pancreatic endocrine tumor

出典: meddic

膵内分泌腫瘍

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/11/25 19:22:56」(JST)

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英文文献

  • A MEN1 syndrome with a paraganglioma.
  • Jamilloux Y1, Favier J2, Pertuit M3, Delage-Corre M4, Lopez S5, Teissier MP5, Mathonnet M6, Galinat S5, Barlier A3, Archambeaud F5.Author information 11] Department of Internal Medicine A, University Hospital of Limoges, Limoges, France [2] Department of Internal Medicine B, Endocrinology and Metabolic Diseases, University Hospital of Limoges, Limoges, France.21] INSERM, UMR970, Paris Cardiovascular Research Center at HEGP, Paris, France [2] Medicine Faculty, University of Paris Descartes, Paris, France.3APHM - Conception, Laboratory of Molecular Biology, Aix-Marseille University, Marseille, France.4Department of Pathology, University Hospital of Limoges, Limoges, France.5Department of Internal Medicine B, Endocrinology and Metabolic Diseases, University Hospital of Limoges, Limoges, France.6Department of Surgery, University Hospital of Limoges, Limoges, France.AbstractGermline mutations of the MEN1 gene cause multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disorder characterized by tumors of the parathyroids, the pancreas, and the anterior pituitary. Paraganglioma (PGL) is a rare endocrine tumor, which can be sporadic or genetically determined. To date, PGL has never been reported as a feature of MEN1.We report here a patient presenting three features of MEN1 syndrome (hyperparathyroidism, pancreatic neuroendocrine tumor, and adrenocortical adenoma) associated with PGL. Genetic analysis of MEN1 gene revealed a new missense mutation in exon 5 (AGGAAG), causing the substitution of arginine by lysine at codon 275. Screening for other genetic disorders (SDHx, TMEM127, MAX, CDKN1B) causing PGL was negative. Immunohistochemical analyses showed normal levels of succinate dehydrogenase (SDH)A and SDHB in the PGL. The proband's sister, bearing the mutation, had primary hyperparathyroidism. It was the first typical MEN1 syndrome reported with an extra-adrenal PGL.
  • European journal of human genetics : EJHG.Eur J Hum Genet.2014 Feb;22(2):283-5. doi: 10.1038/ejhg.2013.128. Epub 2013 Jun 19.
  • Germline mutations of the MEN1 gene cause multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disorder characterized by tumors of the parathyroids, the pancreas, and the anterior pituitary. Paraganglioma (PGL) is a rare endocrine tumor, which can be sporadic or genetically determined.
  • PMID 23778871
  • Assessment of tumor growth in pancreatic neuroendocrine tumors in von hippel lindau syndrome.
  • Weisbrod AB1, Kitano M1, Thomas F2, Williams D2, Gulati N1, Gesuwan K1, Liu Y2, Venzon D3, Turkbey I2, Choyke P2, Yao J2, Libutti SK4, Nilubol N1, Linehan WM5, Kebebew E6.Author information 1Endocrine Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.2Diagnostic Radiology Department, Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda, MD.3Biostatistics and Data Management Section, Office of the Clinical Director, National Cancer Institute, National Institutes of Health, Bethesda, MD.4Department of Surgery, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY.5Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.6Endocrine Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD. Electronic address: kebebewe@mail.nih.gov.AbstractBACKGROUND: The incidence of pancreatic neuroendocrine tumors (PNETs) is increasing, but only a subset of these heterogeneous tumors will progress to malignant disease, which is associated with a poor prognosis. Currently, there are limited data on the natural history of these tumors and it is difficult to determine which patients require surgical intervention because the risk of metastatic disease cannot be accurately determined.
  • Journal of the American College of Surgeons.J Am Coll Surg.2014 Feb;218(2):163-9. doi: 10.1016/j.jamcollsurg.2013.10.025. Epub 2013 Nov 12.
  • BACKGROUND: The incidence of pancreatic neuroendocrine tumors (PNETs) is increasing, but only a subset of these heterogeneous tumors will progress to malignant disease, which is associated with a poor prognosis. Currently, there are limited data on the natural history of these tumors and it is diffi
  • PMID 24440063
  • Impact of long-acting octreotide in patients with early-stage MEN1-related duodeno-pancreatic neuroendocrine tumors.
  • Ramundo V, Del Prete M, Marotta V, Marciello F, Camera L, Napolitano V, De Luca L, Circelli L, Colantuoni V, Di Sarno A, Carratù AC, de Luca di Roseto C, Colao A, Faggiano A.Author information Departments of Clinical Medicine and Surgery, "Federico II" University of Naples.AbstractBACKGROUND: Somatostatin analogues (SSA) represent one of the main therapeutic option in patients affected with functioning well-differentiated neuroendocrine tumors (NETs). There are no studies specifically focusing on NETs associated to Multiple Endocrine Neoplasia type 1 (MEN1).
  • Clinical endocrinology.Clin Endocrinol (Oxf).2014 Jan 21. doi: 10.1111/cen.12411. [Epub ahead of print]
  • BACKGROUND: Somatostatin analogues (SSA) represent one of the main therapeutic option in patients affected with functioning well-differentiated neuroendocrine tumors (NETs). There are no studies specifically focusing on NETs associated to Multiple Endocrine Neoplasia type 1 (MEN1).AIM: To evaluate t
  • PMID 24443791

和文文献

  • 5. 膵神経内分泌腫瘍の外科(<特集>内分泌外科の現状と将来)
  • 柴田 近,江川 新一,元井 冬彦,森川 孝則,内藤 剛,海野 倫明,佐々木 巖
  • 日本外科学会雑誌 113(6), 502-506, 2012-11-01
  • NAID 110009554103
  • 内視鏡外科手術における研究と治療の進歩(4)内分泌外科領域
  • 飯原雅季
  • 東京女子医科大学雑誌 82(4), 187-192, 2012-08-25
  • 内分泌外科領域において進められてきた、副腎腫瘍、膵内分泌腫瘍、縦隔・胸腔内副甲状腺病変に対する内視鏡手術について概説した。腹腔鏡下副腎摘除術は原発性アルドステロン症やコルチゾール産生副腎腺腫によるクッシング症候群を中心に始まり、近年では良性副腎疾患はほとんどがその適応であるが、褐色細胞腫は腫瘍の大きさや発生部位により腹腔鏡手術が難しいことがある。両側副腎腫瘍に対する一期的腹腔鏡手術において副腎皮質 …
  • NAID 110009557329
  • 症例報告 完全嚢胞型を呈した膵内分泌腫瘍に対して腹腔鏡下膵体尾部切除を施行した2例
  • 山本 一仁,福原 宗久,二見 良平 他
  • 日本医科大学医学会雑誌 8(1), 44-49, 2012-02-00
  • NAID 40019210131

関連リンク

18 Jan 2013 ... Pancreatic neuroendocrine tumors form in hormone-making cells (islet cells) of the pancreas. ... A pancreatic neuroendocrine tumor (NET) may also be called a pancreatic endocrine tumor (PET), islet cell tumor, islet cell ...
Pancreatic neuroendocrine tumors (PETs or PNETs; not to be confused with the primitive neuroectodermal PNET) can originate within the pancreas or from similar neuroendocrine cells ...

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★リンクテーブル★
リンク元膵島細胞腫瘍」「膵内分泌腫瘍」「islet cell tumor
関連記事endocrine」「pancreatic」「tumor」「endocrine tumor

膵島細胞腫瘍」

  [★]

islet cell tumor, pancreatic endocrine tumor
膵島細胞腫膵島細胞腺腫膵島腫瘍膵小島腫瘍島細胞腫瘍
膵臓
ランゲルハンス島腫瘍ランゲルハンス島細胞腫瘍
ガストリン産生腫瘍グルカゴン産生腫瘍ソマトスタチン産生腫瘍
[show details]


  • 多血性
  • 造影CTの同脈相で強く濃染する
  • 膵臓から発生する内分泌腫瘍。
  • ランゲルハンス島由来の細胞から由来するが、一部膵管上皮や腺房細胞の間に存在する細胞に由来するものがある


膵内分泌腫瘍」

  [★]

pancreatic endocrine tumor, endocrine tumor of pancreas
膵内分泌性膿瘍、膵内分泌系腫瘍




islet cell tumor」

  [★] 膵島細胞腫瘍

pancreatic endocrine tumor


endocrine」

  [★]

  • n.
endocrinic, endocrinal

WordNet   license wordnet

「of or belonging to endocrine glands or their secretions; "endocrine system"」
endocrinal

PrepTutorEJDIC   license prepejdic

「内分泌(ぶんぴつ)の / 内分泌物;内分泌腺(せん)」


pancreatic」

  [★]

  • adj.
  • 膵臓の、膵性の、膵の
pancreaspancreata

WordNet   license wordnet

「of or involving the pancreas; "pancreatic cancer"」

PrepTutorEJDIC   license prepejdic

「膵臓の」


tumor」

  [★]

  • n.


WordNet   license wordnet

「an abnormal new mass of tissue that serves no purpose」
tumour, neoplasm


endocrine tumor」

  [★]

内分泌腫瘍内分泌腺腫瘍

endocrine gland neoplasmendocrine neoplasm




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