肺吸虫症
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/18 06:50:17」(JST)
[Wiki en表示]
| Paragonimiasis |
| Classification and external resources |
| ICD-10 |
B66.4 |
| DiseasesDB |
30756 |
| eMedicine |
ped/1729 |
Paragonimiasis is a food-borne parasitic infection caused by the lung fluke, most commonly Paragonimus westermani. It infects an estimated 22 million people worldwide.[1] It is particularly common in East Asia. More than 30 species of trematodes (flukes) of the genus Paragonimus have been reported; among the more than 10 species reported to infect humans, the most common is P. westermani, the oriental lung fluke.[2]
|
Contents
- 1 Life cycle
- 2 Geographic distribution
- 3 Symptoms and diagnosis
- 4 Treatment
- 5 References
|
Life cycle
The U.S. Centers for Disease Control and Prevention (CDC) has a detailed description and an explanatory image of the Paragonimus lifecycle: [1]
- "The eggs of the paragonimiasis are excreted unembryonated in the sputum, or alternately they are swallowed and passed with stool. In the external environment, the eggs become embryonated, and miracidia hatch and seek the first intermediate host, a snail, and penetrate its soft tissues. Miracidia go through several developmental stages inside the snail: sporocysts and rediae, with the latter giving rise to many cercariae, which emerge from the snail. The cercariae invade the second intermediate host, a crustacean such as a crab or crayfish, where they encyst and become metacercariae. This is the infective stage for the mammalian host. Human infection with P. westermani occurs by eating inadequately cooked or pickled crab or crayfish that harbor metacercariae of the parasite. The metacercariae excyst in the duodenum, penetrate through the intestinal wall into the peritoneal cavity, then through the abdominal wall and diaphragm into the lungs, where they become encapsulated and develop into adults (7.5 to 12 mm by 4 to 6 mm). The worms can also reach other organs and tissues, such as the brain and striated muscles, respectively. However, when this takes place completion of the life cycles is not achieved, because the eggs laid cannot exit these sites. Time from infection to oviposition is 65 to 90 days. Infections may persist for 20 years in humans. Animals such as pigs, dogs, and a variety of feline species can also harbor P. westermani."[2]
Geographic distribution
Species of Paragonimus are widely distributed in Asia, Africa, and North and South America. Paragonimus westermani is found in southeast Asia and Japan, while Paragonimus kellicotti is endemic to North America.[2]
Symptoms and diagnosis
- "The acute phase (invasion and migration) may be marked by diarrhea, abdominal pain, fever, cough, urticaria, hepatosplenomegaly, pulmonary abnormalities, and eosinophilia. During the chronic phase, pulmonary manifestations include cough, expectoration of discolored sputum, hemoptysis, and chest radiographic abnormalities. Extrapulmonary locations of the adult worms result in more severe manifestations, especially when the brain is involved."[3] "Diagnosis is based on microscopic demonstration of eggs in stool or sputum, but these are not present until 2 to 3 months after infection. (Eggs are also occasionally encountered in effusion fluid or biopsy material.) Concentration techniques may be necessary in patients with light infections. Biopsy may allow diagnostic confirmation and species identification when an adult or developing fluke is recovered."[3]
Paragonimiasis can commonly be misdiagnosed as Tuberculosis.[4]
Treatment
The drug of choice to treat paragonimiasis is Praziquantel, although Bithionol may also be used.[3] Both are anti-parasitics.
References
- ^ M.R. Haswell-Elkins, D.B. Elkins, "Lung and liver flukes," in: Leslie Collier, Albert Balows, Max Sussman (editors), Topley and Wilson's Microbiology and Microbial Infections, Vol. 5. 9th Ed. New York: Oxford University Press; 1998. pp. 507-20. ISBN 0340663200
- ^ a b c "Paragonimiasis", 13 October 2010, Center for Global Health, U.S. Centers for Disease Control and Prevention (CDC). Accessed 6 September 2012.
- ^ a b c "Paragonimiasis, Clinical Features", 13 October 2010, CDC. Accessed 6 September 2012.
- ^ Michael A. Lane, et al. "Human Paragonimiasis in North America following Ingestion of Raw Crayfish" in: Clinical Infectious Diseases 49.6 (2009): e55-e61, EBSCO. 13 Oct. 2010.
|
Infectious diseases · Parasitic disease: helminthiases (B65–B83, 120–129)
|
|
Flatworm/
platyhelminth |
|
Fluke/trematode
(Trematode infection)
|
|
Blood fluke
|
Schistosoma mansoni/japonicum/mekongi/haematobium (Schistosomiasis) · Trichobilharzia regenti (Swimmer's itch)
|
|
|
Liver fluke
|
Clonorchis sinensis (Clonorchiasis) · Dicrocoelium dendriticum/Dicrocoelium hospes (Dicrocoeliasis) · Fasciola hepatica/gigantica (Fascioliasis) · Opisthorchis viverrini/Opisthorchis felineus (Opisthorchiasis)
|
|
|
Lung fluke
|
Paragonimus westermani (Paragonimiasis)
|
|
|
Intestinal fluke
|
Fasciolopsis buski (Fasciolopsiasis) · Metagonimus yokagawai (Metagonimiasis) · Heterophyes heterophyes (Heterophyiasis)
|
|
|
|
Cestoda
(Tapeworm infection)
|
|
Cyclophyllidea
|
Echinococcus granulosus/Echinococcus multilocularis (Echinococcosis) · Taenia saginata (beef)/Taenia asiatica/Taenia solium (pork) (Taeniasis/Cysticercosis) · Hymenolepis nana/Hymenolepis diminuta (Hymenolepiasis)
|
|
|
Pseudophyllidea
|
Diphyllobothrium latum (Diphyllobothriasis) · Spirometra erinaceieuropaei (Sparganosis) · Diphyllobothrium mansonoides (Sparganosis)
|
|
|
|
Roundworm/
nematode
(Nematode
infection) |
|
Secernentea
|
|
Spirurida
|
|
Camallanina
|
Dracunculus medinensis (Dracunculiasis)
|
|
|
Spirurina
|
|
Filarioidea
(Filariasis)
|
Onchocerca volvulus (Onchocerciasis) · Loa loa (Loa loa filariasis) · Mansonella (Mansonelliasis) · Dirofilaria repens (Dirofilariasis)
Wuchereria bancrofti · Brugia malayi · Brugia timori
|
|
|
Thelazioidea
|
Gnathostoma spinigerum/Gnathostoma hispidum (Gnathostomiasis) · Thelazia (Thelaziasis)
|
|
|
Spiruroidea
|
Gongylonema
|
|
|
|
|
Strongylida
(hookworm)
|
Ancylostoma duodenale/Ancylostoma braziliense (Ancylostomiasis, Cutaneous larva migrans) · Necator americanus (Necatoriasis) · Angiostrongylus cantonensis (Angiostrongyliasis) · Metastrongylus (Metastrongylosis)
|
|
|
Ascaridida
|
Ascaris lumbricoides (Ascariasis) · Anisakis (Anisakiasis) · Toxocara canis/Toxocara cati (Visceral larva migrans/Toxocariasis) · Baylisascaris · Dioctophyme renale (Dioctophymosis)
|
|
|
Rhabditida
|
Strongyloides stercoralis (Strongyloidiasis) · Trichostrongylus spp. (Trichostrongyliasis)
|
|
|
Oxyurida
|
Enterobius vermicularis (Enterobiasis · Pinworm)
|
|
|
|
Adenophorea
|
Trichinella spiralis (Trichinosis) · Trichuris trichiura (Trichuriasis · Whipworm) · Capillaria philippinensis (Intestinal capillariasis) · Capillaria hepatica
|
|
|
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Cerebral paragonimiasis: A retrospective analysis of 89 cases.
- Chen J, Chen Z, Lin J, Zhu G, Meng H, Cui G, Wu N, Hu R, Pan J, Zou Y, Feng H.SourceDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038 People's Republic of China.
- Clinical neurology and neurosurgery.Clin Neurol Neurosurg.2013 May;115(5):546-51. doi: 10.1016/j.clineuro.2012.06.025. Epub 2012 Jul 13.
- PURPOSE: We reviewed the clinical and follow-up data of 89 cases with cerebral paragonimiasis and summarized the disease characteristics, diagnostic strategies and treatment experience, with an expectation of establishing standard diagnosis and treatment for cerebral paragonimiasis.METHODS: A total
- PMID 22795301
- Current status of lung fluke metacercarial infection in freshwater crabs in the kawane area of shizuoka prefecture, Japan.
- Sugiyama H, Shibata K, Morishima Y, Muto M, Yamasaki H, Kawakami Y.SourceDepartment of Parasitology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan.
- The Journal of veterinary medical science / the Japanese Society of Veterinary Science.J Vet Med Sci.2013 Apr 1;75(3):249-53. Epub 2012 Oct 18.
- Feline cases of lung fluke infection were recently reported in the upper basin of the Oi River in Shizuoka Prefecture. The causative species of these cases were not identified, although a field survey conducted about 40 years ago in this area demonstrated the prevalence of Paragonimus miyazakii meta
- PMID 23076034
- Detection of multiple species of human Paragonimus from Mexico using morphological data and molecular barcodes.
- López-Caballero J, Oceguera-Figueroa A, León-Règagnon V.SourceLaboratorio de Helmintología, Instituto de Biología, Universidad Nacional Autónoma de México, Mexico, D.F. 04510, Mexico; Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico, D.F. 04510, México.
- Molecular ecology resources.Mol Ecol Resour.2013 Mar 26. doi: 10.1111/1755-0998.12093. [Epub ahead of print]
- Paragonimus mexicanus is the causal agent of human paragonimiasis in several countries of the Americas. It is considered to be the only species of the genus present in Mexico, where it is responsible for human infection. Through the investigation of P. mexicanus specimens from several places through
- PMID 23530893
Japanese Journal
- シカ生肉が感染源と考えられたウエステルマン肺吸虫症の1例
- 大内 政嗣,井上 修平,尾崎 良智,藤田 琢也,上田 桂子,花岡 淳
- 日本呼吸器外科学会雑誌 28(2), 170-176, 2014
- シカ生肉が感染源と考えられたウエステルマン肺吸虫症の1例を経験したので報告する．症例は49歳，男性．腹部不快感に続く気胸，胸水のため当科紹介となった．発症2週間前にシカ生肉の摂食歴があり，末梢血と胸水の好酸球増多から肺吸虫症を疑った．胸水が高度に混濁しており，膿胸を合併した自然気胸の可能性を否定できず，胸腔鏡下手術を施行した．横隔膜と壁側胸膜に多数の膿苔が認められ，下葉の臓側胸膜にも膿苔が存在して …
- NAID 130003394011
- 症例 鑑別が困難であったズビニ鉤虫症の重複感染した肺吸虫症の1例
- 嶺崎 祥平,平間 崇,塩野 文子 [他]
- 感染症学雑誌 = The journal of Japanese the Association for Infectious Diseases 87(6), 756-760, 2013-11
- NAID 40019903647
- 症例 喀痰の鏡検で診断されたウエステルマン肺吸虫症の1例
- 田中 希宇人,猶木 克彦,扇野 圭子 [他]
- 日本呼吸器学会誌 = Annals of the Japanese Respiratory Society 2(5), 633-636, 2013-09-10
- NAID 40019815228
Related Links
- Paragonimiasis is a food-borne parasitic infection caused by the lung fluke, most commonly Paragonimus westermani. It infects an estimated 22 million people worldwide. It is particularly common in East Asia. More than 30 species of ...
- Paragonimiasis. Introduction. Paragonimiasis, or lung fluke disease, is caused by infection with a number of species of trematodes belonging to the genus Paragonimus. The most common are: P. westermani, P. heterotremus and P.
Related Pictures
★リンクテーブル★
[★]
肺吸虫、肺吸虫属、パラゴニムス属、Paragonimus属
- 同
- paragonimiasis
[★]
- 英
- paragonimiasis, lung fluke disease
- 同
- 肺ジストマ症
[★]
ウェステルマン肺吸虫症