peptide elongation factor

• ペプチド伸長因子、ポリペプチド鎖伸長因子

関

elongation factor

WordNet

1. be a contributing factor; "make things factor into a companys profitability"
2. any of the numbers (or symbols) that form a product when multiplied together
3. an independent variable in statistics
4. anything that contributes causally to a result; "a number of factors determined the outcome"
5. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
6. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
7. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
8. a concept whose truth can be proved; "scientific hypotheses are not facts"
9. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
10. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
11. an addition to the length of something (同)extension
12. the act of lengthening something
13. the quality of being elongated
14. amide combining the amino group of one amino acid with the carboxyl group of another; usually obtained by partial hydrolysis of protein

PrepTutorEJDIC

1. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
2. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
3. 〈U〉伸長,延長 / 〈C〉伸長部,延長部

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/18 21:15:37」(JST)

wiki en

[Wiki en表示]

Elongation factors are a set of proteins that are used in protein synthesis in the process of cell cycle and elongation in some cells. In the ribosome, they facilitate translational elongation, from the formation of the first peptide bond to the formation of the last one.

Elongation is the most rapid step in translation:

• in prokaryotes it proceeds at a rate of 15 to 20 amino acids added per second (about 60 nucleotides per second)
• in eukaryotes the rate is about two amino acids per second.

Elongation factors play a role in orchestrating the events of this process, and in ensuring the 99.99% accuracy of translation at this speed.

Elongation factors are also a target for pathogen toxins. Corynebacterium diphtheriae produces the diphtheria toxin that alters protein function in the host by inactivating elongation factor (EF-2). This causes pharyngitis and pseudomembranous inflammation in the throat.

Pseudomonas aeruginosa's exotoxin A also inhibits EF-2.

See also

• Prokaryotic elongation factors
• Archaeal elongation factors
• Eukaryotic elongation factors
• GTP-binding elongation factor family, EF-Tu/EF-1A subfamily

References

• Alberts, B. et al. (2002). Molecular Biology of the Cell, 4th ed. New York: Garland Science. ISBN 0-8153-3218-1
• Berg, J. M. et al. (2002). Biochemistry, 5th ed. New York: W.H. Freeman and Company. ISBN 0-7167-3051-0
• Singh, B. D. (2002). Fundamentals of Genetics, New Delhi, India: Kalyani Publishers. ISBN 81-7663-109-4

External links

• Elongation Factor at the US National Library of Medicine Medical Subject Headings (MeSH)
• EC 3.6.5.3

UpToDate Contents

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• 1. 直接トロンビン阻害剤および直接Xa因子阻害剤による抗凝固療法 anticoagulation with direct thrombin inhibitors and direct factor xa inhibitors
• 2. 心不全におけるナトリウム利尿ペプチド測定 natriuretic peptide measurement in heart failure
• 3. 血友病患者における第VIIIおよび第IX因子阻害物質 factor viii and factor ix inhibitors in patients with hemophilia
• 4. von Willebrand因子の生物学および正常機能 biology and normal function of von willebrand factor
• 5. 止血の概要 overview of hemostasis

English Journal

• Roles of mechanistic target of rapamycin and transforming growth factor-β signaling in the molting gland (Y-organ) of the blackback land crab, Gecarcinus lateralis.

• Abuhagr AM1, MacLea KS1, Mudron MR1, Chang SA2, Chang ES2, Mykles DL3.
• Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.Comp Biochem Physiol A Mol Integr Physiol.2016 Aug;198:15-21. doi: 10.1016/j.cbpa.2016.03.018. Epub 2016 Mar 31.
• Molting in decapod crustaceans is controlled by molt-inhibiting hormone (MIH), an eyestalk neuropeptide that suppresses production of ecdysteroids by a pair of molting glands (Y-organs or YOs). Eyestalk ablation (ESA) activates the YOs, which hypertrophy and increase ecdysteroid secretion. At mid pr
• PMID 27040186

• Intrauterine growth restriction inhibits expression of eukaryotic elongation factor 2 kinase, a 1 regulator of protein translation.

• McKnight RA1, Yost CC2, Zinkhan EK3, Fu Q4, Callaway CW3, Fung CM3.
• Physiological genomics.Physiol Genomics.2016 Jun 17:physiolgenomics.00045.2016. doi: 10.1152/physiolgenomics.00045.2016. [Epub ahead of print]
• Nutrient deprivation suppresses protein synthesis by blocking peptide elongation. Transcriptional upregulation and activation of eukaryotic elongation factor 2 kinase (eEF2K) blocks peptide elongation by phosphorylating eukaryotic elongation factor 2 (eEF2). Previous studies examining placentas from
• PMID 27317589

• The SBT6.1 subtilase processes the GOLVEN1 peptide controlling cell elongation.

• Ghorbani S1, Hoogewijs K2, Pečenková T1, Fernandez A1, Inzé A1, Eeckhout D1, Kawa D1, De Jaeger G1, Beeckman T1, Madder A2, Van Breusegem F1, Hilson P3.
• Journal of experimental botany.J Exp Bot.2016 Jun 16. pii: erw241. [Epub ahead of print]
• The GOLVEN (GLV) gene family encode small secreted peptides involved in important plant developmental programs. Little is known about the factors required for the production of the mature bioactive GLV peptides. Through a genetic suppressor screen in Arabidopsis thaliana, two related subtilase genes
• PMID 27315833

Japanese Journal

• Eukaryotic Elongation Factor 1A2 (eEF1A2) Participates in the Expression of Antiadhesive Effect of FNIII14, a Peptide Derived from Fibronectin

• Peptide
• NAID 10030204401

• Eukaryotic Translation Elongation Factor (eEF1A) Serves as a Membrane Receptor Mediating Anti-Adhesive Effect of Peptide FNIII14

• Peptide
• NAID 10030204047

• フィブロネクチン分子由来インテグリン機能抑制性ペプチドの相互作用部位の予測

• 研究報告バイオ情報学（BIO） 2011-BIO-27(12), 1-6, 2011-11-24
• NAID 110008694774

Related Links

• Elongation factor - Wikipedia, the free encyclopedia

Elongation factors are a set of proteins that facilitate the events of translational elongation, the steps in protein synthesis from the formation of the first peptide bond to the formation of the last one. Elongation is the most rapid step in translation: ...

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★リンクテーブル★

リンク元	「ポリペプチド鎖伸長因子」「ペプチド伸長因子」
拡張検索	「peptide elongation factor Tu」「peptide elongation factor 1」「peptide elongation factor 2」「peptide elongation factor G」
関連記事	「elongation」「fact」「factor」

「ポリペプチド鎖伸長因子」

　　[★]

英

polypeptide chain elongation factor

同

ポリペプチド鎖延長因子、エロンゲーション因子、延長因子 elongation factor EF

関

ペプチド伸長因子、peptide elongation factor

「ペプチド伸長因子」

　　[★]

英

peptide elongation factor

関

延長因子、ポリペプチド鎖伸長因子

「peptide elongation factor Tu」

　　[★]

ペプチド伸長因子Tu、伸長因子Tu

関

EF-Tu、elongation factor Tu

「peptide elongation factor 1」

　　[★]

ペプチド伸長因子1、伸長因子1

関

EF-1

「peptide elongation factor 2」

　　[★]

ペプチド伸長因子2、伸長因子2

関

EF-2

「peptide elongation factor G」

　　[★]

ペプチド伸長因子G、伸長因子G

関

EF-G

「elongation」

　　[★]

• n.

• 伸長、延長、伸び、伸長反応、エロンゲーション

関

allongement、elongate、expand、extend、extension、lengthen、lengthening、outgrowth、prolong、prolongation

　 　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter