pharmacokinetics

出典: meddic

薬物動態

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「the study of the action of drugs in the body: method and rate of excretion; duration of effect; etc.」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/10/27 22:57:06」(JST)

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英文文献

  • An electrochemical biosensor for clenbuterol detection and pharmacokinetics investigation.
  • Bo B, Zhu X, Miao P, Pei D, Jiang B, Lou Y, Shu Y, Li G.SourceDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China; Department of Biochemistry and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.
  • Talanta.Talanta.2013 Sep 15;113:36-40. doi: 10.1016/j.talanta.2013.03.056. Epub 2013 Mar 30.
  • Clenbuterol is a member of β2 adrenergic agonists, which is widely used not only as a food additive for livestocks, but also a kind of stimulant for athletes; however, the abuse of clenbuterol may pose a significant negative impact on human health. Since it is highly required to develop fast, sensi
  • PMID 23708621
  • Nimodipine nanocrystals for oral bioavailability improvement: Preparation, characterization and pharmacokinetic studies.
  • Fu Q, Sun J, Zhang D, Li M, Wang Y, Ling G, Liu X, Sun Y, Sui X, Luo C, Sun L, Han X, Lian H, Zhu M, Wang S, He Z.SourceSchool of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China.
  • Colloids and surfaces. B, Biointerfaces.Colloids Surf B Biointerfaces.2013 Sep 1;109:161-6. doi: 10.1016/j.colsurfb.2013.01.066. Epub 2013 Mar 28.
  • This study intended to develop nimodipine (NMD) nanocrystals with different sizes for oral administration and to investigate the relationship between dissolution and pharmacokinetics for NMD nanocrystals and Nimotop(®). NMD nanocrystals were prepared by combination of microprecipitation and high pr
  • PMID 23668980
  • Hepatic biotransformation of alkylresorcinols is mediated via cytochrome P450 and β-oxidation: a proof of concept study.
  • Marklund M, McKeown NM, Blumberg JB, Chen CY.SourceJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA.
  • Food chemistry.Food Chem.2013 Aug 15;139(1-4):925-30. doi: 10.1016/j.foodchem.2013.01.122. Epub 2013 Feb 13.
  • Alkylresorcinols (AR) are phenolic lipids present in the bran of some cereals. AR may serve as a biomarker for whole grain wheat and rye intake. While AR pharmacokinetics and two major metabolites have been reported, the metabolic pathways contributing to their relatively rapid elimination from the
  • PMID 23561191

和文文献

  • Pharmacogenetics and Circadian exposure of Tacrolimus and Its Impact on the renal Transplant Outcome: A Way to a Personalized Medicine for Tacrolimus
  • Satoh Shigeru,Saito Mitsuru,Numakura Kazuyuki,Miura Yoshio,Inoue Takamitsu,Maita Shinya,Obara Takashi,Tsuruta Hiroshi,Narita Shintaro,Horikawa Yohei,Tsuchiya Norihiko,Habuchi Tomonori,Mitobe Yoko,Komatsuda Atsushi,Kagaya Hideaki,Miura Masatomo
  • 弘前医学 64(Supplement), S19-S27, 2013-04-02
  • … Tacrolimus has a narrow therapeutic range, and its pharmacokinetics differs greatly among individuals. … Many factors may affect the pharmacokinetics of tacrolimus, including CYP3A5 genotypes. … Before staring the personalize medicine for controlled-release tacrolimus, we analyzed circadian pharmacokinetics and pharmacogenetics of twice daily tacrolimus, and its association with transplant outcome. …
  • NAID 120005230048
  • Effect of Cytochrome P450 2C8*3 on the Population Pharmacokinetics of Pioglitazone in Healthy Caucasian Volunteers
  • Kadam Rajendra,Bourne David,Kompella Uday [他]
  • Biological & pharmaceutical bulletin 36(2), 245-251, 2013-02-00
  • NAID 40019558494
  • 抗MRSA薬の薬物動態解析と適正使用に関する研究

関連リンク

Pharmacokinetics may be simply defined as what the body does to the drug, as opposed to pharmacodynamics which may be defined as what the drug does to the body. “ ” Leslie Z. Benet, Pharmacokinetics: Basic Principles and Its Use as a ...
詳細およびメンテナンス予定は、こちらからご覧ください。 Internet Explorer 8 でのご 利用について. J-STAGEにおいて Internet Explorer 8 で一部不具合が発生する場合が 報告されております。詳細は、こちらをご確認ください。 編集, : 日本薬物動態学会 DMPK ...

関連画像

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★リンクテーブル★
リンク元薬物動態」「薬動学」「PK/PD理論」「薬物動態学」「薬物速度論
関連記事pharmacokinetic

薬物動態」

  [★]

pharmacokinetics
A D M E
吸収 分布 代謝 排出
血流量 組織血流量 肝血流量 腎血流量
消化管運動 アルブミン濃度 酵素活性 尿pH
消化管pH
  • 投与経路
血中濃度のピークの投与からの早さ:静注(i.v.)>筋注(i.m.)>皮下(s.c.)>経口(p.o.)
血中濃度のピークの高さ     :静注(i.v.)>筋注(i.m.)>皮下(s.c.)>経口(p.o.)
  • 年齢と薬物代謝
高齢者ほど血中濃度が高くなる。経口投与において顕著。
  • 年齢と血中濃度
高齢者ほど血中薬物濃度の半減期が長くなる
  • 薬物の脂溶性
脂溶性が高いものほどよく吸収される→組織移行性がよい
  • 消化管運動
消化管運動があると薬物の吸収が良くなる
  • 薬物の解離度とpH (GOO. 2)
an acidic drug will accumulate on the more basic side of the membrane and a basic drug on the more acidic side
  • 血液のpH




薬動学」

  [★]

pharmacokinetics
ファーマコキネティクス
トキシコキネティクス薬物速度論薬物動態薬物動態学


PK/PD理論」

  [★]

PK/PD theory
薬物動態学 pharmacokinetics PK薬力学 pharmacodynamics PD


薬物動態学」

  [★]

pharmacokinetics
薬動学薬物速度論薬物動態



薬物速度論」

  [★]

pharmacokinetics
薬動学薬物動態薬物動態学


pharmacokinetic」

  [★]

  • adj.
  • 薬物動態学的な
pharmacokinetically




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