WordNet

relating to or occurring in a term or fixed period of time; "terminal examinations"; "terminal payments"
a contact on an electrical device (such as a battery) at which electric current enters or leaves (同)pole
station where transport vehicles load or unload passengers or goods (同)terminus, depot
electronic equipment consisting of a device providing access to a computer; has a keyboard and display
being or situated at an end; "the endmost pillar"; "terminal buds on a branch"; "a terminal station"; "the terminal syllable"
causing or ending in or approaching death; "a terminal patient"; "terminal cancer"
of or relating to or situated at the ends of a delivery route; "freight pickup is a terminal service"; "terminal charges"
the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion

PrepTutorEJDIC

『終りの』,末端の / 毎期の,定期の;学期末の / 『死に至る』, / 末端 / (電池の)端子 / (町の中心に近い)空港バス発着場;(一般に,鉄道・バスの)終点,終着駅
carbonの化学記号
ホルモン
副甲状腺の,上皮小体の
cesiumの化学記号

UpToDate Contents

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1. 副甲状腺ホルモン測定およびその臨床応用 parathyroid hormone assays and their clinical use
2. 副甲状腺ホルモンの分泌および作用 parathyroid hormone secretion and action
3. 骨粗鬆症に対する副甲状腺ホルモン療法 parathyroid hormone therapy for osteoporosis
4. 術中の副甲状腺ホルモンモニタリング intraoperative parathyroid hormone monitoring
5. 高カルシウム血症への診断的アプローチ diagnostic approach to hypercalcemia

English Journal

Identification of carboxyl-terminal peptide fragments of parathyroid hormone in human plasma at low-picomolar levels by mass spectrometry.

Zhang CX, Weber BV, Thammavong J, Grover TA, Wells DS.Author information NPS Pharmaceuticals, 383 Colorow Drive, Salt lake City, Utah 84108, USA. czhang@npsp.comAbstractFor decades, researchers have tried to identify the primary structures of circulating carboxyl-terminal parathyroid hormone (C-PTH) peptide fragments that may be present at only picomolar levels in human plasma. Although immunoassays and radiosequencing techniques have provided valuable fragment characterizations, no analysis has successfully determined their exact primary structures. In this work, for the first time, four human C-PTH peptide fragments, hPTH(34-84), hPTH(37-84), hPTH(38-84), and hPTH(45-84), have been identified from human plasma using MS-based methods. C-PTH peptide fragments were isolated from plasma samples by immunoaffinity extraction. The eluate was analyzed by capillary LC fractionation followed by MALDI-TOF-MS or by on-line coupling of nano-LC with ESI-TOF-MS. Both the MALDI- and the ESI-based approaches were capable of detecting C-PTH peptide fragments in human plasma at <10 pmol/L. The MALDI-TOF approach was effective in preliminary searches for C-PTH peptide fragments, but the use of high laser power limited the resolution necessary for accurate C-PTH peptide identification. The high mass resolution (10,000) and accuracy (10 ppm) attained by the ESI-TOF approach enabled unambiguous identification of these peptides. The four C-PTH peptide fragments identified in plasma samples from patients with chronic renal insufficiency were also found in the plasma of healthy women receiving recombinant human PTH either by subcutaneous injection or by intravenous infusion. This newly developed analytical capability should greatly enhance the understanding of PTH metabolism and parathyroid gland function.
Analytical chemistry.Anal Chem.2006 Mar 1;78(5):1636-43.
For decades, researchers have tried to identify the primary structures of circulating carboxyl-terminal parathyroid hormone (C-PTH) peptide fragments that may be present at only picomolar levels in human plasma. Although immunoassays and radiosequencing techniques have provided valuable fragment cha
PMID 16503617

hPTH-fragments (53-84) and (28-48) antagonize the stimulation of calcium release and repression of alkaline phosphatase activity by hPTH-(1-34) in vitro.

Duvos C, Scutt A, Mayer H.Author information German Research Centre for Biotechnology, Department of Gene Regulation and Differentiation, Mascheroderwag 1, D-38124 Braunschweig, Germany.AbstractDifferent C-terminal fragments of parathyroid hormone (PTH)-(1-84) in blood participate in the regulation of calcium homeostasis by PTH-(1-84), and an antagonizing effect for the large carboxyl-terminal parathyroid hormone (C-PTH)-fragment (7-84) on calcium release has been described in vivo and in vitro. In this study the smaller C-PTH-fragment (53-84) and mid-regional PTH fragment (28-48), which represent discrete areas of activity in the PTH-(7-84) molecule, were assayed for their effects on calcium release and alkaline phosphatase (ALP) activity in a chick bone organ culture system. Neither PTH-(28-48) nor PTH-(53-84) had any effect on calcium release into the medium and both fragments stimulated ALP activity in the bone tissue, suggesting that the cAMP/PKA signalling pathway was not affected by these fragments. However they suppressed the calcium release induced by PTH-(1-34) and attenuated the down regulation of ALP activity caused by PTH-(1-34), suggesting that the effect on the cAMP/PKA signalling pathway may be indirectly. In conclusion, the study shows that the PTH-fragments (53-84) and (28-48) antagonize the PTH-(1-34) induced effects on calcium release and inhibition of ALP activity in a chick bone organ culture system.
FEBS letters.FEBS Lett.2006 Feb 20;580(5):1509-14. Epub 2006 Jan 31.
Different C-terminal fragments of parathyroid hormone (PTH)-(1-84) in blood participate in the regulation of calcium homeostasis by PTH-(1-84), and an antagonizing effect for the large carboxyl-terminal parathyroid hormone (C-PTH)-fragment (7-84) on calcium release has been described in vivo and in
PMID 16466718

Carboxyl-terminal parathyroid hormone fragments: role in parathyroid hormone physiopathology.

D'Amour P, Brossard JH.Author information Centre de recherche, Centre hospitalier de l'Université de Montréal, Hôpital Saint-Luc et Département de médecine, Université de Montréal, Montréal, Québec, Canada. rechcalcium.chum@ssss.gouv.qc.caAbstractPURPOSE OF REVIEW: Carboxyl-terminal parathyroid hormone (C-PTH) fragments constitute 80% of circulating PTH. Since the first 34 amino acids of the PTH structure are sufficient to explain PTH classical biological effects on the type I PTH/PTHrP receptor and since C-PTH fragments do not bind to this receptor, they have long been considered inactive. Recent data suggest the existence of a C-PTH receptor through which C-PTH fragments exert biological effects opposite to those of human PTH(1-84) on the type I PTH/PTHrP receptor. This is why a lot of attention has been paid to these fragments recently.
Current opinion in nephrology and hypertension.Curr Opin Nephrol Hypertens.2005 Jul;14(4):330-6.
PURPOSE OF REVIEW: Carboxyl-terminal parathyroid hormone (C-PTH) fragments constitute 80% of circulating PTH. Since the first 34 amino acids of the PTH structure are sufficient to explain PTH classical biological effects on the type I PTH/PTHrP receptor and since C-PTH fragments do not bind to this
PMID 15931000

Japanese Journal

わが国の慢性透析療法の現況(1997年12月31日現在)

日本透析医学会統計調査委員会,前田憲志
日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 32(1), 1-17, 1999-01-28
… また, 透析導入症例における原疾患の割合は慢性糸球体腎炎が36.6%と昨年よりもさらに減少し, 糖尿病性腎症は33.9%とさらに増加した.1997年度は新たに高感度副甲状腺ホルモン (HS-PTH), 副甲状腺ホルモンC末端 (C-PTH), アルカリフォスファターゼ (ALP), 透析前血清カルシウム濃度, ビタミンD製剤の投与の有無, そして副甲状腺摘除術の既往の有無などについて調査された. …
NAID 10004921018

透析患者における副甲状腺腫切除術の心臓に及ぼす影響

高見沢重隆,太田真,佐藤成明,宇都宮正範,小野益照,斎藤広重,川口良人,酒井紀
日本透析医学会雑誌 27(8), 1133-1138, 1994
… 左室収縮末期径 (LVDs), 心筋重量係数 (LVMI), 心係数 (CI), 左室駆出率 (EF), 左室平均円周短縮速度 (mVcf), relative wall thickness (RWT) を計測し, 同時に心拍数 (HR), 収縮期血圧 (sBP), 拡張期血圧 (dBP), 心胸比 (CTR), またHt, c-PTH, Ca, Pも測定した.対照群においてはすべての指標で有意な変化を示さなかったのに対し, PTX施行例では1年後にEF, mVcf, RWTは変化しなかったが, IVS, PW, LVDd, LVMI, CIの低下を認めた.二次性副甲状腺機能亢進症例に …
NAID 130003874628

A case of non-Hodgkin's lymphoma associated with hypercalcemia.

Suemaru Shuso,Kageyama Jingo,Ota Zenske,Ohnoshi Taisuke,Sakamoto Kenji,Kamura Junta
Acta Medica Okayama 45(1), 1991-02
… The serum level of immunoreactive parathyroid hormone C-terminal (PTH-C) was normal. …
NAID 120002311705