liu H5, Alex Ma Z6, Li L1, Yang G1.
International journal of obesity (2005).Int J Obes (Lond).2015 Jan 23. doi: 10.1038/ijo.2015.5. [Epub ahead of print]
Background/ObjectivesJuxtaposed with another zinc finger gene 1 (TIP27 or JAZF1) is a 27 kDa transcription factor, and genome-wide association studies (GWAS) have recently revealed TIP27 to be associated with type 2 diabetes. However, little is known about its role in the regulation of metabolism. I
PMID 25614086

イノシトールリン脂質代謝酵素の生理的重要性 Physiological functions of phosphatidylinositol turnover enzymes

High-Glucose Enhances a Thromboxane A_2-Induced Aortic Contraction Mediated by an Alteration of Phosphatidylinositol Turnover

NOBE Koji,SUZUKI Hikaru,NOBE Hiromi,SAKA Yasushi,MOMOSE Kazutaka
Journal of pharmacological sciences 92(3), 267-282, 2003-07-01
… Increased myo-inositol incorporation was detected under high-glucose conditions, indicating an acceleration of phosphatidylinositol (PI)-turnover. … These findings indicated that HG-PSS treatment increases DG synthesis derived from incorporated glucose, PKC and DG kinase activation, and enhances the U46619-induced contraction via acceleration of PI-turnover. …
NAID 130000073655