parathyroid hormone receptor

• 副甲状腺ホルモン受容体、上皮小体ホルモン受容体、副甲状腺ホルモンレセプター、上皮小体ホルモンレセプター

関

type 1 parathyroid hormone receptor

WordNet

1. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
2. the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion

PrepTutorEJDIC

1. =sense organ / 受信装置
2. ホルモン
3. 副甲状腺の,上皮小体の

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/24 04:37:08」(JST)

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[Wiki en表示]

parathyroid hormone 1 receptor
Identifiers
Symbol	PTH1R
Alt. symbols	PTHR, PFE
Entrez	5745
HUGO	9608
OMIM	168468
RefSeq	NM_000316
UniProt	Q03431
Other data
Locus	Chr. 3 p22-p21.1

parathyroid hormone 2 receptor
Identifiers
Symbol	PTH2R
Entrez	5746
HUGO	9609
OMIM	601469
RefSeq	NM_005048
UniProt	P49190
Other data
Locus	Chr. 2 q33

There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.

• parathyroid hormone 1 receptor (PTH1R) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.
• parathyroid hormone 2 receptor (PTH2R) is expressed primarily in the central nervous system, pancreas, testis, and placenta.

References

External links

• Parathyroid Hormone Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
• "Parathyroid Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

UpToDate Contents

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• 1. 副甲状腺ホルモンの分泌および作用 parathyroid hormone secretion and action
• 2. カルシウムおよびリン酸バランスの調節 regulation of calcium and phosphate balance
• 3. 閉経後の女性における骨粗鬆症のマネージメントの概要 overview of the management of osteoporosis in postmenopausal women
• 4. 副甲状腺ホルモン測定およびその臨床応用 parathyroid hormone assays and their clinical use
• 5. 原発性副甲状腺機能亢進症：マネージメント primary hyperparathyroidism management

English Journal

• Drug-releasing nano-engineered titanium implants: therapeutic efficacy in 3D cell culture model, controlled release and stability.

• Gulati K1, Kogawa M2, Prideaux M2, Findlay DM2, Atkins GJ3, Losic D4.
• Materials science & engineering. C, Materials for biological applications.Mater Sci Eng C Mater Biol Appl.2016 Dec 1;69:831-40. doi: 10.1016/j.msec.2016.07.047. Epub 2016 Jul 21.
• There is an ongoing demand for new approaches for treating localized bone pathologies. Here we propose a new strategy for treatment of such conditions, via local delivery of hormones/drugs to the trauma site using drug releasing nano-engineered implants. The proposed implants were prepared in the fo
• PMID 27612777

• Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signaling.

• Zindel D1,2,3, Engel S1, Bottrill AR4, Pin JP2,3, Prézeau L2,3, Tobin AB5, Bünemann M1, Krasel C1, Butcher AJ6.
• The Biochemical journal.Biochem J.2016 Nov 15;473(22):4173-4192. Epub 2016 Sep 13.
• The parathyroid hormone receptor 1 (PTH1R) is a member of family B of G-protein-coupled receptors (GPCRs), predominantly expressed in bone and kidney where it modulates extracellular Ca2+ homeostasis and bone turnover. It is well established that phosphorylation of GPCRs constitutes a key event in r
• PMID 27623777

• Fgf23 and parathyroid hormone signaling interact in kidney and bone.

• Andrukhova O1, Streicher C1, Zeitz U1, Erben RG2.
• Molecular and cellular endocrinology.Mol Cell Endocrinol.2016 Nov 15;436:224-39. doi: 10.1016/j.mce.2016.07.035. Epub 2016 Aug 4.
• Fibroblast growth factor-23 (FGF23) is a bone-derived hormone, suppressing renal phosphate reabsorption and vitamin D hormone synthesis in proximal tubules, and stimulating calcium reabsorption in distal tubules of the kidney. Here, we analyzed the long term sequelae of deficient Fgf23 signaling on
• PMID 27498418

Japanese Journal

• Cartilaginous repair of full-thickness articular cartilage defects is induced by the intermittent activation of PTH/PTHrP signaling.

• Kudo Satoshi,Mizuta Hiroshi,Takagi Katsumasa,Hiraki Yuji
• Osteoarthritis and cartilage 19(7), 886-894, 2011-07
• … Objective：We studied the effects of the transient activation of parathyroid hormone (PTH)/PTH-related peptide (PTHrP) signaling during the repair of 5-mm-diameter full-thickness defects of articular cartilage in the rabbit. … Double immunostaining analysis was also performed for the PTH/PTHrP receptor and proliferating cell nuclear antigen (PCNA) in the regenerating tissues. …
• NAID 120003255718

• Parathyroid hormone 1 (1-34) acts on the scales and involves calcium metabolism in goldfish

• Suzuki Nobuo,Danks Janine A.,Maruyama Yusuke,Ikegame Mika,Sasayama Yuichi,Hattori Atsuhiko,Nakamura Masahisa,Tabata Makoto J.,Yamamoto Toshio,Furuya Ryo,Saijoh Kiyofumi,Mishima Hiroyuki,Srivastav Ajai K.,Furusawa Yukihiro,Kondo Takashi,Tabuchi Yoshiaki,Takasaki Ichiro,Chowdhury Vishwajit S.,Hayakawa Kazuichi,Martin T. John
• Bone 48(5), 1186-1193, 2011-05-01
• … The effect of fugu parathyroid hormone 1 (fugu PTH1) on osteoblasts and osteoclasts in teleosts was examined with an assay system using teleost scale and the following markers: alkaline phosphatase (ALP) for osteoblasts and tartrate-resistant acid phosphatase (TRAP) for osteoclasts. …
• NAID 120003020733

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★リンクテーブル★

リンク元	「副甲状腺ホルモン受容体」「上皮小体ホルモン受容体」「上皮小体ホルモンレセプター」「副甲状腺ホルモンレセプター」
拡張検索	「type 1 parathyroid hormone receptor」「type 2 parathyroid hormone receptor」
関連記事	「parathyroid」「hormone receptor」「parathyroid hormone」

「副甲状腺ホルモン受容体」

　　[★]

英

parathyroid hormone receptor

関

副甲状腺ホルモンレセプター、上皮小体ホルモンレセプター、上皮小体ホルモン受容体、I型副甲状腺ホルモン受容体

「上皮小体ホルモン受容体」

　　[★]

英

parathyroid hormone receptor

関

副甲状腺ホルモン受容体、副甲状腺ホルモンレセプター、上皮小体ホルモンレセプター

「上皮小体ホルモンレセプター」

　　[★]

英

parathyroid hormone receptor

関

副甲状腺ホルモン受容体、副甲状腺ホルモンレセプター、上皮小体ホルモン受容体

「副甲状腺ホルモンレセプター」

　　[★]

英

parathyroid hormone receptor

関

副甲状腺ホルモン受容体、上皮小体ホルモンレセプター、上皮小体ホルモン受容体

「type 1 parathyroid hormone receptor」

　　[★]

• I型副甲状腺ホルモン受容体

関

parathyroid hormone receptor

「type 2 parathyroid hormone receptor」

　　[★]

• II型副甲状腺ホルモン受容体

「parathyroid」

　　[★]

• adj.

• 副甲状腺の、上皮小体の

関

parathyroid gland

「hormone receptor」

　　[★]

• ホルモン受容体、ホルモンレセプター

「parathyroid hormone」

　　[★] 副甲状腺ホルモン PTH