English Journal

Pericytoma with t(7;12) and ACTB-GLI1 fusion arising in bone.

Bridge JA, Sanders K, Huang D, Nelson M, Neff JR, Muirhead D, Walker C, Seemayer TA, Sumegi J.Author information Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA. jbridge@unmc.eduAbstractCytogenetic analysis of a primary bone neoplasm with pericytic features in a 67-year-old man revealed a t(7;12)(p22;q13) among other karyotypic abnormalities. Subsequent molecular studies confirmed the presence of an associated ACTB-GLI1 fusion transcript. An identical 7;12 translocation is known to characterize a discrete group of soft tissue tumors belonging to the myopericytic category termed pericytoma with t(7;12). To the best of our knowledge, this is the first case of pericytoma with t(7;12) arising in bone. Cytogenetic and molecular analyses were useful, if not essential, in classifying this rare diagnostic entity.
Human pathology.Hum Pathol.2012 Sep;43(9):1524-9. doi: 10.1016/j.humpath.2012.01.019. Epub 2012 May 9.
Cytogenetic analysis of a primary bone neoplasm with pericytic features in a 67-year-old man revealed a t(7;12)(p22;q13) among other karyotypic abnormalities. Subsequent molecular studies confirmed the presence of an associated ACTB-GLI1 fusion transcript. An identical 7;12 translocation is known to
PMID 22575261

Spontaneous Subcutaneous Sarcoma in a 50-week-old Male Wistar Hannover GALAS Rat.

Onozato T, Tamura T, Nagasawa T, Hayashi M, Okuhara Y, Kuroda J.Author information Toxicology Research Laboratory, R&D, Kissei Pharmaceutical Co., Ltd., 2320-1 Maki, Hotaka, Azumino, Nagano 399-8305, Japan.AbstractA subcutaneous mass was noted in the abdomen of a 50-week-old male Wistar Hannover GALAS rat. Histologically, the tumor was composed of vimentin-positive small round cells with scant cytoplasm arranged in a trabecular, sheet or pericytoma-like pattern and spindle cells arranged in a bundle pattern and vimentin-negative round cells proliferating in an island-shaped pattern. Argentophilic thin fibers were observed to wrap up the individual cells, and some of the tumor cells showed coexpression of vimentin and cytokeratin that formed juxtanuclear globes in the cytoplasm by double immunohistostaining. Transmission electron microscopy did not reveal any characteristic features suggesting cellular differention toward a specific cell type. Based on these findings, it was difficult to specify the origin, and the tumor was diagnosed as a poorly differentiated mesenchymal tumor and classified as a sarcoma, NOS (not otherwise specified).
Journal of toxicologic pathology.J Toxicol Pathol.2011 Dec;24(4):239-44. doi: 10.1293/tox.24.239. Epub 2012 Jan 7.
A subcutaneous mass was noted in the abdomen of a 50-week-old male Wistar Hannover GALAS rat. Histologically, the tumor was composed of vimentin-positive small round cells with scant cytoplasm arranged in a trabecular, sheet or pericytoma-like pattern and spindle cells arranged in a bundle pattern a
PMID 22319237

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.

Lauth M, Bergström A, Shimokawa T, Toftgård R.Author information Department of Biosciences and Nutrition, Karolinska Institutet, Novum Research Park, Hälsovägen 7, SE-141 57 Huddinge, Sweden.AbstractThe developmentally important Hedgehog (Hh) signaling pathway has recently been implicated in several forms of solid cancer. Current drug development programs focus on targeting the protooncogene Smoothened, a key transmembrane pathway member. These drug candidates, albeit promising, do not address the scenario in which pathway activation occurs downstream of Smoothened, as observed in cases of medulloblastoma, glioma, pericytoma, breast cancer, and prostate cancer. A cellular screen for small-molecule antagonists of GLI-mediated transcription, which constitutes the final step in the Hh pathway, revealed two molecules that are able to selectively inhibit GLI-mediated gene transactivation. We provide genetic evidence of downstream pathway blockade by these compounds and demonstrate the ineffectiveness of upstream antagonists such as cyclopamine in such situations. Mechanistically, both inhibitors act in the nucleus to block GLI function, and one of them interferes with GLI1 DNA binding in living cells. Importantly, the discovered compounds efficiently inhibited in vitro tumor cell proliferation in a GLI-dependent manner and successfully blocked cell growth in an in vivo xenograft model using human prostate cancer cells harboring downstream activation of the Hh pathway.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2007 May 15;104(20):8455-60. Epub 2007 May 9.
The developmentally important Hedgehog (Hh) signaling pathway has recently been implicated in several forms of solid cancer. Current drug development programs focus on targeting the protooncogene Smoothened, a key transmembrane pathway member. These drug candidates, albeit promising, do not address
PMID 17494766

Japanese Journal

Spontaneous Subcutaneous Sarcoma in a 50-week-old Male Wistar Hannover GALAS Rat

Onozato Tomoya,Tamura Toru,Nagasawa Tatsuya,Hayashi Morimichi,Okuhara Yuji,Kuroda Junji
Journal of Toxicologic Pathology 24(4), 239-244, 2011
… Histologically, the tumor was composed of vimentin-positive small round cells with scant cytoplasm arranged in a trabecular, sheet or pericytoma-like pattern and spindle cells arranged in a bundle pattern and vimentin-negative round cells proliferating in an island-shaped pattern. …
NAID 130001884728

成人の下顎歯肉に発生した筋線維腫の1例

津山泰彦,三橋健一郎,森良之,安部貴大,江口智明,高戸毅
日本口腔外科学会雑誌 47(5), 305-308, 2001-05-20
… A pericytoma-like pattern was found in the center of the tumor. …
NAID 10009459836

Congenital hemangiopericytoma の 1 例

阪本靖介,佐伯守洋,中野美和子,黒田達夫,金城僚,鳥飼源史
日本小児外科学会雑誌 35(2), 231-236, 1999-04-20
Congenital (Infantile) hemangiopericytomaは生後1年までに生じる予後良好な腫瘍として, 年長児, 成人に認められるhemangiopericytomaとは区別して報告されてきた.現在まで本邦では調べ得た限り24例報告されており, 稀な腫瘍と考えられる.病理組織学的には成人型と同様に悪性所見を示すことが多いが, 臨床的悪性度は低く, この病理組織学的悪性度と臨 …
NAID 110002121290