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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/23 08:00:13」(JST)

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Phenacemide (INN, BAN) (brand name Phenurone), also known as phenylacetylurea, is an anticonvulsant of the ureide (acetylurea) class.^[1] It is a congener and ring-opened analogue of phenytoin (a hydantoin),^[2]^[3] and is structurally related to the barbiturates and to other hydantoins.^[4] Phenacemide was introduced in 1949 for the treatment of epilepsy, but was eventually withdrawn due to toxicity.^[2]^[3]

ReferencesEdit

^ C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1578–. ISBN 978-0-412-46630-4.
^ ^a ^b Conceptual Pharmacology. Universities Press. 2010. pp. 236–. ISBN 978-81-7371-679-9.
^ ^a ^b George deStevens; V. Zingel; C. Leschke; W. Schunack, Paul D. Hoeprich, Richard M. Schultz, P.K. Mehrotra, Sanjay Batra, A.P. Bhaduri, Anil K. Saxena, Mridula Saxena (11 November 2013). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Birkhäuser. pp. 217–. ISBN 978-3-0348-7161-7. Cite uses deprecated parameter |coauthors= (help)
^ Dr. S. S. Kadam (1 July 2007). PRINCIPLES OF MEDICINAL CHEMISTRY Vol. - II. Pragati Books Pvt. Ltd. pp. 147–. ISBN 978-81-85790-03-9.

External linksEdit

DDB 34078

MedlinePlus DrugInfo uspdi-202454
Coker S (1986). "The use of phenacemide for intractable partial complex epilepsy in children". Pediatr Neurol 2 (4): 230–2. doi:10.1016/0887-8994(86)90053-6. PMID 3508693.
Coker S, Holmes E, Egel R (1987). "Phenacemide therapy of complex partial epilepsy in children: determination of plasma drug concentrations". Neurology 37 (12): 1861–6. doi:10.1212/wnl.37.12.1861. PMID 3683877.

This anticonvulsant-related article is a stub. You can help Wikipedia by expanding it.

English Journal

A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible?

Andreev E1, Koopman M, Arisz L.
Journal of internal medicine.J Intern Med.1999 Sep;246(3):247-52.
This is a review of the available information about drugs which cause an increase in plasma creatinine concentration without decreasing glomerular filtration rate (GFR). The GFR is the main, but not the single, determinant of the plasma creatinine levels. Several drugs, such as cimetidine, trimethop
PMID 10475992

HPLC assay of Lidocaine in plasma with solid phase extraction and UV detection.

Kang L1, Jun HW, McCall JW.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.1999 Apr;19(5):737-45.
A sensitive and reliable method based on solid-phase extraction and reversed-phase liquid chromatography was developed and validated for the quantitation of Lidocaine (Lid) in dog plasma. Phenacemide was used as an internal standard (IS) in the extraction which employed C18 solid-phase extraction ca
PMID 10698537

Creatinine metabolism impairment by an anticonvulsant drug, phenacemide.

Cahen R1, Martin A, Francois B, Baltassat P, Louisot P.
The Annals of pharmacotherapy.Ann Pharmacother.1994 Jan;28(1):49-51.
OBJECTIVE: To report two cases of increased true serum creatinine (Scr) without renal failure caused by an anticonvulsant drug, phenacemide, and to discuss the possible mechanisms.CASE SUMMARY: Two patients treated with phenacemide were investigated for markedly increased Scr and decreased creatinin
PMID 8123960

Japanese Journal

DIFFERENTIAL ANTAGONISMS OF ANTICONVULSANTS TO VARIOUS COMPONENTS OF MAXIMAL SEIZURES INDUCED BY ELECTROSHOCK OR PENTYLENETETRAZOL IN MICE

MASUDA YOSHINOBU,SHIRAISHI YUKO,KARASAWA TADAHIKO,YOSHIDA KOUICHI,SHIMIZU MASANAO
Journal of pharmacobio-dynamics 3(10), 526-531, 1980-10-00
… drugs (trimethadione, ethosuximide, nitrazepam, diazepam, ethotoin and metharbital) with an effect to antagonize all the whole seizure components (TF, TH and CL or MCL) in an almost same antagonism, 2) drugs (phenacemide, dipropylacetate, pheneturide, acetylpheneturide and phenobarbital) which inhibit all forms of seizures at relatively dissociated doses for the prevention of each component of seizures, 3) drugs (diphenylhydantoin and carbamazepine) which selectively abolish both components (TF and TH) of tonic seizures, and 4) drugs (acetazolamide, …
NAID 110003635788

Clonazepamの中枢作用

小野信文,古川達雄
日本薬理学雑誌 72(3), 297-312, 1976
… On the contrary, the anticonvulsant effect of clonazepam against TE of maximal electroshock seizure evoked by supramaximal current was weak, the potency being 0.71 times weaker than that of phenacemide, 0.14 times than phenytoin and 0.24 times than Phenobarbital. …
NAID 130000758406

新抗癲癇剤Phenuron(Phenacetyl urea,phenacemide)による無顆粒細胞症の経験

高山哲夫 [他]
北海道医学雑誌 30(11・12), ????, 1955-12-00
NAID 40018503196

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拡張検索	「ethylphenacemide」

「ethylphenacemide」

Phenacemide
Systematic (IUPAC) name
	N-carbamoyl-2-phenyl-acetamide
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pharmacokinetic data
Biological half-life	22-25 hours.
Identifiers
CAS Number	63-98-9
ATC code	N03AX07
PubChem	CID 4753
IUPHAR/BPS	7265
DrugBank	DB01121
ChemSpider	4589
UNII	PAI7J52V09
KEGG	D00504
ChEMBL	CHEMBL918
Chemical data
Formula	C9H10N2O2
Molar mass	178.188 g/mol
	SMILES O=C(NC(=O)N)Cc1ccccc1 ;
	InChI InChI=1S/C9H10N2O2/c10-9(13)11-8(12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,10,11,12,13) ; Key:XPFRXWCVYUEORT-UHFFFAOYSA-N ;
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関: pheneturide

[GanellinTriggle1996-1] C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1578–. ISBN 978-0-412-46630-4.

[UniversitiesPress2010-2] Conceptual Pharmacology. Universities Press. 2010. pp. 236–. ISBN 978-81-7371-679-9.

[deStevensZingel2013-3] George deStevens; V. Zingel; C. Leschke; W. Schunack, Paul D. Hoeprich, Richard M. Schultz, P.K. Mehrotra, Sanjay Batra, A.P. Bhaduri, Anil K. Saxena, Mridula Saxena (11 November 2013). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Birkhäuser. pp. 217–. ISBN 978-3-0348-7161-7. Cite uses deprecated parameter |coauthors= (help)

[Kadam2007-4] Dr. S. S. Kadam (1 July 2007). PRINCIPLES OF MEDICINAL CHEMISTRY Vol. - II. Pragati Books Pvt. Ltd. pp. 147–. ISBN 978-81-85790-03-9.

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phenacemide