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1. 結核の免疫学immunology of tuberculosis [show details]
…strategies include: Resistance to reactive oxygen intermediates (ROIs) Inhibition of phagosome-lysosome fusion; Inhibition of phagosome acidification; Escape from the phagosomal compartment into the cytoplasmic …
2. ノカルジア症の微生物学、疫学、および病因microbiology epidemiology and pathogenesis of nocardiosis [show details]
…filamentous growth and are resistant to phagocytosis. When phagocytosis does occur, inhibition of phagosome-lysosome fusion has been observed with some nocardial strains, thereby avoiding hydrolysis by the…
3. 抗原提示細胞antigen presenting cells [show details]
4. 非結核性抗酸菌感染症の病因pathogenesis of nontuberculous mycobacterial infections [show details]
…the phagocytes are not primed to kill the bacteria. Bound mycobacteria are taken up in primary phagosomes that fuse with vacuoles in the phagocyte cytoplasm and attempt to destroy its contents through …
5. ツツガ虫病：臨床的特徴および診断scrub typhus clinical features and diagnosis [show details]
…phospholipase A2 appears to be involved as a mediator of entry into host cells with subsequent release from phagosomes and injury to the host cell . Organisms disseminate widely after initial inoculation into the…

English Journal

Lipid-labeling facilitates a novel magnetic isolation procedure to characterize pathogen-containing phagosomes.

Steinhäuser C, Heigl U, Tchikov V, Schwarz J, Gutsmann T, Seeger K, Brandenburg J, Fritsch J, Schroeder J, Wiesmüller KH, Rosenkrands I, Walther P, Pott J, Krause E, Ehlers S, Schneider-Brachert W, Schütze S, Reiling N.SourceDivision of Microbial Interface Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, 23845, Germany.
Traffic (Copenhagen, Denmark).Traffic.2013 Mar;14(3):321-36. doi: 10.1111/tra.12031. Epub 2012 Dec 28.
Here we describe a novel approach for the isolation and biochemical characterization of pathogen-containing compartments from primary cells: We developed a lipid-based procedure to magnetically label the surface of bacteria and visualized the label by scanning and transmission electron microscopy (S
PMID 23231467

Winterbourn CC, Kettle AJ.SourceCentre for Free Radical Research, Department of Pathology, University of Otago Christchurch , Christchurch, New Zealand .
Antioxidants & redox signaling.Antioxid Redox Signal.2013 Feb 20;18(6):642-60. doi: 10.1089/ars.2012.4827. Epub 2012 Oct 9.
Abstract Significance: When neutrophils kill microorganisms, they ingest them into phagosomes and bombard them with a burst of reactive oxygen species. Recent Advances: This review focuses on what oxidants are produced and how they kill. The neutrophil NADPH oxidase is activated and shuttles elect
PMID 22881869

New insights into the regulation of neutrophil NADPH oxidase activity in the phagosome: a focus on the role of lipid and ca(2+) signaling.

Bréchard S, Plançon S, Tschirhart EJ.SourceCalcium Signaling and Inflammation Group, Life Sciences Research Unit, University of Luxembourg , Luxembourg, Luxembourg .
Antioxidants & redox signaling.Antioxid Redox Signal.2013 Feb 20;18(6):661-76. doi: 10.1089/ars.2012.4773. Epub 2012 Sep 18.
Abstract Significance: Reactive oxygen species, produced by the phagosomal NADPH oxidase of neutrophils, play a significant physiological role during normal defense. Their role is not only to kill invading pathogens, but also to act as modulators of global physiological functions of phagosomes. Gi
PMID 22867131

Ultrastructural Patterns of Interactions between Murine Lung Macrophages and Yeast Cells of <I>Cryptococcus neoformans</I> Strains with Different Virulence

Stepanova Amaliya,Vasilyeva Natalia,Yamaguchi Masashi,Chibana Hiroji,Bosak Iliya,Filippova Larisa
Medical Mycology Journal 59(1), E1-E6, 2018
… 2) become partly free from their capsules, destroy the phagosomal plasma membrane and induce destructive processes inside the macrophage causing their death (second scenario); …
NAID 130006406355

Electron microscopic identification of hydrogen peroxide detected in fixed human polymorphonuclear leukocytes during phagocytosis

MORIGUCHI Keiichi,OHNO Norikazu
Okajimas Folia Anatomica Japonica 90(4), 97-100, 2014
… When PMNs engulfed particles, free radical-producing vesicles had enhanced reaction deposits 10 min later and fused to the phagosomal membrane, releasing numerous free radicals into the lumen. …
NAID 130004495132