WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion
amide combining the amino group of one amino acid with the carboxyl group of another; usually obtained by partial hydrolysis of protein

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Gonadotropin-releasing hormone receptors as molecular therapeutic targets in prostate cancer: Current options and emerging strategies.

Limonta P, Manea M.SourceDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy. Electronic address: patrizia.limonta@unimi.it.
Cancer treatment reviews.Cancer Treat Rev.2013 Oct;39(6):647-63. doi: 10.1016/j.ctrv.2012.12.003. Epub 2013 Jan 3.
Prostate cancer is androgen-dependent in its early stages and androgen deprivation therapy represents the most effective first-line therapeutic approach. However, after an initial remission, prostate cancer progresses towards the castration resistant prostate cancer (CRPC) stage, with increased mali
PMID 23290320

La Montagna R, Caligiuri I, Giordano A, Rizzolio F.SourceSbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania; Human Health Foundation, Terni and Spoleto (PG), Italy.
Journal of cellular physiology.J Cell Physiol.2013 Sep;228(9):1799-801. doi: 10.1002/jcp.24316.
Pin1 is a unique enzyme that can isomerize specific phospho-Ser/Thr-Pro peptide bonds, inducing a conformational change in the target protein. Such activity represents a novel and tightly controlled signaling mechanism regulating a spectrum of protein functions during the normal physiology of the ce
PMID 23280577

Cowpox virus employs a two-pronged strategy to outflank MHCI antigen presentation.

McCoy WH 4th, Wang X, Yokoyama WM, Hansen TH, Fremont DH.SourceDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, United States. mccoyw@wusm.wustl.edu
Molecular immunology.Mol Immunol.2013 Sep;55(2):156-8. doi: 10.1016/j.molimm.2012.11.011. Epub 2013 Jan 10.
Smallpox decimated humanity for thousands of years before being eradicated by vaccination, a success facilitated by the fact that humans are the only host of variola virus. In contrast, other orthopoxviruses such as cowpox virus can infect a variety of mammalian species, although its dominant reserv
PMID 23312338

Structure–activity relationship study on senktide for development of novel potent neurokinin-3 receptor selective agonists

Misu Ryosuke,Yamamoto Koki,Yamada Ai,Noguchi Taro,Ohno Hiroaki,Yamamura Takashi,Okamura Hiroaki,Matsuda Fuko,Ohkura Satoshi,Oishi Shinya,Fujii Nobutaka
MedChemComm 6(3), 469-476, 2015-01-05
… Neurokinin B (NKB) regulates the secretion of gonadotropin-releasing hormone (GnRH) in the hypothalamus via activation of the cognate neurokinin-3 receptor (NK3R). … Here, we report a comprehensive structure–activity relationship study on the NK3R-selective agonist peptide, senktide. … Substitution of the N-terminal succinyl-Asp substructure in senktide with oxalyl-Glu, oxalyl-D-Glu or oxalyl-L-2-aminoadipic acid (Aad) increased receptor binding and NK3R activation. …
NAID 120005615647

Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration

Fujiwara Kaori,Inoue Takuya,Yorifuji Naoki,Iguchi Munetaka,Sakanaka Taisuke,Narabayashi Ken,Kakimoto Kazuki,Nouda Sadaharu,Okada Toshihiko,Ishida Kumi,Abe Yosuke,Masuda Daisuke,Takeuchi Toshihisa,Fukunishi Shinya,Umegaki Eiji,Akiba Yasutada,Kaunitz Jonathan D.,Higuchi Kazuhide
Journal of Clinical Biochemistry and Nutrition advpub(0), 2015
… The gut incretin glucagon-like peptide-1 (GLP-1) and the intestinotropic hormone GLP-2 are released from enteroendocrine L cells in response to ingested nutrients. … The reduction of ulcers by ED and STG was reversed by co-administration of the GLP-2 receptor antagonist. …
NAID 130004879390

Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration

Fujiwara Kaori,Inoue Takuya,Yorifuji Naoki,Iguchi Munetaka,Sakanaka Taisuke,Narabayashi Ken,Kakimoto Kazuki,Nouda Sadaharu,Okada Toshihiko,Ishida Kumi,Abe Yosuke,Masuda Daisuke,Takeuchi Toshihisa,Fukunishi Shinya,Umegaki Eiji,Akiba Yasutada,Kaunitz Jonathan D.,Higuchi Kazuhide
Journal of Clinical Biochemistry and Nutrition 56(2), 155-162, 2015
… The gut incretin glucagon-like peptide-1 (GLP-1) and the intestinotropic hormone GLP-2 are released from enteroendocrine L cells in response to ingested nutrients. … The reduction of ulcers by ED and STG was reversed by co-administration of the GLP-2 receptor antagonist. …
NAID 130004879376