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a way of doing something, especially a systematic way; implies an orderly logical arrangement (usually in steps)

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1. 乳幼児および思春期前の小児における通常の成長パターン normal growth patterns in infants and prepubertal children
2. 在胎月齢の生後評価 postnatal assessment of gestational age
3. Fertility awareness法での避妊 fertility awareness based methods of pregnancy prevention
4. 低身長の小児および思春期患者に対する診断的アプローチ diagnostic approach to children and adolescents with short stature
5. 腰痛の運動療法 exercise based therapy for low back pain

Isolation and Characterization of Acetylated Derivative of Recombinant Insulin Lispro Produced in Escherichia coli.

Szewczak J1, Bierczyńska-Krzysik A, Piejko M, Mak P, Stadnik D.
Pharmaceutical research.Pharm Res.2015 Jul;32(7):2450-7. doi: 10.1007/s11095-015-1637-y. Epub 2015 Feb 7.
PURPOSE: Insulin lispro is a rapid-acting insulin analogue produced by recombinant DNA technology. As a biosynthetic drug, the protein undergoes strict monitoring aiming for detection and characterization of impurities. The goal of this study was to isolate and identify a derivative of insulin lispr
PMID 25663326

Safety of enzalutamide in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel: expanded access in North America.

Joshua AM1, Shore ND, Saad F, Chi KN, Olsson CA, Emmenegger U, Scholz M, Berry W, Mukherjee SD, Winquist E, Haas NB, Foley MA, Dmuchowski C, Perabo F, Hirmand M, Hasabou N, Rathkopf D; Enzalutamide Expanded Access Study Investigators.
The Prostate.Prostate.2015 Jun;75(8):836-44. doi: 10.1002/pros.22965. Epub 2015 Feb 14.
BACKGROUND: The open-label, single-arm enzalutamide expanded access program (EAP) in the United States and Canada evaluated the safety of enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) who had previously received docetaxel.METHODS: Patients (n = 507) receiv
PMID 25683285

Effect of enzalutamide on health-related quality of life, pain, and skeletal-related events in asymptomatic and minimally symptomatic, chemotherapy-naive patients with metastatic castration-resistant prostate cancer (PREVAIL): results from a randomised, phase 3 trial.

Loriot Y1, Miller K2, Sternberg CN3, Fizazi K4, De Bono JS5, Chowdhury S6, Higano CS7, Noonberg S8, Holmstrom S9, Mansbach H10, Perabo FG11, Phung D11, Ivanescu C12, Skaltsa K13, Beer TM14, Tombal B15.
The Lancet. Oncology.Lancet Oncol.2015 May;16(5):509-21. doi: 10.1016/S1470-2045(15)70113-0. Epub 2015 Apr 14.
BACKGROUND: Enzalutamide significantly increased overall survival and radiographic progression-free survival compared with placebo in the PREVAIL trial of asymptomatic and minimally symptomatic, chemotherapy-naive patients with metastatic castration-resistant prostate cancer. We report the effect of
PMID 25888263

On-line sample concentration capillary electrophoresis for the analysis of metabolic intermediates in the cell.

寺部茂,Quirino Joselito P.,Markuszewski Michal J.,井上直子,佐伯知香,大塚浩二,西岡孝明
生物物理化学 45(2), 117-121, 2001
… A mixture of 22 phenylthiohydantoin (PTH) amino acids and that of 6 aromatic carboxylic acids were employed as standard samples to evaluate the CE method from a viewpoint of detection sensitivity. …
NAID 130003607249

ATTOMOLE DETERMINATION OF PHENYL THIOHYDANTOIN DERIVATIVES OF AMINO ACIDS BY CAPILLARY ZONE ELECTROPHORESIS SEPARATION AND ULTRAVIOLET-LASER EXCITED THERMO-OPTICAL ABSORBANCE DETECTION

Waldron Karen C.,Miller Jean,Dovichi Norman J.
Analytical Sciences 7(Supple), 959-961, 1991
… Capillary zone electrophoresis provides a rapid method for the analysis of minute amounts of amino acids. … A laser-based absorbance technique is used to determine phenylthiohydantoin amino acids with detection limits of 10-15 mol; …
NAID 130003529702

Selective separation of tryptophan-containing peptides via hydrophobic modification with 2-nitro-4-carboxyphenylsulfenyl chloride.

TANAKA Shuji,MOHRI Noriko,KIHARA Hiroshi,OHNO Motonori
The Journal of Biochemistry 97(5), 1377-1384, 1985
… The tryptophan-containing peptides from the tryptic digests of S-carboxymethylated hen-egg white lysozyme and Trimeresurus flavoviridis phospholipase A2 were thus selectively separated and the amino acid sequences were determined, showing the validity of the method. … The phenylthiohydantoin derivative of 2-(2'-nitro-4'-carboxyphenyl-thio)-L-tryptophan was synthesized and its spectroscopic and chromatographic properties determined, enabling us to identify the derivative on Edman sequencing. …
NAID 130003543303