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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/02/07 01:48:21」(JST)
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Pheneturide
|
Systematic (IUPAC) name |
(RS)-N-carbamoyl-2-phenyl-butanamide |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Pregnancy cat. |
? |
Legal status |
? |
Identifiers |
CAS number |
90-49-3 N |
ATC code |
N03AX13 |
PubChem |
CID 72060 |
ChemSpider |
65046 Y |
UNII |
878CEJ4HGX N |
KEGG |
D01190 Y |
Chemical data |
Formula |
C11H14N2O2 |
Mol. mass |
206.241 g/mol |
SMILES
- O=C(N)NC(=O)C(c1ccccc1)CC
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InChI
-
InChI=1S/C11H14N2O2/c1-2-9(10(14)13-11(12)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H3,12,13,14,15) Y
Key:AJOQSQHYDOFIOX-UHFFFAOYSA-N Y
|
N (what is this?)
|
Pheneturide (or ethylphenacemide) is an anticonvulsant medication.[1]
References
- ^ Byrne B, Rothchild R (1999). "1H NMR studies of drugs with achiral and chiral lanthanide shift reagents: applications to the anticonvulsant pheneturide". Chirality 11 (7): 529–35. doi:10.1002/(SICI)1520-636X(1999)11:7<529::AID-CHIR3>3.0.CO;2-K. PMID 10423278.
Anticonvulsants (N03)
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GABAA receptor agonist |
Barbiturates
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- Barbexaclone
- Metharbital
- Methylphenobarbital
- Pentobarbital
- Phenobarbital#
- Primidone
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Benzodiazepines
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- Clobazam
- Clonazepam
- Clorazepate
- Diazepam#
- Flutoprazepam
- Lorazepam
- Midazolam
- Nimetazepam
- Nitrazepam
- Temazepam
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Other GABA agents |
Aromatic allylic alcohols
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|
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Carbonic anhydrase inhibitor |
Sulfa drugs
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- Acetazolamide
- Ethoxzolamide
- Sultiame
- Topiramate
- Zonisamide
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Channel blockers |
Primarily sodium
|
Hydantoins
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- Ethotoin
- Fosphenytoin
- Mephenytoin
- Phenytoin#
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Carboxamides
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- Carbamazepine#
- Eslicarbazepine acetate
- Oxcarbazepine
- Oxitriptyline
- Rufinamide
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Primarily calcium
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Succinimides
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- Ethosuximide#
- Mesuximide
- Phensuximide
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AMPA receptor
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Unknown/ungrouped
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- Phenyltriazine (Lamotrigine), Oxazolidinediones (Ethadione
- Paramethadione
- Trimethadione), Ureas (Phenacemide
- Pheneturide), Monosaccharide (Topiramate)
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Channel openers |
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Indirect GABA agents |
Carboxylic acids/
Fatty acid derivatives
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- GABA transaminase inhibitor: Valproic acid# (Sodium valproate & Valproate semisodium)
- Valpromide
- Valnoctamide
- Valproate pivoxil
GABA reuptake inhibitor: Tiagabine
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|
GABA analogs
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- Gabapentin
- Pregabalin
- Progabide
- Tolgabide
- Vigabatrin
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Unknown/multiple/
unsorted |
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Carbamates
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- Emylcamate
- Felbamate
- Meprobamate
- Carisbamate
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|
Pyrrolidines
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- Brivaracetam
- Levetiracetam
- Nefiracetam
- Seletracetam
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Propionates
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Aldehydes
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Bromides
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- Potassium bromide
- Sodium bromide
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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anat (n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp
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noco (m/d/e/h/v/s)/cong/tumr, sysi/epon, injr
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proc, drug (N1A/2AB/C/3/4/7A/B/C/D)
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English Journal
- Therapeutic drug monitoring of old and newer anti-epileptic drugs.
- Neels HM1, Sierens AC, Naelaerts K, Scharpé SL, Hatfield GM, Lambert WE.
- Clinical chemistry and laboratory medicine : CCLM / FESCC.Clin Chem Lab Med.2004;42(11):1228-55.
- The aim of the present paper is to provide information concerning the setting up and interpretation of therapeutic drug monitoring (TDM) for anti-epileptic drugs. The potential value of TDM for these drugs (including carbamazepine, clobazam, clonazepam, ethosuximide, felbamate, gabapentin, lamotrigi
- PMID 15576287
- 1H NMR studies of drugs with achiral and chiral lanthanide shift reagents: applications to the anticonvulsant pheneturide.
- Byrne B1, Rothchild R.
- Chirality.Chirality.1999;11(7):529-35.
- The anticonvulsant pheneturide, PNT, has been studied by 300 MHz 1H NMR in CDCl3 at ambient temperatures with the achiral lanthanide shift reagent (LSR) Eu(FOD)3, and with the chiral LSR, Eu(HFC)3. Both LSRs produced spectral simplification of the aryl proton signal region, and substantial lanthanid
- PMID 10423278
- [Anticonvulsants and their psychological effects--a review].
- Blank R.
- Fortschritte der Neurologie-Psychiatrie.Fortschr Neurol Psychiatr.1990 Jan;58(1):19-32.
- In a review of more than 200 studies over the last three decades, the manifold psychic effects of anticonvulsives on healthy persons, on patients with and without epilepsy, on patients with mental disorders with or without cerebral damages are analysed and summarized. The following results are mainl
- PMID 2407625
Japanese Journal
- IIB-7 Pheneturide製造中止のてんかん治療に対する影響
- DIFFERENTIAL ANTAGONISMS OF ANTICONVULSANTS TO VARIOUS COMPONENTS OF MAXIMAL SEIZURES INDUCED BY ELECTROSHOCK OR PENTYLENETETRAZOL IN MICE
- MASUDA YOSHINOBU,SHIRAISHI YUKO,KARASAWA TADAHIKO,YOSHIDA KOUICHI,SHIMIZU MASANAO
- Journal of pharmacobio-dynamics 3(10), 526-531, 1980-10
- … drugs (trimethadione, ethosuximide, nitrazepam, diazepam, ethotoin and metharbital) with an effect to antagonize all the whole seizure components (TF, TH and CL or MCL) in an almost same antagonism, 2) drugs (phenacemide, dipropylacetate, pheneturide, acetylpheneturide and phenobarbital) which inhibit all forms of seizures at relatively dissociated doses for the prevention of each component of seizures, 3) drugs (diphenylhydantoin and carbamazepine) which selectively abolish both components (TF and TH) of tonic seizures, and 4) drugs (acetazolamide, …
- NAID 110003635788
- 精神運動発作に対する"Tegretol"と"Pheneturide"の薬効比較
Related Links
- ↑Byrne B, Rothchild R (1999). "1H NMR studies of drugs with achiral and chiral lanthanide shift reagents: applications to the anticonvulsant pheneturide". Chirality 11 (7): 529–35. doi:<529::AID-CHIR3>3.0.CO;2-K 10.1002/(SICI)1520 ...
- Pheneturide is a medicine available in a number of countries worldwide. A list of US medications equivalent to Pheneturide is available on the Drugs.com website. ... Drugs.com provides accurate and independent information on more ...
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