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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/12 20:21:15」(JST)

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1. Chapter 6F：カルシウム・リンバランスにおけるホルモン調節 chapter 6f hormonal regulation of calcium and phosphate balance
2. 心筋における興奮収縮連関 excitation contraction coupling in myocardium
3. Chapter 6A：ホルモンの作用機序 chapter 6a mechanisms of hormone action
4. 抗リン脂質抗体症候群の病因 pathogenesis of the antiphospholipid syndrome
5. T細胞受容体シグナル伝達 t cell receptor signaling

Plasma membrane aminoglycerolipid flippase function is required for signaling competence in the yeast mating pheromone response pathway.

Sartorel E1, Barrey E1, Lau RK1, Thorner J2.
Molecular biology of the cell.Mol Biol Cell.2014 Nov 5. pii: mbc.E14-07-1193. [Epub ahead of print]
Class-4 P-type ATPases ("flippases") maintain membrane asymmetry by translocating phosphatidylethanolamine and phosphatidylserine from the outer leaflet to the cytosolic leaflet of the plasma membrane. In S. cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2 and Neo1) are implicated in f
PMID 25378585

PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation.

Mackey AM1, Sarkes DA2, Bettencourt I2, Asara JM3, Rameh LE4.
Science signaling.Sci Signal.2014 Nov 4;7(350):ra104. doi: 10.1126/scisignal.2005191.
Phosphatidylinositol-5-phosphate 4-kinases (PIP4ks) are a family of lipid kinases that specifically use phosphatidylinositol 5-monophosphate (PI-5-P) as a substrate to synthesize phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. Suppression of PIP4k function in Drosophila results in smaller cells a
PMID 25372051

Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation.

Chang J, Lee S, Blackstone C.
The Journal of clinical investigation.J Clin Invest.2014 Nov 3. pii: 77598. doi: 10.1172/JCI77598. [Epub ahead of print]
Autophagy allows cells to adapt to changes in their environment by coordinating the degradation and recycling of cellular components and organelles to maintain homeostasis. Lysosomes are organelles critical for terminating autophagy via their fusion with mature autophagosomes to generate autolysosom
PMID 25365221

Alterations in Intestinal Permeability Cause Colonic Inflammation and Fibrosis in Type III Phosphatidylinositol Phosphate Kinase-Deficient Mice

NAKAMURA Ryotaro,TAKASUGA Shunsuke,HORIE Yasuo,SASAKI Takehiko
秋田医学 41(3-4), 129-135, 2015-03-31
… We recently established mice lacking the type III phosphatidylinositol phosphate kinase gene(PipkIII) in enterocytes, which represent a unique model of intestinal inflammation associatedwith extensive fibrosis that closely resembles human Crohn's disease. …
NAID 120005616171

Phosphatidylinositol 3-kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced smad signaling in endothelial cells

Aki Sho,Yoshioka Kazuaki,Okamoto Yasuo,Takuwa Noriko,Takuwa Yoh
Journal of Biological Chemistry 290(10), 6086-6105, 2015-03-06
… We have recently demonstrated that the PI3K class II-α isoform (PI3K-C2α), which generates phosphatidylinositol 3-phosphate and phosphatidylinositol 3,4-bisphosphates, plays crucial roles in angiogenesis, by analyzing PI3K-C2α knock-out mice. … The PI3K-C2α actions are mediated at least in part through its participation in the internalization of VEGF receptor-2 and sphingosine-1-phosphate receptor S1P1 and thereby their signaling on endosomes. …
NAID 120005593954

Relationship between sodium-dependent phosphate transporter (NaPi-IIc) function and cellular vacuole formation in opossum kidney cells

Shiozaki Yuji,Segawa Hiroko,Ohnishi Saori,Ohi Akiko,Ito Mikiko,Kaneko Ichiro,Kido Shinsuke,Tatsumi Sawako,Miyamoto Ken-ichi
The Journal of Medical Investigation 62(3.4), 209-218, 2015
… NaPi-IIc/SLC34A3 is a sodium-dependent inorganic phosphate (Pi) transporter in the renal proximal tubules and its mutations cause hereditary hypophosphatemic rickets with hypercalciuria (HHRH). … Immunocytochemistry revealed that endogenous and exogenous oNaPi-IIc proteins localized at the protrusion of the plasma membrane, which is a phosphatidylinositol 4,5-bisphosphate (PIP2) rich-membrane, and at the intracellular vacuolar membrane. …
NAID 130005099143