perlapine

English Journal

Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors.

Seeman P, Tallerico T.SourceDepartment of Pharmacology, University of Toronto, Canada.
Molecular psychiatry.Mol Psychiatry.1998 Mar;3(2):123-34.
This review addresses two questions. First, why does clozapine apparently occupy low levels of dopamine D2 receptors in patients, in contrast to all other antipsychotic drugs which occupy 70-80% of brain dopamine D2 receptors Second, what is the receptor basis of action of antipsychotic drugs which
PMID 9577836

Discriminative-stimulus effects of clozapine in squirrel monkeys: comparison with conventional and novel antipsychotic drugs.

Carey GJ, Bergman J.SourceNew England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA.
Psychopharmacology.Psychopharmacology (Berl).1997 Aug;132(3):261-9.
The effects of conventional and novel atypical antipsychotic drugs were compared to clozapine in squirrel monkeys that discriminated I.M. injections of clozapine (1.0 mg/kg) from saline in a two-lever drug discrimination procedure. Clozapine (0.03-3.0 mg/kg) produced dose-related increases in respon
PMID 9292626

Dopamine and Serotonin Receptors : Amino Acid Sequences, and Clinical Role in Neuroleptic Parkinsonism