UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

The role of caldesmon and its phosphorylation by ERK on the binding force of unphosphorylated myosin to actin.

Roman HN1, Zitouni NB2, Kachmar L2, Benedetti A3, Sobieszek A4, Lauzon AM5.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Nov;1840(11):3218-25. doi: 10.1016/j.bbagen.2014.07.024. Epub 2014 Aug 7.
BACKGROUND: Studies conducted at the whole muscle level have shown that smooth muscle can maintain tension with low Adenosine triphosphate (ATP) consumption. Whereas it is generally accepted that this property (latch-state) is a consequence of the dephosphorylation of myosin during its attachment to
PMID 25108062

Yonkenafil: A novel phosphodiesterase type 5 inhibitor induces neuronal network potentiation by a cGMP-dependent Nogo-R axis in acute experimental stroke.

Chen X1, Wang N1, Liu Y1, Liu Y1, Zhang T1, Zhu L1, Wang Y2, Wu C3, Yang J4.
Experimental neurology.Exp Neurol.2014 Nov;261C:267-277. doi: 10.1016/j.expneurol.2014.07.007. Epub 2014 Jul 23.
Yonkenafil is a novel phosphodiesterase type 5 (PDE5) inhibitor. Here we evaluated the effect of yonkenafil on ischemic injury and its possible mechanism of action. Male Sprague-Dawley rats underwent middle cerebral artery occlusion, followed by intraperitoneal or intravenous treatment with yonkenaf
PMID 25064698

TrkB kinase activity is critical for recovery of respiratory function after cervical spinal cord hemisection.

Mantilla CB1, Greising SM2, Stowe JM2, Zhan WZ2, Sieck GC3.
Experimental neurology.Exp Neurol.2014 Nov;261C:190-195. doi: 10.1016/j.expneurol.2014.05.027. Epub 2014 Jun 5.
Neuroplasticity following spinal cord injury contributes to spontaneous recovery over time. Recent studies highlight the important role of brain-derived neurotrophic factor (BDNF) signaling via the high-affinity tropomyosin-related kinase (Trk) receptor subtype B (TrkB) in recovery of rhythmic diaph
PMID 24910201

P1-16-3 Paramyosinを原因抗原と考えたアニサキスアレルギーによる蕁麻疹の1例(P1-16 食物アレルギー3,ポスターセッション,第23回日本アレルギー学会春季臨床大会)

Intranasal administration of Schistosoma japonicum paramyosin induced robust long-lasting systemic and local antibody as well as delayed-type hypersensitivity responses, but failed to confer protection in a mouse infection model

松野 [アキラ]
比較生理生化学 27(2), 54-61, 2010-04-20
　ある種の平滑筋は１度収縮すると，その後ほとんどエネルギー消費をしないで収縮したままの状態を保つことができる特殊な筋収縮をする。このような収縮はキャッチ収縮と呼ばれ，キャッチ収縮を引き起こす機構をキャッチ機構と呼ぶ。キャッチ機構の研究には色々なアプローチが試みられており，現在では，生化学的および分子生物学的手法でキャッチ状態を解除する機構までもが明らかにされている。少し過去にさかのぼると，キャッチ …
NAID 10029409147

リンク元