phase I clinical trial

出典: meddic

第I相臨床試験第一相臨床試験第一相試験

phase 1 clinical trial

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/16 00:03:22」(JST)

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英文文献

  • Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma.
  • Beumer JH1,2, Fu KY3, Anyang BN4, Siegfried JM5, Bakkenist CJ6,7,8.
  • BMC cancer.BMC Cancer.2015 Oct 5;15:649. doi: 10.1186/s12885-015-1649-3.
  • BACKGROUND: ATM and ATR are kinases implicated in a myriad of DNA-damage responses. ATM kinase inhibition radiosensitizes cells and selectively kills cells with Fanconi anemia (FA) gene mutations. ATR kinase inhibition sensitizes cells to agents that induce replication stress and selectively kills c
  • PMID 26438152
  • Safety and immunogenicity of a single intramuscular dose of a tetanus-diphtheria toxoid (Td) vaccine (BR-TD-1001) in healthy Korean adult subjects.
  • Hong T1, Chung YJ2,3, Kim TY2, Kim IH3, Choe YK4, Lee J1, Jeon S1, Han S1, Yim DS1.
  • Human vaccines & immunotherapeutics.Hum Vaccin Immunother.2015 Oct 3;11(10):2440-5. doi: 10.1080/21645515.2015.1054582.
  • BR-TD-1001 was developed as a booster for the immunity maintenance of diphtheria and tetanus. The aim of this study was to evaluate the safety and immunogenicity of BR-TD-1001 (test vaccine) in comparison with placebo and an active comparator in healthy Korean adults. A randomized, double-blind, pla
  • PMID 26091286
  • [Ultrasmall nanoparticles for radiotherapy: AGuIX].
  • Lux F1, Detappe A2, Dufort S3, Sancey L1, Louis C3, Carme S2, Tillement O4.
  • Cancer radiothérapie : journal de la Société française de radiothérapie oncologique.Cancer Radiother.2015 Oct;19(6-7):508-14. doi: 10.1016/j.canrad.2015.05.019. Epub 2015 Sep 3.
  • Since twenty years, many nanoparticles based on high atomic number elements have been developed as radiosensitizers. The design of these nanoparticles is limited by the classical rules associated with the development of nanoparticles for oncology and by the specific ones associated to radiosensitize
  • PMID 26343033

和文文献

  • Safety and efficacy of switching thrice-daily treatment with NovoRapid 70Mix (BIAsp70) to BIAsp70 before breakfast and lunch and NovoRapid 30Mix (BIAsp30) before dinner in patients with type 2 diabetes : subgroup analysis of a phasetrial
  • KADOWAKI Takashi,NISHIDA Tomoyuki,KAKU Kohei
  • Diabetology international 2(4), 183-189, 2012-12-01
  • NAID 10030590111
  • 腎癌分子標的治療の副作用対策 : 新規薬剤の有害事象プロファイル (第61回日本泌尿器科学会中部総会 シンポジウム2「分子標的薬治療の副作用対策」)
  • 野澤 昌弘,植村 天受
  • 泌尿器科紀要 = Acta urologica Japonica 58(11), 655-657, 2012-11
  • … Temsirolimus is an inhibitor of mammalian target of rapamycin, with proven efficacy against advanced renal cell carcinoma (RCC), particularly poor risk and/or non-clear cell RCC, in a randomized first-line phase III trial. … In this trial, adverse events (AEs) ≥grade 3 occurred in47. … During the observation period of this trial, drug-related pneumonitis was detected ; …
  • NAID 40019497617
  • 分子標的薬の副作用 : Temsirolimus (第61回日本泌尿器科学会中部総会 シンポジウム2「分子標的薬治療の副作用対策」)
  • 三宅 秀明,藤澤 正人
  • 泌尿器科紀要 = Acta urologica Japonica 58(11), 651-654, 2012-11
  • … Temsirolimus is an inhibitor of mammalian target of rapamycin, with proven efficacy against advanced renal cell carcinoma (RCC), particularly poor risk and/or non-clear cell RCC, in a randomized first-line phase III trial. … In this trial, adverse events (AEs) ≥grade 3 occurred in47. … During the observation period of this trial, drug-related pneumonitis was detected ; …
  • NAID 40019497603

関連リンク

Phase I Clinical Trial. 動物実験が終わり FDA が臨床試験に移行することを許可したら 、phase I clinical trial に入ります。この phase では健丈人に対して可能性のある毒性 を検討し、耐用量. を決定します。まず何を持って毒性とするかを事前に予測しておき ...
Phase II Clinical Trial. Phase I では安全性を評価したのに対して、phase II では薬効 を評価します。 薬剤に関する phase II trials. (1) 初期用量は phase I study(ies)の結果 より設定します。 (2) 用量は通常増量しません(デザインによる);むしろ 1 人でも患者 ...

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リンク元第一相試験」「phase 1 clinical trial
関連記事phase」「trial」「clinic」「clinical」「I

第一相試験」

  [★]

phase I clinical trial
第一相臨床試験第I相臨床試験


phase 1 clinical trial」

  [★]

phase I clinical trial


phase」

  [★]

  • n.
  • v.
aspectgradeperiodphasedphasicsituationstagesteptime

WordNet   license wordnet

「arrange in phases or stages; "phase a withdrawal"」

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「(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary; "the reaction occurs in the liquid phase of the system"」
form

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「a particular point in the time of a cycle; measured from some arbitrary zero and expressed as an angle」
phase angle

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「any distinct time period in a sequence of events; "we are in a transitional stage in which many former ideas must be revised or rejected"」
stage

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「adjust so as to be in a synchronized condition; "he phased the intake with the output of the machine"」

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「(astronomy) the particular appearance of a body''s state of illumination (especially one of the recurring shapes of the part of Earth''s moon that is illuminated by the sun); "the full phase of the moon"」

PrepTutorEJDIC   license prepejdic

「(変化・発達の)『段階』,『局面』 / (物事の)『面』,様相《+『of』+『名』》 / (月・惑星などの)相 / …‘を'段階的に調整(整理)する」

trial」

  [★]

  • n.
assessmentattemptclinical researchclinical studyclinical testclinical trialeffortexamexaminationexamineinvestigationinvestigationaltentativetentativelytesttesting

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「(law) the determination of a person''s innocence or guilt by due process of law; "he had a fair trial and the jury found him guilty"; "most of these complaints are settled before they go to trial"」

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「trying something to find out about it; "a sample for ten days free trial"; "a trial of progesterone failed to relieve the pain"」
trial run, test, tryout

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「an annoying or frustrating or catastrophic event; "his mother-in-law''s visits were a great trial for him"; "life is full of tribulations"; "a visitation of the plague"」
tribulation, visitation

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「(sports) a preliminary competition to determine qualifications; "the trials for the semifinals began yesterday"」

PrepTutorEJDIC   license prepejdic

「〈U〉〈C〉『裁判』,公判,審理 / 〈U〉〈C〉(…の)『試験』,ためし《+of+名》 / 〈C〉企て,試み;努力 / 〈C〉(忍耐・徳・信仰などをためす)試練,苦難 / 〈C〉困りもの,迷惑な(やっかいな)人(もの)」


clinic」

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  • n.

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「a healthcare facility for outpatient care」

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「a medical establishment run by a group of medical specialists」

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「meeting for diagnosis of problems and instruction or remedial work in a particular activity」

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「〈U〉(医学の)臨床講義 / 〈C〉《集合的に》臨床講義のクラス / 〈C〉臨床講義室 / 〈C〉(病院・医科大学・社会事業団などに付属した)診療所;《形容詞を判って》医療施設,病院 / 〈C〉(警察・学校・社会事業団などに付属した)相談所」


clinical」

  [★]

  • adj.
clinclinically

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「scientifically detached; unemotional; "he spoke in the clipped clinical monotones typical of police testimony"」

PrepTutorEJDIC   license prepejdic

「臨床の,臨床講義の / 病床の / 臨床的な,客観的な態度の」

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「relating to a clinic or conducted in or as if in a clinic and depending on direct observation of patients; "clinical observation"; "clinical case study"」


I」

  [★]

WordNet   license wordnet

「the 9th letter of the Roman alphabet」
i

PrepTutorEJDIC   license prepejdic

「『私は』私が」

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「iodineの化学記号」




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