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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/23 01:14:44」(JST)
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Phenprobamate
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| Systematic (IUPAC) name |
| 3-Phenylpropylcarbamate |
| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
| Legal status |
? |
| Pharmacokinetic data |
| Half-life |
5 - 8 hours |
| Identifiers |
| CAS number |
673-31-4 N |
| ATC code |
M03BA01 |
| PubChem |
CID 4770 |
| ChemSpider |
4606 Y |
| UNII |
UJZ473TPS0 Y |
| KEGG |
D01824 Y |
| ChEMBL |
CHEMBL1079576 Y |
| Chemical data |
| Formula |
C10H13NO2 |
| Mol. mass |
179.22 |
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InChI
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InChI=1S/C10H13NO2/c11-10(12)13-8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H2,11,12) Y
Key:CAMYKONBWHRPDD-UHFFFAOYSA-N Y
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| N (what is this?) (verify) |
Phenprobamate (Gamaquil, Isotonil) is a centrally acting skeletal muscle relaxant, with additional sedative and anticonvulsant effects. Overdose is similar to barbiturates. Its mechanism of action is probably similar to meprobamate. Phenprobamate was previously used in humans as an anxiolytic, and is still sometimes used in general anesthesia and for treating muscle cramps and spasticity. Phenprobamate is still used in some European countries, but it has generally been replaced by newer drugs. Phenprobamate is metabolized by oxidative degradation of the carbamate group and ortho-hydroxylation of the benzene ring, and is eliminated in urine by the kidneys.
Doses range from 400 to 800 mg, up to 3 times a day.
References[edit]
- The Comparative Toxicogenomics Database: Phenprobamate
- Chembank: Phenprobamate
- Nephrology Dialysis Transplantation Volume 17, Number 5, Pp. 941. Letters: Haemoperfusion may be useful in phenprobamate and polypharmacy intoxication of paediatric patients.
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Skeletal muscle relaxants (M03)
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Peripherally acting
(primarily antinicotinic,
NMJ block) |
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Non-depolarizing
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Curare alkaloids
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- Alcuronium
- Dimethyltubocurarine
- Tubocurarine
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4° ammonium agents
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- ultra-short duration: Gantacurium
- short duration: Mivacurium
- Chandonium
- intermediate duration: Atracurium
- Cisatracurium
- Fazadinium
- Rocuronium
- Vecuronium
- long duration: Doxacurium
- Dimethyltubocurarine
- Pancuronium
- Pipecuronium
- Laudexium
- Gallamine
- unsorted: Hexafluronium (Hexafluorenium)
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Depolarizing
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- Choline derivatives: Suxamethonium (Succinylcholine)
- Polyalkylene derivatives: Hexamethonium
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ACh release inhibitors
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| Centrally acting |
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Carbamic acid esters
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- Carisoprodol
- Cyclarbamate
- Difebarbamate
- Febarbamate
- Meprobamate
- Methocarbamol
- Phenprobamate
- Styramate
- Tybamate
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Benzodiazepines
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- Bentazepam
- Bromazepam
- Diazepam
- Clonazepam
- Flunitrazepam
- Lorazepam
- Nitrazepam
- Tetrazepam
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Nonbenzodiazepines
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Thienodiazepines
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Quinazolines
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Anticholinergics (Antimuscarinics)
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- Cyclobenzaprine
- Orphenadrine
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Other
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- Arbaclofen placarbil
- Baclofen
- Chlormezanone
- Chlorphenesin
- Chlorzoxazone
- Donepezil
- Eperisone
- Fenyramidol
- Flopropione
- GHB
- Mephenesin
- Mephenoxalone
- Metaxalone
- Phenibut
- Pridinol
- Promoxolane
- Quinine
- Thiocolchicoside
- Tizanidine
- Tolperisone
- Trazodone
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| Directly acting |
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anat (h/n, u, t/d, a/p, l)/phys/devp/hist
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noco (m, s, c)/cong (d)/tumr, sysi/epon, injr
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English Journal
- Plasmapheresis is useful in phenprobamate overdose.
- Emet M, Aslan S, Cakir ZG, Uyanik A, Uzkeser M, Hacimuftuoglu A, Emre H.SourceDepartment of Emergency Medicine, Ataturk University, Erzurum 25200, Turkey. mucahitemet@gmail.com
- The American journal of emergency medicine.Am J Emerg Med.2009 Jun;27(5):626.e1-2. doi: 10.1016/j.ajem.2008.08.022.
- Although previous scientific articles claim that morbidity and mortality are low in pure skeletal muscle relaxant ingestion, this is the 10th leading cause of death recently; however, this represents only a 2.1% ratio in adult toxic exposures in the United States. We report the case of a patient wit
- PMID 19497474
- Haemoperfusion may be useful in phenprobamate and polypharmacy intoxication of paediatric patients.
- Tasdemir HA, Yildiran A, Islek I, Sancak R, Dilber C.
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.Nephrol Dial Transplant.2002 May;17(5):941.
- PMID 11981094
- The rapid quantitative analysis of phenprobamate and acetaminophen by RP-LC and compensation technique.
- Altun ML, Erk N.SourceDepartment of Pharmacognosy, Faculty of Pharmacy, University of Ankara, 06100 Ankara, Turkey.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2001 Apr;25(1):85-92.
- For the analysis of phenprobamate and acetaminophen in combination, the main analytical methods used were spectrophotometric compensation technique and Vierordt's method with high performance liquid chromatography, used as an analytical reference method. The first procedure for the simultaneous quan
- PMID 11274861
Japanese Journal
- Effects of Some Antiparkinsonism Drugs and centrally Acting Muscle Relaxants on the Intercollicular Decerebrate Rigidity in Rats
- 福田 英臣,伊藤 継孝,小久保 実
- Chemical & pharmaceutical bulletin 22(12), 2883-2888, 1974-12-25
- … Mephenesin, methocarbamol, tolperisone, phenprobamate and diazepam were all effective in reducing the rigidity. …
- NAID 110003633116
- Effects of some antiparkinsonism drugs and centrally acting muscle relaxants on the intercollicular decerebrate rigidity in rats.
- 福田 英臣,伊藤 継孝,小久保 実
- Chemical and Pharmaceutical Bulletin 22(12), 2883-2888, 1974
- … Mephenesin, methocarbamol, tolperisone, phenprobamate and diazepam were all effective in reducing the rigidity. …
- NAID 130003938887
Related Links
- Phenprobamateとは？goo Wikipedia (ウィキペディア) 。出典：Wikipedia（ウィキペディア）フリー百科事典。 Phenprobamateとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ メニューへ ...
- phenprobamate phen·pro·ba·mate (fěn-prō'bə-māt') n. A skeletal muscle relaxant that also has antianxiety action. Also called proformiphen.
Related Pictures
