philadelphia chromosome

出典: meddic



  • Clinical overview of anti-CD19 BiTE(®) and ex vivo data from anti-CD33 BiTE(®) as examples for retargeting T cells in hematologic malignancies.
  • Zugmaier G1, Klinger M2, Schmidt M1, Subklewe M3.
  • Molecular immunology.Mol Immunol.2015 Oct;67(2 Pt A):58-66. doi: 10.1016/j.molimm.2015.02.033. Epub 2015 Apr 13.
  • Blinatumomab, a bispecific antibody construct targeting CD19, is the most advanced member of bispecific T-cell engager (BiTE(®)) molecules. The clinical development program includes B-precursor acute lymphoblastic leukemia (ALL) and B-cell non-Hodgkin lymphoma (NHL). Minimal residual disease (MRD)
  • PMID 25883042
  • The e1a3 BCR-ABL1 Fusion Transcript in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.
  • Langabeer SE1.
  • Annals of laboratory medicine.Ann Lab Med.2015 Sep;35(5):540-1. doi: 10.3343/alm.2015.35.5.540.
  • PMID 26206693
  • Prognostification of ALL by Cytogenetics.
  • Hakeem A1, Shiekh AA1, Bhat GM1, Lone AR1.
  • Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion.Indian J Hematol Blood Transfus.2015 Sep;31(3):322-31. doi: 10.1007/s12288-014-0483-0. Epub 2014 Dec 11.
  • Cytogenetic abnormalities in chromosomal number and structure are common in pediatric ALL and some have prognostic significance. One interesting association between cytogenetic status and treatment response involves the metabolism of methotrexate. Hyperdiploid lymphoblasts accumulate increased amoun
  • PMID 26085716


  • 当科での急性リンパ性白血病の治療成績
  • 志村 華絵,森 直樹,岡田 美智子,榎本 有希,渡邉 彩,石森 紀子,丁 曄,兒玉 聖子,田中 紀奈,三橋 健次郎,石山 みどり,風間 啓至,吉永 健太郎,今井 陽一,志関 雅幸,寺村 正尚,泉二 登志子
  • 東京女子医科大学雑誌 83(E2), E556-E562, 2013-03-31
  • 2002年10月から2012年10月までの10年間に当科で診断、治療した成人急性リンパ性白血病 (Acute lymphoblastic leukemia : ALL) 35例 (B-ALL 27例、T-ALL 8例) を対象とし、臨床経過と治療成績を後方視的に解析した.追跡期間中央値は930日、年齢中央値は43歳 (16歳-90歳) で、男性16人 (45.7%)、女性19人 (54.3%) で …
  • NAID 110009575065
  • Identification of novel genomic regions with aberrant cytosine methylation in hematological malignancies
  • Kobayashi Yujin,Fujiwara Kyoko,Hatta Yoshihiro,Takeuchi Jin,Shinojima Yui,Kawashima Hiroyuki,Igarashi Jun,Soma Masayoshi,Nagase Hiroki
  • Annals of Cancer Research and Therapy 21(1), 01-13, 2013
  • … Aberrant hypermethylation of ZAR1, GATA4 and CDH22 was also frequently observed in both Philadelphia chromosome positive and negative ALL samples but not in all 10 AML cases. …
  • NAID 130003366756
  • Synthesis and Biopharmaceutical Studies of JLTN as Potential Dasatinib Prodrug
  • Liu Fei,Lang LiWei,Jiang Ji,Lu HuaJun,Wang JianMin,Wang Shih-Chen
  • Chemical and Pharmaceutical Bulletin, 2013
  • … Dasatinib was identified as a potent orally administered Src/Abl kinase inhibitor with excellent antiproliferative activity against Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia in chronic phase. …
  • NAID 130003360822


An explanation of the Philadelphia chromosome including where it comes from, how it effects the bone marrow, and disease that it is commonly seen in. ... As part of their assessment, doctors will look for the presence ...
内容紹介. Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of k



関連記事Philadelphia」「chromosome」「Philadelphia chromosome





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「the largest city in Pennsylvania; located in the southeastern part of the state on the Delaware river; site of Independence Hall where the Declaration of Independence and the Constitution were signed; site of the University of Pennsylvania」
City of Brotherly Love

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「a threadlike strand of DNA in the cell nucleus that carries the genes in a linear order; "humans have 22 chromosome pairs plus two sex chromosomes"」

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Philadelphia chromosome」

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