WordNet

(botany) a tiny outgrowth on the surface of a petal or leaf
a small nipple-shaped protuberance concerned with taste, touch, or smell; "the papillae of the tongue"
a small projection of tissue at the base of a hair or tooth or feather
of or relating to or resembling papilla (同)papillose
malignant tumor originating in glandular epithelium (同)glandular cancer, glandular_carcinoma

PrepTutorEJDIC

乳頭;(毛根・歯根などにある)微小乳頭状突起物

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/07 18:56:18」(JST)

wiki en

Papillary adenocarcinoma is a histological form of lung cancer that is diagnosed when the malignant cells of the tumor form complex papillary structures and exhibit compressive, destructive growth that replaces the normal lung tissue.^[1]

References[edit]

^ Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC (Eds.): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press: Lyon, France 2004.

External links[edit]

[1] World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (Download Page).
[2] Lung cancer page at the National Cancer Institute.

UpToDate Contents

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1. 原発不明の腺癌 adenocarcinoma of unknown primary site
2. 肺悪性腫瘍の病理 pathology of lung malignancies
3. 甲状腺乳頭癌の概要 overview of papillary thyroid cancer
4. 悪性腹膜中皮腫：治療 malignant peritoneal mesothelioma treatment
5. 高リスクの子宮体癌に対する補助化学療法 adjuvant treatment of high risk endometrial cancers

English Journal

GNAS Sequencing Identifies IPMN-specific Mutations in a Subgroup of Diminutive Pancreatic Cysts Referred to as "Incipient IPMNs".

Matthaei H1, Wu J, Dal Molin M, Shi C, Perner S, Kristiansen G, Lingohr P, Kalff JC, Wolfgang CL, Kinzler KW, Vogelstein B, Maitra A, Hruban RH.Author information 1Departments of *Pathology ††Oncology #Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine ‡Ludwig Center for Cancer Genetics **Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD §Department of Pathology, Microbiology, Immunology, Vanderbilt University Medical Center, Nashville, TN Departments of †General, Visceral, Thoracic and Vascular Surgery ¶Prostate Cancer Research ∥Institute of Pathology, University of Bonn, Bonn, Germany.AbstractIncipient intraductal papillary mucinous neoplasms (IPMNs) are poorly described subcentimeter pancreatic cysts with papillae and mucin similar to IPMNs. They are larger than pancreatic intraepithelial neoplasia but do not meet the cutoff size for IPMNs (≥1 cm). GNAS codon 201 mutations are hallmark genetic alterations of IPMNs. Hence, we sought to determine the GNAS status of incipient IPMNs to better classify these lesions. Incipient IPMNs from 3 institutions were histologically reassessed, manually microdissected, and the genomic DNA was extracted. Using a sensitive digital ligation technique, the mutational status of KRAS at codon 12 and GNAS at codon 201 was determined. We included 21 incipient IPMNs from 7 male and 12 female patients with a median age of 63 years (range, 40 to 76 y). Most patients underwent surgery for pancreatic ductal adenocarcinoma (N=8) or ampullary adenocarcinoma (N=3). The median incipient IPMN size was 4 mm (range, 2 to 7 mm), and a majority had gastric-foveolar (N=11) or intestinal (N=5) differentiation. The maximum dysplasia observed was intermediate, and most of the lesions had intermediate-grade dysplasia. Mutational analysis revealed KRAS codon 12 mutations in all 21 incipient IPMNs, whereas 7 lesions (33%) in 7 individual patients harbored GNAS codon 201 mutations. The presence of GNAS 201 mutations in incipient IPMNs suggests that a fraction of these cysts are in fact small IPMNs. Morphologically, incipient IPMNs do not appear to be high-risk lesions. Additional studies in a larger cohort are needed to define the relationship of incipient IPMNs to larger IPMNs and, more importantly, to determine their clinical significance.
The American journal of surgical pathology.Am J Surg Pathol.2014 Mar;38(3):360-3. doi: 10.1097/PAS.0000000000000117.
Incipient intraductal papillary mucinous neoplasms (IPMNs) are poorly described subcentimeter pancreatic cysts with papillae and mucin similar to IPMNs. They are larger than pancreatic intraepithelial neoplasia but do not meet the cutoff size for IPMNs (≥1 cm). GNAS codon 201 mutations are hallmar
PMID 24525507

Papillary eccrine adenoma should not be mistaken for aggressive digital papillary adenocarcinoma.

Asgari M1, Chen S.
Clinical and experimental dermatology.Clin Exp Dermatol.2014 Mar;39(2):223-4. doi: 10.1111/ced.12231. Epub 2013 Nov 26.
PMID 24274672

SOX9: a useful marker for pancreatic ductal lineage of pancreatic neoplasms.

Shroff S1, Rashid A1, Wang H2, Katz MH3, Abbruzzese JL2, Fleming JB3, Wang H4.Author information 1Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX77030, USA.2Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.3Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.4Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX77030, USA. Electronic address: hmwang@mdanderson.org.AbstractPrevious studies showed that SOX9 plays a critical role in pancreatic ductal development. The aim of this study was to evaluate SOX9 as a marker for pancreatic ductal lineage. SOX9 expression was evaluated by immunohistochemistry in 146 benign pancreas (BP), 136 pancreatic ductal adenocarcinomas, 47 pancreatic intraepithelial neoplasia (PanIN), 21 intraductal papillary mucinous neoplasms (IPMNs), 14 mucinous cystic neoplasms, 10 serous cystadenomas, 39 pancreatic neuroendocrine tumors, 9 acinar cell carcinomas, and 23 solid pseudopapillary neoplasms. Nuclear expression of SOX9 was detected in the centroacinar cells and ductal cells, but not in acinar or endocrine cells in 100% BP. Focal or diffuse SOX9 expression was detected in 100% PanINs, 100% IPMNs, 100% mucinous cystic neoplasms, 100% serous cystadenomas, 89.0% pancreatic ductal adenocarcinomas, 2.6% pancreatic neuroendocrine tumors, 11.1% acinar cell carcinomas, and 0% solid pseudopapillary neoplasms. SOX9 expression was lower in PanIN2 and PanIN3 than in PanIN1 lesions (P < .01). Compared with BP, IPMN had lower SOX9 expression (P < .05). No correlation between SOX9 expression and other clinicopathologic parameters was identified. Our study showed that SOX9 is expressed in centroacinar and ductal epithelial cells of BP and is a useful marker for pancreatic ductal lineage of pancreatic neoplasms.
Human pathology.Hum Pathol.2014 Mar;45(3):456-63. doi: 10.1016/j.humpath.2013.10.008. Epub 2013 Oct 19.
Previous studies showed that SOX9 plays a critical role in pancreatic ductal development. The aim of this study was to evaluate SOX9 as a marker for pancreatic ductal lineage. SOX9 expression was evaluated by immunohistochemistry in 146 benign pancreas (BP), 136 pancreatic ductal adenocarcinomas, 47
PMID 24418153

Japanese Journal

後腹膜腔多発性嚢胞を形成した前立腺導管腺癌の1例

惣田哲次,福本亮,林哲也 [他]
泌尿器科紀要 = Acta urologica Japonica 58(10), 561-564, 2012-10
… A histopathological diagnosis was papillary adenocarcinoma positive for prostate specific antigen (PSA). … Because the level of serum PSA was 9.39 ng/ml, prostate biopsy was performed and ductal adenocarcinoma of prostate was revealed. … Ductal adenocarcinoma forming cysts is rare. …
NAID 40019492159

胸腺原発非乳頭状腺癌の1例

田中伸佳,松本勲,小田誠,滝沢昌也,早稲田龍一,渡邊剛
Japanese Journal of Lung Cancer 52(4), 375-380, 2012-08
… In particular, thymic non-papillary adenocarcinoma is extremely rare. … Histopathological findings showed thymic non-papillary adenocarcinoma, pT2N1M0, stage III, and Masaoka stage IVb. … We reported a case of thymic non-papillary adenocarcinoma of the anterior mediastinum. …
NAID 120004997023