関: perforant path

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a trodden path (同)footpath

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道,小道(path)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/01 13:54:51」(JST)

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In the brain, the perforant path or perforant pathway, provides a connectional route from the entorhinal cortex^[1] to all fields of the hippocampal formation, including the dentate gyrus, all CA fields (including CA1),^[2] and the subiculum.

Though it arises mainly from entorhinal layers II and III, the perforant path comprises a smaller component that originates in deep layers V and VI. There is a major dichotomy with respect to the laminar origin and related terminal distribution: neurons in layer II (and possibly layer VI) project to the dentate gyrus and CA3, whereas layer III (and possibly layer V) cells project to CA1 and the subiculum via the temporoammonic pathway.^[3]

In addition to playing a role in spatial memory learning generally, the temporoammonic branch (TA-CA1) of the perforant path mediates spatial memory consolidation.^[4] The temporoammonic pathway has also been implicated in stress-based animal models of depression.^[5]

It may also play a role in temporal lobe seizures.^[6]

In rats

In rats, pyramidal and stellate cells in layer II of entorhinal cortex project through the subiculum of the hippocampus, giving rise to the name "perforant pathway". These glutamatergic fibers form a laminar pattern and terminate in the dentate gyrus and cornu ammonis 3 (CA3) region of the hippocampus. Fibers arising in the lateral portions of the entorhinal cortex show enkephalin immunoreactivity, whereas medial portions appear to contain cholecystokinin. Additionally, pyramidal cells in layer III of the entorhinal cortex send topographic projections along the perforant pathway which branch into the subiculum and CA1.^{[citation needed]}

In mice

In mice, the projection to CA1, and the subiculum all come primarily from EC layer III.^{[citation needed]}

According to Suh et al. (2011 Science 334:1415) the projection to CA3 and dentate gyrus in mice is primarily from layer II of entorhinal cortex, and forms a trisynaptic path with hippocampus (dentate gyrus to CA3 to CA1), distinguished from the direct (monosynaptic) perforant path from Layer III of entorhinal cortex to CA1 and subiculum.^{[citation needed]}

References

^ Witter, Menno P.; Naber, Pieterke A.; Van Haeften, Theo; Machielsen, Willem C.M.; Rombouts, Serge A.R.B.; Barkhof, Frederik; Scheltens, Philip; Lopes Da Silva, Fernando H. (2000). "Cortico-hippocampal communication by way of parallel parahippocampal-subicular pathways". Hippocampus 10 (4): 398. doi:10.1002/1098-1063(2000)10:4<398::AID-HIPO6>3.0.CO;2-K. PMID 10985279.
^ Vago, David R.; Kesner, Raymond P. (2008). "Disruption of the direct perforant path input to the CA1 subregion of the dorsal hippocampus interferes with spatial working memory and novelty detection". Behavioural Brain Research 189 (2): 273. doi:10.1016/j.bbr.2008.01.002. PMID 18313770.
^ Witter, Menno P.; Naber, Pieterke A.; Van Haeften, Theo; Machielsen, Willem C.M.; Rombouts, Serge A.R.B.; Barkhof, Frederik; Scheltens, Philip; Lopes Da Silva, Fernando H. (2000). "Cortico-hippocampal communication by way of parallel parahippocampal-subicular pathways". Hippocampus 10 (4): 398. doi:10.1002/1098-1063(2000)10:4<398::AID-HIPO6>3.0.CO;2-K. PMID 10985279.
^ Remondes, Miguel; Schuman, Erin M. (2004). "Role for a cortical input to hippocampal area CA1 in the consolidation of a long-term memory". Nature 431 (7009): 699. Bibcode:2004Natur.431..699R. doi:10.1038/nature02965. PMID 15470431.
^ Kallarackal, A. J.; Kvarta, M. D.; Cammarata, E.; Jaberi, L.; Cai, X.; Bailey, A. M.; Thompson, S. M. (2013). "Chronic Stress Induces a Selective Decrease in AMPA Receptor-Mediated Synaptic Excitation at Hippocampal Temporoammonic-CA1 Synapses". Journal of Neuroscience 33 (40): 15669. doi:10.1523/JNEUROSCI.2588-13.2013. PMID 24089474.
^ Scimemi, A.; Schorge, S; Kullmann, D. M.; Walker, M. C. (2005). "Epileptogenesis is Associated with Enhanced Glutamatergic Transmission in the Perforant Path". Journal of Neurophysiology 95 (2): 1213–20. doi:10.1152/jn.00680.2005. PMID 16282203.

Shepherd, GM. The Synaptic Organization of the Brain. New York: Oxford University Press. 1998.^{[page needed]}

External links

http://thebrain.mcgill.ca/flash/a/a_07/a_07_cl/a_07_cl_tra/a_07_cl_tra.html^{[full citation needed]}

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「perforant path」

Perforant path
	Diagram of hippocampal regions. DG: Dentate gyrus. Perforant path not labeled, but would arise from the right.
Details
Latin	Tractus perforans
Identifiers
NeuroNames	hier-2686
Dorlands; /Elsevier	p_09/12620687
	Anatomical terms of neuroanatomy