WordNet
- sometimes the FDA approves a drug for general use but requires the manufacturer to continue to monitor its effects; during this phase the drug may be tried on slightly different patient populations than those studied in earlier trials (同)phase_IV
- arrange in phases or stages; "phase a withdrawal"
- (physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary; "the reaction occurs in the liquid phase of the system" (同)form
- a particular point in the time of a cycle; measured from some arbitrary zero and expressed as an angle (同)phase_angle
- any distinct time period in a sequence of events; "we are in a transitional stage in which many former ideas must be revised or rejected" (同)stage
- adjust so as to be in a synchronized condition; "he phased the intake with the output of the machine"
- (astronomy) the particular appearance of a bodys state of illumination (especially one of the recurring shapes of the part of Earths moon that is illuminated by the sun); "the full phase of the moon"
- (law) the determination of a persons innocence or guilt by due process of law; "he had a fair trial and the jury found him guilty"; "most of these complaints are settled before they go to trial"
- trying something to find out about it; "a sample for ten days free trial"; "a trial of progesterone failed to relieve the pain" (同)trial_run, test, tryout
- an annoying or frustrating or catastrophic event; "his mother-in-laws visits were a great trial for him"; "life is full of tribulations"; "a visitation of the plague" (同)tribulation, visitation
- (sports) a preliminary competition to determine qualifications; "the trials for the semifinals began yesterday"
- a healthcare facility for outpatient care
- a medical establishment run by a group of medical specialists
- meeting for diagnosis of problems and instruction or remedial work in a particular activity
- scientifically detached; unemotional; "he spoke in the clipped clinical monotones typical of police testimony"
- relating to a clinic or conducted in or as if in a clinic and depending on direct observation of patients; "clinical observation"; "clinical case study"
- the 9th letter of the Roman alphabet (同)i
PrepTutorEJDIC
- (変化・発達の)『段階』,『局面』 / (物事の)『面』,様相《+『of』+『名』》 / (月・惑星などの)相 / …‘を'段階的に調整(整理)する
- 〈U〉〈C〉『裁判』,公判,審理 / 〈U〉〈C〉(…の)『試験』,ためし《+of+名》 / 〈C〉企て,試み;努力 / 〈C〉(忍耐・徳・信仰などをためす)試練,苦難 / 〈C〉困りもの,迷惑な(やっかいな)人(もの)
- 〈U〉(医学の)臨床講義 / 〈C〉《集合的に》臨床講義のクラス / 〈C〉臨床講義室 / 〈C〉(病院・医科大学・社会事業団などに付属した)診療所;《形容詞を判って》医療施設,病院 / 〈C〉(警察・学校・社会事業団などに付属した)相談所
- 臨床の,臨床講義の / 病床の / 臨床的な,客観的な態度の
- 『私は』私が
- iodineの化学記号
UpToDate Contents
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English Journal
- Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms.
- Sun J1, Peng Y1, Wu H1, Zhang X1, Zhong Y1, Xiao Y1, Zhang F1, Qi H1, Shang L1, Zhu J1, Sun Y1, Liu K1, Liu J1, A J1, Ho RJ1, Wang G2.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2015 May;43(5):713-24. doi: 10.1124/dmd.114.060905. Epub 2015 Feb 13.
- Guanfu base A (GFA) is a novel heterocyclic antiarrhythmic drug isolated from Aconitum coreanum (Lèvl.) rapaics and is currently in a phase IV clinical trial in China. However, no study has investigated the influence of GFA on cytochrome P450 (P450) drug metabolism. We characterized the potency and
- PMID 25681130
- Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial.
- Martinez FJ1, Calverley PM2, Goehring UM3, Brose M4, Fabbri LM5, Rabe KF6.
- Lancet.Lancet.2015 Mar 7;385(9971):857-66. doi: 10.1016/S0140-6736(14)62410-7. Epub 2015 Feb 13.
- BACKGROUND: Roflumilast reduces exacerbations in patients with severe chronic obstructive pulmonary disease. Its effect in patients using fixed combinations of inhaled corticosteroids and longacting β2 agonists is unknown. We postulated that roflumilast would reduce exacerbations in patients with s
- PMID 25684586
- Outcome of the FUSION vascular graft for above-knee femoropopliteal bypass.
- Assadian A1, Eckstein HH2; Peripheral Bypass Grafting: Prospective Evaluation of FUSION Vascular Graft for Above Knee Targets (PERFECTION) Study Group.
- Journal of vascular surgery.J Vasc Surg.2015 Mar;61(3):713-9.e1. doi: 10.1016/j.jvs.2014.10.005. Epub 2014 Dec 10.
- OBJECTIVE: Although endovascular procedures have become popular for the treatment of patients with femoropopliteal occlusive disease, open surgical bypass is still required in a significant proportion of patients. Saphenous vein is the conduit of choice, but prosthetic bypass grafts are often necess
- PMID 25498193
- Tretinoin Nanogel 0.025% Versus Conventional Gel 0.025% in Patients with Acne Vulgaris: A Randomized, Active Controlled, Multicentre, Parallel Group, Phase IV Clinical Trial.
- Chandrashekhar BS1, Anitha M2, Ruparelia M3, Vaidya P4, Aamir R5, Shah S6, Thilak S7, Aurangabadkar S8, Pal S9, Saraswat A10, Sanmukhani JJ11.
- Journal of clinical and diagnostic research : JCDR.J Clin Diagn Res.2015 Jan;9(1):WC04-9. doi: 10.7860/JCDR/2015/10663.5469. Epub 2015 Jan 1.
- BACKGROUND: Conventional topical tretinoin formulation is often associated with local adverse events. Nanogel formulation of tretinoin has good physical stability and enables good penetration of tretinoin into the pilo-sebaceous glands.AIM: The present study was conducted to assess the efficacy and
- PMID 25738069
Japanese Journal
- CD5陽性びまん性大細胞型B細胞リンパ腫:―分子基盤に基づく治療戦略―
- 宮﨑 香奈
- 臨床血液 56(8), 1038-1044, 2015
- びまん性大細胞型B細胞リンパ腫(diffuse large B-cell lymphoma, DLBCL)の免疫組織化学的サブグループの一つであるCD5+ DLBCLは,診断時年齢中央値は67歳と高齢者に多く,予後不良因子を高率に有し,rituximab導入後も予後不良である。予後不良性の最大の原因として,rituximab導入後も中枢神経系再発/増悪割合が診断後2年時点で13%と高いことが挙げら …
- NAID 130005096276
- わが国における節外性NK/T細胞リンパ腫の治療開発
- 山口 素子
- 臨床血液 56(6), 639-644, 2015
- … NK腫瘍研究会はアジアの研究者と共同で,初発IV期・初回治療後再発・治療抵抗性ENKLに対するSMILE療法の臨床試験(SMILE-PI & PII)を行い,第II相試験の評価可能38例におけるSMILE療法2コースの奏効割合は79%であった。 …
- NAID 130005093095
- 化学療法抵抗性卵巣癌の局所免疫の解析に基づいた,がん免疫逃避を標的とした新規治療戦略(シンポジウム2(腫瘍) 難治性卵巣癌の克服を目指して,第66回日本産科婦人科学会学術講演会講演要旨)
- 濱西 潤三
- 日本産科婦人科學會雜誌 66(11), 2777-2791, 2014-11-01
- … Background: Ovarian cancer is the most lethal gynecologic malignancy in the world and the fourth most common cause of cancer death in women, largely because more than 75% of patients are diagnosed at advanced tumor status (stage III or IV). … The failure of immune therapies in such clinical trials can be partly ascribed to the phenomenon designated as "cancer immune escape", which involves PD-1/PD-L1 signaling. …
- NAID 110009872637
- Temozolomide (TMZ)を中心とした悪性神経膠腫化学療法の世界の現状
- 若林 俊彦
- Neuro-Oncologyの進歩 21(3), 45-50, 2014
- … (WHO grades III and IV) malignant gliomas, especially glioblastoma (GBM), the most common glioma in adults, kills patients within a median time span of a year after diagnosis despite treatment with aggressive surgical resection, chemotherapy, and radiotherapy.In Japan, alkylating agents such as 1- (4-amino-2-methyl-5-pyridiminyl) methyl-3- (2-chloroethyl) -3-nitrosourea (ACNU) and methyl-6-[3- (2-chloroethyl) -3-nitrosoureido] -6-deoxy-alpha-D-glucopyranoside (MCNU) have been used to treatmalignant gliomas for a long time, however, this treatment …
- NAID 130005002163
Related Links
- Thesaurus Legend: Synonyms Related Words Antonyms Noun 1. phase IV clinical trial - sometimes the FDA approves a drug for general use but requires the manufacturer to continue to monitor its effects; during this phase the drug ...
- Phase IV Clinical Trials Report Sample The following excerpt is taken from Chapter 1, “Study Management Structure, Oversight and Strategy.” It discusses departmental roles for setting Phase IV strategy among companies in the US ...
- Clinical Trial Feasibility and Patient Enrollment: Differentiation Through Innovation Commercialization Thank You October Benchmarking Survey Journey Phase IIIb-IV Planning Phase I Phase IIa Phase II-III Phase IIIb-IV Post Launch ...
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- 関
- assessment、attempt、clinical research、clinical study、clinical test、clinical trial、effort、exam、examination、examine、investigation、investigational、tentative、tentatively、test、testing
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- aspect、grade、period、phased、phasic、situation、stage、step、time
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- clinical research、clinical study、clinical test、investigation、investigational、trial
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- clin、clinically