WordNet

any of a group of animal viruses associated with or causing papillomas or polyomas

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/23 08:44:47」(JST)

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A Papovavirus is any member of the former virus family of Papovaviridae.^[1] They are mainly associated with various neoplasms in mammals.^[1] The family of Papovaviridae is no longer used in recent taxonomy, but is split into the Papillomaviridae and the Polyomaviridae.^[2]

The name derives from three abbreviations: Pa for papillomavirus, Po for polyomavirus, and Va for "vacuolating" (simian vacuolating virus 40 or SV40, which is now known to be part of the polyomavirus genus).

Papovaviruses are DNA viruses containing double-stranded DNA, are icosahedral in shape, and do not have a lipoprotein envelope.

They are commonly found in humans and other species, mostly mammals. The one that most often causes disease in humans is the human papillomavirus.

References

^ ^a ^b Page 23a in: Merriam-Webster's collegiate dictionary. Springfield, Mass: Merriam-Webster, Inc. 2003. ISBN 0-87779-809-5.
^ Polyomaviridae 2004 Stanford University. Referring to the Seventh Report of the International Committee on Taxonomy of Viruses

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English Journal

Progressive multifocal leukoencephalopathy.

Aksamit AJ Jr.AbstractABSTRACT: Purpose of Review: Progressive multifocal leukoencephalopathy (PML) is an opportunistic viral infection of the human CNS that has gained new importance because of AIDS and newer immunosuppressive therapies. It destroys oligodendrocytes, leading to neurologic deficits associated with demyelination.Recent Findings: PML most commonly occurs in patients who are HIV infected, but increasing numbers of patients are being recognized in the context of immunosuppressive therapies for autoimmune diseases. The precise pathogenesis of infection by JC virus, the etiologic human papovavirus, remains elusive, but much has been learned since the original description of the pathologic entity PML in 1958. Detection and diagnosis of this disorder have become more sophisticated with MRI of the brain and spinal fluid analysis using PCR detection. Immune reconstitution inflammatory syndrome complicates reversal of immunosuppression when PML has established a foothold in the brain.Summary: No effective therapy exists, but there is hope for better management of patients by withdrawing exogenous immunosuppression and reconstituting the immune system, with a projection of better long-term survival.
Continuum (Minneapolis, Minn.).Continuum (Minneap Minn).2012 Dec;18(6 Infectious Disease):1374-91. doi: 10.1212/01.CON.0000423852.70641.de.
ABSTRACT: Purpose of Review: Progressive multifocal leukoencephalopathy (PML) is an opportunistic viral infection of the human CNS that has gained new importance because of AIDS and newer immunosuppressive therapies. It destroys oligodendrocytes, leading to neurologic deficits associated with demyel
PMID 23221846

Development and characterization of transgenic mouse models for conditional gene knockout in the blood-brain and blood-CSF barriers.

Crouthamel MH, Kelly EJ, Ho RJ.SourceDepartment of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195-7610, USA.
Transgenic research.Transgenic Res.2012 Feb;21(1):113-30. doi: 10.1007/s11248-011-9512-z. Epub 2011 May 3.
For many CNS acting drugs, penetration into the central nervous system (CNS) is limited by the blood-CNS-barriers. In an effort to quantitate the role of the protein components that make up the blood-CNS-barriers, we created transgenic mice that allow conditional gene knockout using Cre/loxP technol
PMID 21538071

Japanese Journal

パポーバウイルス : ウイルスの分子進化と感染個体内変異

余郷嘉明
ウイルス 52(1), 147-150, 2002-06-01
NAID 10009277305

Remission of progressive multifocal leukoencephalopathy following highly active antiretroviral therapy in a patient with HIV infection

INUI Koji,MIYAGAWA Hiromi,SASHIHARA Junji,MIYOSHI Hiroko,TANAKA-TAYA Keiko,NISHIGAKI Toshinori,TERAOKA Satori,MANO Toshiyuki,ONO Jiro,OKADA Shintaro
Brain & development 21(6), 416-419, 1999-09-01
NAID 10011564535

Virus production ,cell proliferation and cell death in progressive multifocal leukoencephalopathy

SATO-MATSUMURA Kazuko,HAINFEKKNER Johannes A,BUDKA Herbert
Neuropathology : official journal the Japanese Society of Neuropathology 18(2), 206-210, 1998-06-01
NAID 10011559151