フェロモン受容体、フェロモンレセプター

WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
a chemical substance secreted externally by some animals (especially insects) that influences the physiology or behavior of other animals of the same species

PrepTutorEJDIC

=sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/06/13 06:57:54」(JST)

wiki en

Pheromones have evolved in all animal phyla, to signal sex and dominance status, and are responsible for stereotypical social and sexual behaviour among members of the same species. In mammals, these chemical signals are believed to be detected primarily by the vomeronasal organ (VNO), a chemosensory organ located at the base of the nasal septum^[1].

The VNO is present in most amphibia, reptiles and non-primate mammals but is absent in birds, adult catarrhine monkeys and apes^[2]. An active role for the human VNO in the detection of pheromones is disputed; the VNO is clearly present in the fetus but appears to be atrophied or absent in adults. Three distinct families of putative pheromone receptors have been identified in the vomeronasal organ (V1Rs, V2Rs and V3Rs). All are G protein-coupled receptors but are only distantly related to the receptors of the main olfactory system, highlighting their different role^[1].

The V1 receptors share between 50 and 90% sequence identity but have little similarity to other families of G protein-coupled receptors. They appear to be distantly related to the mammalian T2R bitter taste receptors and the rhodopsin-like GPCRs^[3]. In rat, the family comprises 30-40 genes. These are expressed in the apical regions of the VNO, in neurons expressing Gi2. Coupling of the receptors to this protein mediates inositol trisphosphate signalling^[1]. A number of human V1 receptor homologues have also been found. The majority of these human sequences are pseudogenes^[4] but an apparently functional receptor has been identified that is expressed in the human olfactory system^[5].

Human proteins containing this domain

VN1R1; VN1R2; VN1R3; VN1R5;

References

^ ^a ^b ^c Pantages E, Dulac C (2000). "A novel family of candidate pheromone receptors in mammals". Neuron 28 (3): 835–845. DOI:10.1016/S0896-6273(00)00157-4. PMID 11163270.
^ Keverne EB (1999). "The vomeronasal organ". Science 286 (5440): 716–720. DOI:10.1126/science.286.5440.716. PMID 10531049.
^ Josefsson LG (1999). "Evidence for kinship between diverse G-protein coupled receptors". Gene 239 (2): 333–340. DOI:10.1016/S0378-1119(99)00392-3. PMID 10548735.
^ Trask BJ, Giorgi D, Friedman C, Rouquier S (2000). "Characterization of nonfunctional V1R-like pheromone receptor sequences in human". Genome Res. 10 (12): 1979–1985. DOI:10.1101/gr.10.12.1979. PMC 313059. PMID 11116092. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=313059.
^ Rodriguez I, Greer CA, Mok MY, Mombaerts P (2000). "A putative pheromone receptor gene expressed in human olfactory mucosa". Nat. Genet. 26 (1): 18–19. DOI:10.1038/79124. PMID 10973240.

This article incorporates text from the public domain Pfam and InterPro IPR004072

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. インスリン受容体の構造および機能 structure and function of the insulin receptor
2. 免疫不全症を引き起こすCD3／T細胞受容体複合体疾患 cd3 t cell receptor complex disorders causing immunodeficiency
3. T細胞受容体の遺伝学 t cell receptor genetics
4. T細胞受容体シグナル伝達 t cell receptor signaling
5. 乳癌予防のための選択的エストロゲン受容体調節因子およびアロマターゼ阻害剤 selective estrogen receptor modulators and aromatase inhibitors for breast cancer prevention

English Journal

Identification of Functionally Important Residues of the Silkmoth Pheromone Biosynthesis-Activating Neuropeptide Receptor, an Insect Ortholog of the Vertebrate Neuromedin U Receptor.

Kawai T1, Katayama Y1, Guo L1, Liu D1, Suzuki T1, Hayakawa K1, Lee JM2, Nagamine T2, Hull JJ3, Matsumoto S2, Nagasawa H1, Tanokura M4, Nagata K1.
The Journal of biological chemistry.J Biol Chem.2014 May 20. pii: jbc.M113.488999. [Epub ahead of print]
The biosynthesis of sex pheromone components in many lepidopteran insects is regulated by the interaction between pheromone biosynthesis-activating neuropeptide (PBAN) and the PBAN receptor (PBANR), a class-A G-protein-coupled receptor (GPCR). To identify functionally important amino acid residues i
PMID 24847080

ORA1, a zebrafish olfactory receptor ancestral to all mammalian V1R genes, recognizes 4-hydroxyphenylacetic acid, a putative reproductive pheromone.

Behrens M1, Frank O2, Rawel H3, Ahuja G4, Potting C4, Hofmann T2, Meyerhof W1, Korsching S5.
The Journal of biological chemistry.J Biol Chem.2014 May 15. pii: jbc.M114.573162. [Epub ahead of print]
The teleost v1r-related ora genes are a small, highly conserved olfactory receptor gene family of only six genes, whose direct orthologues can be identified in lineages as far as that of cartilaginous fish. However, no ligands for fish ORAs had been uncovered so far. Here we have deorphanized the OR
PMID 24831010

Facile functional analysis of insect odorant receptors expressed in the fruit fly: validation with receptors from taxonomically distant and closely related species.

Ueira-Vieira C1, Kimbrell DA, de Carvalho WJ, Leal WS.
Cellular and molecular life sciences : CMLS.Cell Mol Life Sci.2014 May 13. [Epub ahead of print]
With the advent of genomic sequences and next-generation sequencing technologies (RNA-Seq), multiple repertoires of olfactory proteins in various insect species are being unraveled. However, functional analyses are lagging behind due in part to the lack of simple and reliable methods for heterologou
PMID 24816944

Japanese Journal

エコロジカル・ボラタイル : 生態系での香りの機能(第8回)哺乳類の行動を制御するエコロジカルボラタイルとその受容体の同定法

吉川敬一,東原和成
Aroma research = アロマリサーチ : journal of aroma science technology and safety 14(2), 180-184, 2013
NAID 40019741731

Naloxone Blocks the Deterioration of Male Sexual Behavior Induced by Alarm Pheromone in Rats

KOBAYASHI Tatsuya,KIYOKAWA Yasushi,ARATA Sayaka [他],TAKEUCHI Yukari,MORI Yuji
Journal of Veterinary Medical Science 75(6), 761-765, 2013
… Previously, we have demonstrated that the alarm pheromone deteriorates sexual behavior in male rats, which was blocked by pretreatment with a corticotrophin-releasing hormone (CRH) antagonist. … Therefore, possibly, the pheromone effects could also be mediated by the opioid system. … In this study, we pretreated rats with naloxone, an opioid receptor antagonist, and examined the following sexual behavior modulations in male rats that were exposed to the alarm pheromone. …
NAID 130003362126

Electrophysiological and Morphological Evidence for Synchronized GnRH Pulse Generator Activity Among Kisspeptin/Neurokinin B/Dynorphin A (KNDy) Neurons in Goats

WAKABAYASHI Yoshihiro,YAMAMURA Takashi,SAKAMOTO Kohei [他],MORI Yuji,OKAMURA Hiroaki
Journal of Reproduction and Development 59(1), 40-48, 2013
… Spontaneous and pheromone- or senktide (an NKB receptor agonist)-induced MUA volleys were simultaneously recorded from both sides of the ARC. …
NAID 130001854903