phosphatidylinositol 3-kinase

出典: meddic

PI-3 kinase

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/07/14 21:40:16」(JST)

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  • Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-κB and PI3K/Akt signaling pathways.
  • Yuan FL1, Xu RS1, Jiang DL1, He XL1, Su Q1, Jin C1, Li X1.
  • Bone.Bone.2015 Jun;75:128-37. doi: 10.1016/j.bone.2015.02.017. Epub 2015 Feb 21.
  • Osteoclasts, the primary bone resorbing cells, are responsible for destructive bone diseases such as postmenopausal osteoporosis, rheumatoid arthritis, and periodontitis. Many plant-derived traditional medicines that might suppress the formation and/or function of osteoclasts are promising treatment
  • PMID 25708053
  • Oleuropein induces apoptosis via activation of caspases and suppression of phosphatidylinositol 3-kinase/protein kinase B pathway in HepG2 human hepatoma cell line.
  • Yan CM1, Chai EQ2, Cai HY1, Miao GY1, Ma W1.
  • Molecular medicine reports.Mol Med Rep.2015 Jun;11(6):4617-24. doi: 10.3892/mmr.2015.3266. Epub 2015 Jan 28.
  • Oleuropein is a polyphenol, that is found in extra‑virgin olive oil. Previous studies have shown that oleuropein inhibits cell proliferation and induces apoptosis in breast cancer, colorectal cancer and thyroid cancer. The aim of the present study was to investigate the effects of oleuropein in he
  • PMID 25634350
  • Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis.
  • Ikonomov OC1, Sbrissa D1, Venkatareddy M2, Tisdale E3, Garg P2, Shisheva A4.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2015 May;1853(5):1240-50. doi: 10.1016/j.bbamcr.2015.01.008. Epub 2015 Jan 22.
  • The evolutionarily conserved PIKfyve, which synthesizes PtdIns5P from PtdIns, and PtdIns(3,5)P2 from PtdIns3P, requires PtdIns3P as both an enzyme substrate and a membrane recruitment signal. Whereas the PtdIns3P source is undetermined, class III PI3K (Vps34), the only evolutionarily conserved of th
  • PMID 25619930


  • Anandamide enhances expression of heat shock protein 72 to protect against ischemia?reperfusion injury in rat heart
  • Li Qian,Shi Min,Li Bo
  • The journal of physiological sciences 63(1), 47-53, 2013-01
  • NAID 40019538830
  • Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function
  • Yoshioka Kazuaki,Yoshida Kotaro,Cui Hong,Wakayama Tomohiko,Takuwa Noriko,Okamoto Yasuo,Du Wa,Qi Xun,Asanuma Ken,Sugihara Kazushi,Aki Sho,Miyazawa Hidekazu,Biswas Kuntal,Nagakura Chisa,Ueno Masaya,Iseki Shoichi,Schwartz Robert J.,Okamoto Hiroshi,Sasaki Takehiko,Matsui Osamu,Asano Masahide,Adams Ralf H.,Takakura Nobuyuki,Takuwa Yoh
  • Nature Medicine 18(10), 1560-1569, 2012-10
  • … The class II α-isoform of phosphatidylinositol 3-kinase (PI3K-C2α) is localized in endosomes, the trans-Golgi network and clathrin-coated vesicles; … Global or endothelial-cell-specific deficiency of PI3K-C2α resulted in embryonic lethality caused by defects in sprouting angiogenesis and vascular maturation. …
  • NAID 120004966617
  • Sphingosine-1-phosphate signaling in physiology and diseases
  • Takuwa Yoh,Okamoto Yasuo,Yoshioka Kazuaki,Takuwa Noriko
  • BioFactors 38(5), 329-337, 2012-09
  • … In addition, S1P 1 mediates stimulation of cell proliferation through the G i-mediated signaling pathways including phosphatidylinositol 3-kinase (PI3K)/Akt and ERK whereas S1P 2 mediates inhibition of cell proliferation through mechanisms involving G 12/13/Rho/Rho kinase/PTEN-dependent Akt inhibition. …
  • NAID 120004966620


The phosphatidylinositol 3-kinases (PI3Ks) are grouped into three classes (I – III) which differ in structure and function (Fruman et al. 1998; Vanhaesebroeck et al. 1997; Vanhaesebroeck and Waterfield 1999). Class I enzymes have ...
The pathogenesis of essential hypertension is multifactorial. Although the cause of elevated arterial pressure is unknown in most cases, the fundamental hemodynamic abnormality in hypertension is increased peripheral ...


 of Phosphatidylinositol 3-Kinase (PI3Kphosphatidylinositol 3-kinase-Akt Phosphatidylinositol-3-kinase-PI3K-Akt The phosphatidylinositol 3-Kinase|[ndash The phosphatidylinositol 3-Kinase|[ndash  キナーゼ - Phosphoinositide 3-kinase

リンク元PI3-kinase」「PI 3-kinase」「イノシトールリン脂質3キナーゼ」「PI-3K」「ホスファチジルイノシトール-3-キナーゼ
拡張検索1-phosphatidylinositol 3-kinase




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PI 3-kinase」



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1-phosphatidylinositol 3-kinasephosphatidylinositol 3-kinasephosphoinositide 3-kinasePI 3-kinasePI-3 kinasePI3-kinasePI3KPtdIns 3-kinase



phosphatidylinositol 3-kinasePtdIns 3-kinase

1-phosphatidylinositol 3-kinase」



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  [★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase

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「an enzyme that catalyzes the conversion of a proenzyme to an active enzyme」



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「the basic unit of money in Papua New Guinea」


  [★] ホスファチジルイノシトール