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Paxillin is a signal transduction adaptor protein discovered in 1990 in the laboratory of Keith Burridge.^[1] The C-terminal region of paxillin contains four LIM domains that target paxillin to focal adhesions. It is presumed through a direct association with the cytoplasmic tail of beta-integrin. The N-terminal region of paxillin is rich in protein–protein interaction sites. The proteins that bind to paxillin are diverse and include protein tyrosine kinases, such as Src and focal adhesion kinase (FAK), structural proteins, such as vinculin and actopaxin, and regulators of actin organization, such as COOL/PIX and PKL/GIT. Paxillin is tyrosine-phosphorylated by FAK and Src upon integrin engagement or growth factor stimulation, creating binding sites for the adapter protein Crk.^[2]

References

^ Turner, C. E., Glenney, J. R., Jr. & Burridge, K. Paxillin: a new vinculin-binding protein present in focal adhesions. J Cell Biol 111, 1059–1068 (1990).
^ From the Cell Migration Knowledgebase

External links

MBInfo: Paxillin
Paxillin Info with links in the Cell Migration Gateway
Paxillin at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

Bupleurum chinense polysaccharide inhibit adhesion of human melanoma cells via blocking β1 integrin function.

Tong H1, Jiang G2, Qi D3, Bi J4, Tian D5, Guan X5, Zheng S6, Sun X7.
Carbohydrate polymers.Carbohydr Polym.2017 Jan 20;156:244-252. doi: 10.1016/j.carbpol.2016.09.034. Epub 2016 Sep 13.
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PMID 27842819

Polymer fiber-based models of connective tissue repair and healing.

Lee NM1, Erisken C1, Iskratsch T2, Sheetz M2, Levine WN3, Lu HH4.
Biomaterials.Biomaterials.2017 Jan;112:303-312. doi: 10.1016/j.biomaterials.2016.10.013. Epub 2016 Oct 12.
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PMID 27770633

Uterine focal adhesions are retained at implantation after rat ovarian hyperstimulation.

Lindsay LA1, Dowland SN2, Murphy CR2.
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Controlled ovarian hyperstimulation is an essential component of IVF techniques to ensure proliferation and development of multiple ovarian follicles, but the effects of these hormones on the endometrium are largely unknown. During normal pregnancy in rats, there are significant changes in the basal
PMID 27651522

Japanese Journal

MPC polymer regulates fibrous tissue formation by modulating cell adhesion to the biomaterial surface

ZHANG Ye,KANETAKA Hiroyasu,SANO Yuya,KANO Mitsuhiro,KUDO Tada-aki,SHIMIZU Yoshinaka
Dental materials journal 29(5), 518-528, 2010-09-01
… Furthermore, weaker expressions of paxillin, talin, and ROCK1, but stronger expression of cofilin, were observed in the experimental group. …
NAID 10026669640

MT1-MMP promotes cell growth and ERK activation through c-Src and paxillin in three-dimensional collagen matrix

Takino Takahisa,Tsuge Hisashi,Ozawa Terumasa,Sato Hiroshi
Biochemical and Biophysical Research Communications 396(4), 1042-1047, 2010-06
… These MT1-MMP-mediated signal transductions were paxillin dependent, as knockdown of paxillin reduced cell growth and ERK activation, and co-expression of MT1-MMP with paxillin induced ERK activation. … The results suggest that MT1-MMP contributes to proliferation of cancer cells in the extracellular matrix by activating ERK through c-Src and paxillin. …
NAID 120002224339

LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin

TANAKA Toshiyuki,MORIWAKI Kazumasa,MURATA Shinsuke,MIYASAKA Masayuki
Cancer science 101(2), 363-368, 2010-02-10
NAID 10026587701

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Paxillin
	; Rendering based on PDB 1KKY.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1KKY, 1KL0, 1OW6, 1OW7, 1OW8, 2K2R, 2O9V, 2VZD, 2VZG, 2VZI, 3GM1, 3PY7, 3RQE, 3RQF, 3RQG, 3U3C, 3U3F, 4EDN
Identifiers
Symbols	PXN ; FLJ16691
External IDs	OMIM: 602505 MGI: 108295 HomoloGene: 37697 ChEMBL: 5715 GeneCards: PXN Gene
Gene ontology
Molecular function	• integrin binding; • protein binding; • beta-catenin binding; • zinc ion binding; • vinculin binding; • protein kinase binding; • BH4 domain binding;
Cellular component	• nucleus; • nucleolus; • cytoplasm; • microtubule associated complex; • plasma membrane; • focal adhesion; • cell cortex; • lamellipodium;
Biological process	• activation of MAPK activity; • cellular component movement; • muscle contraction; • cytoskeleton organization; • cell adhesion; • signal transduction; • signal complex assembly; • epidermal growth factor receptor signaling pathway; • integrin-mediated signaling pathway; • peptidyl-tyrosine phosphorylation; • lamellipodium assembly; • cell junction assembly; • cellular response to reactive oxygen species; • focal adhesion assembly; • branching morphogenesis of an epithelial tube; • growth hormone receptor signaling pathway;
	Sources: Amigo / QuickGO
Orthologs
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英: paxillin

細胞-マトリックス接着関連タンパク質

[1] Turner, C. E., Glenney, J. R., Jr. & Burridge, K. Paxillin: a new vinculin-binding protein present in focal adhesions. J Cell Biol 111, 1059–1068 (1990).

[2] From the Cell Migration Knowledgebase

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paxillin