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ヒトパピローマウイルス HPV human papillomavirus

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/04/03 18:34:12」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/09/11 21:48:50」(JST)

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  • [The testing strategy for detection of biologically relevant infection of human papillomavirus in head and neck tumors for routine pathological analysis].
  • Kašpírková J, Ondič O, Cerná K, Skálová A.AbstractThere is a subgroup among head and neck squamous cell carcinomas, which is etiologically linked to the infection of high-risk human papillomavirus (HPV). In recent studies, HPV related squamous cell carcinomas have been placed in a separate group because of their different epidemiology, distinctive histopathological characteristics, therapeutic response and clinical outcome. The reported prevalence of high-risk HPV in head and neck tumors varies in different studies. This fact occurs mainly due to the absence of a widely accepted consensus for HPV detection in head and neck malignancies. We present a methodological algorithm for detection of biologically relevant HPV infection: a combination of an immunohistochemical staining of the p16 protein - a surrogate marker for a transforming HPV infection, and a molecular genetic identification of HPV DNA by three different polymerase chain reactions (PCR). The study group consisted of 41 patients with a tumor in head and neck region. A verification of detection of biologically relevant HPV infection has been performed in 10 available samples using an alternative approach, which comprised the detection of RNA transcript of HPV by reverse transcription followed by PCR (RT-PCR), and further in situ hybridization (ISH) with a commercial high-risk HPV probe. We have found a high correlation between HPV DNA detection using triple-PCR approach and strong diffuse positivity of the p16 protein (correlation coefficient 0.94) and have confirmed the validity of this algorithm. In 94 % of HPV related squamous cell carcinomas HPV type 16 was detected. In one case HPV type 33 was identified. That is in agreement with earlier published data. A more appropriate alternative method for the detection of biologically relevant- transforming HPV infection seems to be RT-PCR, which proved 100 % agreement with the original methodological approach of p16 determination and PCR status. Interpretation of the ISH has been complicated by frequent nonspecific staining of the sample and its routine usage in the diagnostic algorithm of our laboratory is currently not feasible.Keywords: HPV - squamous cell carcinoma - head and neck tumors - p16.
  • Ceskoslovenská patologie.Cesk Patol.2013 Dec;49(1):29-34.
  • There is a subgroup among head and neck squamous cell carcinomas, which is etiologically linked to the infection of high-risk human papillomavirus (HPV). In recent studies, HPV related squamous cell carcinomas have been placed in a separate group because of their different epidemiology, distinctive
  • PMID 23432073
  • Expression, purification and characterization of a recombinant fusion protein based on the human papillomavirus-16 E7 antigen.
  • Granadillo M, Batte A, Lugo VM, Musacchio A, Bequet-Romero M, Betancourt L, Besada V, Javier L, Molina R, Falcón V, Torrens I.SourceCenter for Genetic Engineering and Biotechnology, P.O. Box 6162, Cubanacan, Playa, Havana, 10600 Cuba.
  • SpringerPlus.Springerplus.2013 Dec;2(1):12. Epub 2013 Jan 12.
  • A fusion protein comprising a cell penetrating and immunostimulatory peptide corresponding to residues 32 to 51 of the Limulus polyphemus protein linked to human papillomavirus (HPV)-16 E7 antigen (LALF32-51-E7) was expressed in E. coli BL21 (DE3) cells. The recombinant protein in E. coli accounted
  • PMID 23483788
  • Radiation-induced loss of cell surface CD47 enhances immune-mediated clearance of human papillomavirus-positive cancer.
  • Vermeer DW, Spanos WC, Vermeer PD, Bruns AM, Lee KM, Lee JH.SourceCancer Biology Research Center, Sanford Research/University of South Dakota, Sioux Falls, SD.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2013 Jul;133(1):120-9. doi: 10.1002/ijc.28015. Epub 2013 Feb 12.
  • The increasing incidence of human papillomavirus (HPV) related oropharyngeal squamous cell carcinoma (OSSC) demands development of novel therapies. Despite presenting at a more advanced stage, HPV(+) oropharyngeal squamous cell carcinoma (OSCC) have a better prognosis than their HPV(-) counterparts.
  • PMID 23292955


  • HPVワクチンと自己免疫性疾患 (特集 リウマチ性疾患とウイルス感染の関連)
  • 臨床免疫・アレルギー科 = Clinical immunology & allergology 66(5), 460-464, 2016-11
  • NAID 40021020499
  • Synergistic antitumor effect of a human papillomavirus DNA vaccine harboring E6E7 fusion gene and vascular endothelial growth factor receptor 2 gene
  • Label-free detection of real-time DNA amplification using a nanofluidic diffraction grating


HPV - What is genital HPV infection? How common is it? How does HPV cause genital warts and cancer? ... Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. Some health effects ...
papillomavirus [pap″ĭ-lo´mah-vi″rus] any member of a genus of viruses that cause papillomas in humans and various other animals. human papillomavirus any of numerous species that cause warts, particularly plantar and venereal warts ...



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