phenindione

フェニンジオン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/07 09:10:02」(JST)

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Phenindione

Systematic (IUPAC) name
2-phenyl-1H-indene-1,3(2H)-dione
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy category	AU: D Passes into breast milk
Routes of administration	Oral
Pharmacokinetic data
Protein binding	88%
Biological half-life	5 to 10 hours
Identifiers
CAS Number	83-12-5 Y
ATC code	B01AA02
PubChem	CID: 4760
IUPHAR/BPS	6838
DrugBank	DB00498 Y
ChemSpider	4596 Y
UNII	5M7Y6274ZE Y
KEGG	D08354 Y
ChEBI	CHEBI:8066 Y
ChEMBL	CHEMBL711 Y
Chemical data
Formula	C15H10O2
Molecular mass	222.239 g/mol
SMILES O=C2c1ccccc1C(=O)C2c3ccccc3
InChI InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H Y Key:NFBAXHOPROOJAW-UHFFFAOYSA-N Y
Y (what is this?)  (verify)

Phenindione is an anticoagulant which functions as a Vitamin K antagonist.

Hypersensitivity has been observed.

References

External links

• DDB 30536

English Journal

• Determination of rodenticides and related metabolites in rabbit liver and biological matrices by liquid chromatography coupled to Orbitrap high resolution mass spectrometry.

• López-García M1, Romero-González R1, Frenich AG2.
• Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2017 Apr 15;137:235-242. doi: 10.1016/j.jpba.2017.01.043. Epub 2017 Jan 28.
• PMID 28160742

• [Skin necrosis with vitamin K antagonists: An imbalance between coagulant and anticoagulant factors].

• Vildy S1, Osmaeva K2, Closs-Prophette F2, Maillard H3.
• La Revue de medecine interne.Rev Med Interne.2017 Feb;38(2):143-146. doi: 10.1016/j.revmed.2016.04.002. Epub 2016 Jun 1.
• PMID 27263119

• Role of ABC transporters in trans-epithelial transport of vitamin K antagonists.

• Espana B1, Couturier S2, Prouillac C1.
• Biopharmaceutics & drug disposition.Biopharm Drug Dispos.2017 Jan;38(1):20-32. doi: 10.1002/bdd.2055.
• PMID 27925230

Japanese Journal

• 血栓予防に関する研究(続報) : 新型抗血栓物質Y_<46>と抗凝固剤Phenindioneの血栓予防作用の比較 : 日本循環器学会第31回関東甲信越地方会総会

• 島本 多喜雄,藤田 地,倉井 亮,石岡 忠夫,竹内 邦夫
• Japanese circulation journal 28(8), 655, 1964-08-20
• NAID 110002588565

• Prevention of venous thrombosis and pulmonary embolism in injured patients : A trial of anticoagulant prophylaxis with phenindione in middle-aged and elderly patients with fractured necks of femur

• SEVITT S
• Lancet 2, 981-989, 1959
• NAID 30006060722

Related Links

• Phenindione - an anticoagulant. Side effects and dosage | Patient

Phenindione is an anticoagulant. It will be prescribed if you have an unwanted clot in your blood, or if you are at risk of having an unwanted clot. You will be given a yellow booklet about your anticoagulant treatment; read this carefully.

• DrugBank: Phenindione

Identification Name Phenindione Accession Number DB00498 (APRD00166) Type Small Molecule Groups Approved Description An indandione that has been used as an anticoagulant. Phenindione has actions similar to warfarin, but ...