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  • Ribavirin Inhibits Human Parainfluenza Virus type 2 Replication in vitro.
  • Kihira S1, Uematsu J, Kawano M, Itoh A, Ohkouchi A, Satoh S, Maeda Y, Sakai K, Yamamoto H, Tsurudome M, O'Brien M, Komada H.
  • Microbiology and immunology.Microbiol Immunol.2014 Aug 25. doi: 10.1111/1348-0421.12192. [Epub ahead of print]
  • The antiviral activities of eight nucleoside analog antiviral drugs (ribavirin, acyclovir, lamivudine, 3'-azido-3'-deoxythymidine, emtricitabine, tenofovir, penciclovir and ganciclovir) against human parainfluenza virus type 2 (hPIV-2) were investigated. Only ribavirin (RBV) inhibited both cell fusi
  • PMID 25154465
  • Single nucleotide polymorphisms of thymidine kinase and DNA polymerase genes in clinical herpes simplex virus type 1 isolates associated with different resistance phenotypes.
  • Schubert A1, Gentner E2, Bohn K3, Schwarz M3, Mertens T1, Sauerbrei A4.
  • Antiviral research.Antiviral Res.2014 Jul;107:16-22. doi: 10.1016/j.antiviral.2014.03.015. Epub 2014 Apr 18.
  • The role of mutations in the thymidine kinase (TK, UL23) and DNA polymerase (pol, UL30) genes of herpes simplex virus (HSV) for development of different resistance phenotypes has to be exactly determined before genotypic resistance testing can be implemented in patient's care. Furthermore, the occur
  • PMID 24747042
  • Testing the sensitivities of noncognate inhibitors to varicella zoster virus thymidine kinase: implications for postherpetic neuralgia therapy with existing agents.
  • Yang L1, Mo X, Yang H, Dai H, Tan F.
  • Journal of molecular modeling.J Mol Model.2014 Jul;20(7):2321. doi: 10.1007/s00894-014-2321-6. Epub 2014 Jun 25.
  • Varicella zoster virus (VZV), a member of the human herpesvirus family, affects peripheral or cranial nerves and can reactivate years after the primary infection. Thymidine kinase (TK) is essential for VZV replication, and its active site is highly conserved in the herpesvirus family. A number of sm
  • PMID 24961898


  • Characterization of DNA Polymerase-Associated Acyclovir-Resistant Herpes Simplex Virus Type 1: Mutations, Sensitivity to Antiviral Compounds, Neurovirulence, and In-Vivo Sensitivity to Treatment
  • Wang Li-Xin,Takayama-Ito Mutsuyo,Kinoshita-Yamaguchi Hitomi [他],Kakiuchi Satsuki,Suzutani Tatsuo,Nakamichi Kazuo,Lim Chang-Kweng,Kurane Ichiro,Saijo Masayuki
  • Japanese Journal of Infectious Diseases 66(5), 404-410, 2013
  • … DNApol-associated ACVr clones showed cross-resistance to foscarnet, penciclovir, and vidarabine but were sensitive or hypersensitive to GCV, brivudin, sorivudine, and spongothymidine. …
  • NAID 130003381717
  • Pharmacology: Pharmacokinetics of penciclovir after oral administration of its prodrug famciclovir to horses
  • Tsujimura Koji,Yamada Masayuki,Nagata Shun-ichi [他]
  • 日本獣醫學会会誌 72(3), 357-361, 2010-03
  • NAID 40017040224
  • Pharmacokinetics of Penciclovir after Oral Administration of its Prodrug Famciclovir to Horses
  • TSUJIMURA Koji,YAMADA Masayuki,NAGATA Shun-ichi,YAMANAKA Takashi,NEMOTO Manabu,KONDO Takashi,KUROSAWA Masahiko,MATSUMURA Tomio
  • Journal of Veterinary Medical Science 72(3), 357-361, 2010
  • … We investigated the pharmacokinetics of penciclovir after oral administration of its prodrug famciclovir to horses. … Following an oral dose of famciclovir at 20 mg/kg, maximum plasma concentrations of penciclovir occurred between 0.75 and 1.5 hr (mean 0.94 ± 0.38 hr) after dosing and were in the range 2.22 to 3.56 μg/ml (mean 2.87 ± 0.61 μg/ml). … The concentrations of penciclovir declined in a biphasic manner after the peak concentration was attained. …
  • NAID 130000134548


... Denavir® (penciclovir cream, 1%) can help them heal when they do reappear. 4 4. Denavir (penciclovir cream, 1%) Prescribing Information. Cranford, NJ: New American Therapeutics, Inc. December 2010. Denavir cream 4 ...
Keep all appointments with your doctor. Penciclovir should only be used on the lips and face. Avoid getting it in your eyes. Keep the infected area clean and dry. Do not let anyone else use your medication. Ask your ...


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