penicillin G

出典: meddic

ペニシリンG

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/23 01:27:29」(JST)

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英文文献

  • Insights into the relationship between antimicrobial residues and bacterial populations in a hospital-urban wastewater treatment plant system.
  • Varela AR1, André S2, Nunes OC3, Manaia CM4.Author information 1CBQF - Centro de Biotecnologia e Química Fina, Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal; LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.2Agência Portuguesa do Ambiente, I.P., 2610-124 Amadora, Portugal.3LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.4CBQF - Centro de Biotecnologia e Química Fina, Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal. Electronic address: cmanaia@porto.ucp.pt.AbstractThe relationship between antimicrobial residues, antibiotic resistance prevalence and bacterial community composition in hospital effluent and in the receiving wastewater treatment plant was studied. Samples from hospital effluent, raw inflow and final effluent of the receiving wastewater treatment plant were characterized for amoxicillin and ciprofloxacin resistance prevalence, content of heavy metals and antimicrobial residues and bacterial community structure, based on 16S rRNA gene PCR-DGGE analysis. The concentration of fluoroquinolones, arsenic and mercury was in general higher in hospital effluent than in raw inflow, while the opposite was observed for tetracyclines, sulfonamides and penicillin G. The prevalence of ciprofloxacin resistance was significantly higher in hospital effluent than in raw inflow. The concentration of antimicrobial residues was observed to be significantly correlated with the prevalence of antibiotic resistant bacteria and with variations in the bacterial community. Hospital effluent was confirmed as a relevant, although not unique, source of antimicrobial residues and antibiotic resistant bacteria to the wastewater treatment plant. Moreover, given the high loads of antibiotic residues and antibiotic resistant bacteria that may occur in hospital effluents, these wastewater habitats may represent useful models to study and predict the impact of antibiotic residues on bacterial communities.
  • Water research.Water Res.2014 May 1;54:327-36. doi: 10.1016/j.watres.2014.02.003. Epub 2014 Feb 11.
  • The relationship between antimicrobial residues, antibiotic resistance prevalence and bacterial community composition in hospital effluent and in the receiving wastewater treatment plant was studied. Samples from hospital effluent, raw inflow and final effluent of the receiving wastewater treatment
  • PMID 24583524
  • Stability of penicillin G sodium diluted with 0.9% sodium chloride injection or 5% dextrose injection and stored in polyvinyl chloride bag containers and elastomeric pump containers.
  • Hossain MA1, Friciu M, Aubin S, Leclair G.Author information 1Mirza Akram Hossain, B.Sc., is an M.Sc. candidate in pharmaceutics; and Mihaela Friciu, M.Sc., is Research Agent, Université de Montréal, Montréal, Quebec, Canada. Sebastien Aubin, B.Pharm., is Pharmacist, Pharmacie Aubin-Lacasse, Wakefield, Quebec. Grégoire Leclair, B.Pharm., Ph.D., is Pharmacist, Assistant Professor of Pharmaceutics, and member of the Groupe de Recherche Universitaire sur le Médicament, Université de Montréal.AbstractPURPOSE: The stability of penicillin G sodium solutions stored in polyvinyl chloride (PVC) bags or elastomeric pump containers was studied.
  • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.Am J Health Syst Pharm.2014 Apr 15;71(8):669-73. doi: 10.2146/ajhp130440.
  • PURPOSE: The stability of penicillin G sodium solutions stored in polyvinyl chloride (PVC) bags or elastomeric pump containers was studied.METHODS: Test samples were prepared by diluting powdered penicillin G sodium (10 million units/10-mL vial) to solutions of 2,500 or 50,000 units/mL with 0.9% sod
  • PMID 24688042
  • Hydrophilic interaction chromatography-mass spectrometry for anionic metabolic profiling of urine from antibiotic-treated rats.
  • Kok MG1, Swann JR2, Wilson ID3, Somsen GW4, de Jong GJ5.Author information 1Biomolecular Analysis, Department of Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands; Research group Analysis Techniques in Life Sciences, Avans Hogeschool, P.O. Box 90116, 4800 RA Breda, The Netherlands. Electronic address: M.G.M.Kok@uu.nl.2Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, Whiteknights, Reading RG6 6AP, United Kingdom.3Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom.4AIMSS Division of BioAnalytical Chemistry, Department of Chemistry and Pharmaceutical Sciences, VU University, de Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.5Biomolecular Analysis, Department of Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands; Research group Analysis Techniques in Life Sciences, Avans Hogeschool, P.O. Box 90116, 4800 RA Breda, The Netherlands.AbstractHydrophilic interaction chromatography-mass spectrometry (HILIC-MS) was used for anionic metabolic profiling of urine from antibiotic-treated rats to study microbial-host co-metabolism. Rats were treated with the antibiotics penicillin G and streptomycin sulfate for four or eight days and compared to a control group. Urine samples were collected at day zero, four and eight, and analyzed by HILIC-MS. Multivariate data analysis was applied to the urinary metabolic profiles to identify biochemical variation between the treatment groups. Principal component analysis found a clear distinction between those animals receiving antibiotics and the control animals, with twenty-nine discriminatory compounds of which twenty were down-regulated and nine up-regulated upon treatment. In the treatment group receiving antibiotics for four days, a recovery effect was observed for seven compounds after cessation of antibiotic administration. Thirteen discriminatory compounds could be putatively identified based on their accurate mass, including aconitic acid, benzenediol sulfate, ferulic acid sulfate, hippuric acid, indoxyl sulfate, penicillin G, phenol and vanillin 4-sulfate. The rat urine samples had previously been analyzed by capillary electrophoresis (CE) with MS detection and proton nuclear magnetic resonance ((1)H NMR) spectroscopy. Using CE-MS and (1)H NMR spectroscopy seventeen and twenty-five discriminatory compounds were found, respectively. Both hippuric acid and indoxyl sulfate were detected across all three platforms. Additionally, eight compounds were observed with both HILIC-MS and CE-MS. Overall, HILIC-MS appears to be highly complementary to CE-MS and (1)H NMR spectroscopy, identifying additional compounds that discriminate the urine samples from antibiotic-treated and control rats.
  • Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2014 Apr 15;92:98-104. doi: 10.1016/j.jpba.2014.01.008. Epub 2014 Jan 20.
  • Hydrophilic interaction chromatography-mass spectrometry (HILIC-MS) was used for anionic metabolic profiling of urine from antibiotic-treated rats to study microbial-host co-metabolism. Rats were treated with the antibiotics penicillin G and streptomycin sulfate for four or eight days and compared t
  • PMID 24503197

和文文献

  • In vivo efficacy of KRP-109, a novel elastase inhibitor, in a murine model of severe pneumococcal pneumonia.
  • Yamada Koichi,Yanagihara Katsunori,Araki Nobuko,Harada Yosuke,Morinaga Yoshitomo,Izumikawa Koichi,Kakeya Hiroshi,Yamamoto Yoshihiro,Hasegawa Hiroo,Kohno Shigeru,Kamihira Shimeru
  • Pulmonary Pharmacology & Therapeutics 24(6), 660-665, 2011-12
  • … Female mice (CBA/J, aged 5 weeks) were inoculated intranasally with penicillin-susceptible S. pneumoniae (ATCC49619 strain, 2.5 × 10(8) CFU/mouse). …
  • NAID 120003610033
  • Effect of penicillin G on the biliary excretion of cholephilic compounds in rats
  • FUKAMI Masako,TANKA Atsushi,TAKIKAWA Hajime
  • Journal of hepato-biliary-pancreatic sciences 18(5), 684-688, 2011-09-01
  • NAID 10029688455

関連リンク

発見後、医療用として実用化されるまでには10年以上の歳月を要したが、1942年に ベンジルペニシリン(ペニシリンG、PCG)が単 ... フレミングの「ペニシリンの発見」と フローリー等の「ペニシリンの再発見」とそれに続くペニシリンGの実用化は感染症の 臨床治療を ...
ベンジルペニシリン(benzylpenicillin)は、最も質の高い(ゴールド・スタンダード(英語版 ))ペニシリンの一種である。一般的にはペニシリンGとして知られている。ペニシリンGは 胃の塩酸に対して不安定であるため、通常非経口経路で投与される。非経口で投与 ...

関連画像

penicillin g vs v | Hello-Berlin hello  penicillin G, procaine penicillin penicillin g, a common form of penicillinPenicillin-GPenicillin GPenicillin G Injectable - 100 cc.


★リンクテーブル★
リンク元ペニシリンG」「ベンジルペニシリン」「ペニシリン系抗菌薬」「benzathine benzylpenicillin」「benzylpenicillin
拡張検索penicillin-G intermediate resistant Streptococcus pneumonae」「penicillin G-resistant Staphylococcus aureus」「water-soluble penicillin G
関連記事penicillin」「g」「G」「Gd

ペニシリンG」

  [★]

penicillin G, PCG
ベンジルペニシリン benzylpenicillin
注射用ペニシリンGカリウム
ペニシリンG肺炎球菌


特徴

構造

肺炎球菌

  PCGMIC値(μg/ml)
ペニシリン感受性肺炎球菌 PSSP ≦0.06
ペニシリン中等度耐性肺炎球菌 PISP 0.12-1.0
ペニシリン耐性肺炎球菌 PRSP ≧2.0


ベンジルペニシリン」

  [★]

benzylpenicillinpenicillin Gbenzathine benzylpenicillinbenzylpenicillin potassiumbenzylpenicillin benzathine hydrate
benzylpenicillinum
バイシリンバイシリンGピシバニールペニシリンGカリウム
ペニシリンG penicillin G PCGベンジルペニシリンカリウムベンジルペニシリンベンザチンベンジルペニシリンベンザチン水和物
ペニシリン
主としてグラム陽性菌に作用するもの



ペニシリン系抗菌薬」

  [★]

ペニシリン系抗生物質 penicillin antibiotics
抗菌薬βラクタム系抗菌薬ペニシリン


構造

  • 骨格:penam
  • 側鎖のついたβ-ラクタム環を含むチアゾリジン環

ペニシリン系抗菌薬


benzathine benzylpenicillin」

  [★]

ベンジルペニシリンベンザチン

benzathine penicillin Gbenzylpenicillinbenzylpenicillin benzathine hydratebenzylpenicillin potassiumpenicillin G


benzylpenicillin」

  [★]

ベンジルペニシリン

benzathine benzylpenicillinbenzylpenicillin benzathine hydratebenzylpenicillin potassiumpenicillin G
Penicillin G


penicillin-G intermediate resistant Streptococcus pneumonae」

  [★]

PISP
ペニシリンG、Streptococcus pneumonae


penicillin G-resistant Staphylococcus aureus」

  [★] ペニシリンG耐性黄色ブドウ球菌


water-soluble penicillin G」

  [★] 水溶性ペニシリンG


penicillin」

  [★] ペニシリン

WordNet   license wordnet

「any of various antibiotics obtained from Penicillium molds (or produced synthetically) and used in the treatment of various infections and diseases」

PrepTutorEJDIC   license prepejdic

「ペニシリン(坑生物質の一種)」


g」

  [★] グラム

gram

WordNet   license wordnet

「a unit of force equal to the force exerted by gravity; used to indicate the force to which a body is subjected when it is accelerated」
gee, g-force


G」

  [★]

WordNet   license wordnet

「the 7th letter of the Roman alphabet」
g


Gd」

  [★]

ガドリニウム造影MRI




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