pharmacogenetics

出典: meddic

薬理遺伝学

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「the branch of genetics that studies the genetically determined variations in responses to drugs in humans or laboratory organisms」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/01/09 00:48:15」(JST)

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英文文献

  • DNA methylation dynamics in the hepatic CYP3A4 gene promoter.
  • Kacevska M, Ivanov M, Wyss A, Kasela S, Milani L, Rane A, Ingelman-Sundberg M.SourceSection of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address: marina.kacevska@ki.se.
  • Biochimie.Biochimie.2012 Nov;94(11):2338-44. doi: 10.1016/j.biochi.2012.07.013. Epub 2012 Jul 31.
  • The CYP3A4 gene, encoding the major drug metabolizing enzyme in humans, exhibits a high interindividual variation in hepatic expression that can lead to interindividual differences in drug metabolism and associated adverse drug effects. Much of the interindividual variability in CYP3A4 remains unexp
  • PMID 22906825
  • Understanding the Critical Disposition Pathways of Statins to Assess Drug-Drug Interaction Risk During Drug Development: It's Not Just About OATP1B1.
  • Elsby R, Hilgendorf C, Fenner K.SourceGlobal DMPK-In Vitro/In Silico ADME, AstraZeneca R&D Alderley Park, Cheshire, UK.
  • Clinical pharmacology and therapeutics.Clin Pharmacol Ther.2012 Nov;92(5):584-98. doi: 10.1038/clpt.2012.163. Epub 2012 Oct 10.
  • The use of statins is widespread across disease areas because many patients have comorbidities. Given that these drugs have become common as comedications, it is essential to have an understanding of the potential risks of drug-drug interactions (DDIs) between statins and candidate drugs in developm
  • PMID 23047648

和文文献

  • Use of pharmacogenetics for predicting cancer prognosis and treatment exposure, response and toxicity (Special Section on Pharmacogenomics : recent advances and future directions)
  • Hertz Daniel L,McLeod Howard L
  • Journal of human genetics 58(6), 346-352, 2013-06
  • NAID 40019670596
  • Pharmacogenetics of warfarin : challenges and opportunities (Special Section on Pharmacogenomics : recent advances and future directions)
  • Lee Ming Ta Michael,Klein Teri E
  • Journal of human genetics 58(6), 334-338, 2013-06
  • NAID 40019670579
  • 癌幹細胞を標的とした革新的な医療の創出 (第74回日本血液学会学術集会 : シンポジウム3 Myeloid Malignancies in a New Era of Molecularly Targeted Therapy)
  • 石井 秀始,今野 雅允,賀川 義規 [他]
  • 臨床血液 54(5), 415-422, 2013-05
  • NAID 40019693883

関連リンク

Pharmacogenomicsは新薬開発に有用な遺伝子情報の学問と言えます。例えば、高血圧の原因となる多数の因子(受容体)の遺伝子の変異を新たに発見して、それを標的として薬を開発しようとするものです。したがって、従来は「血圧が高い ...
Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects. [1] The term pharmacogenetics is ...

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PHARMACOGENETICS IN PSYCHIATRY , genotyping and pharmacogeneticspharmacogenetics by manilachamarapharmacogenetics [licensed for non PharmacogeneticsPharmacogenetics helps in identifying


★リンクテーブル★
リンク元薬理遺伝学」「pharmacogenetical
関連記事pharmacogenetic

薬理遺伝学」

  [★]

pharmacogenetics
遺伝薬理学
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pharmacogenetical」

  [★]

  • 遺伝薬理学的な、遺伝薬理学の
pharmacogeneticpharmacogenetics

pharmacogenetic」

  [★]

  • adj.
  • 遺伝薬理学的な、遺伝薬理学の
pharmacogeneticalpharmacogenetics




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