English Journal

Platelets and platelet-derived factor Va confer hemostatic competence in complete factor V deficiency.

Bouchard BA1, Chapin J1, Brummel-Ziedins KE1, Durda P2, Key NS3, Tracy PB1.
Blood.Blood.2015 Jun 4;125(23):3647-50. doi: 10.1182/blood-2014-07-589580. Epub 2015 Apr 20.
Whole genome sequencing of an individual completely devoid of plasma- and platelet-derived factor V (FV) identified 167 variants in his F5 gene including previously identified and damaging missense mutations at rs6027 and Leu90Ser. Because the administration of fresh frozen plasma (FFP) prevents gas
PMID 25896652

Recurrent hemoperitoneum secondary to haemorrhage from the corpus luteum unmasks factor V deficiency.

Badyal RK1, Jain K, Mandrelle K, John MJ, Kakkar N, Bose SK, Kumar N, Ahluwalia J.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.Blood Coagul Fibrinolysis.2015 Apr 17. [Epub ahead of print]
Factor V deficiency is a rare autosomal recessive coagulation disorder. We report a case with inherited factor V deficiency presenting as life-threatening recurrent hemoperitoneum, following bleeding from ruptured corpus haemorrhagicum. Prolonged prothrombin and activated partial thromboplastin time
PMID 25886835

Acquired factor V deficiency in myeloproliferative neoplasms: a Mayo Clinic series of 33 patients.

Ashrani AA1, Tefferi A, Pruthi RK, Pardanani A.
British journal of haematology.Br J Haematol.2015 Apr 8. doi: 10.1111/bjh.13438. [Epub ahead of print]
PMID 25854415

Japanese Journal

坂田好史,三島秀雄,山口和哉,平林直樹
日本消化器外科学会雑誌 36(11), 1626-1629, 2003-11-01
症例は71歳の女性で.1999年4月頃から近医で貧血症と便潜血陽性を指摘され当科へ紹介された.両親がいとこ同士の結婚であった.注腸造影検査で肝彎曲部に陰影欠損像を認めた.大腸内視鏡検査では肝彎曲節に1型腫瘍を認めた.入院時検査所見ではプロトロンビン時間(PT)22.8秒(23.5%),活性化部分トロンボプラステン時間(APTT)58.1秒と延長していた.出血時間は2分,ヘパプラスチンテストは98. …
NAID 110001294749

坂田好史,三島秀雄,山口和哉,平林直樹
日本消化器外科学会雑誌 36(11), 1626-1629, 2003
… We found the patient had congenital factor V deficiency (parahemophilia), so we transfused 6 units of fresh frozen plasma (FFP) preoperatively to improve PT and APTT. …
NAID 130004343876