p53 gene

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/04 23:20:48」(JST)

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  • Hsp90-targeted miRNA-liposomal formulation for systemic antitumor effect.
  • Pore SK, Choudhary A, Rathore B, Ganguly A, Sujitha P, Ganesh Kumar C, Agawane SB, Kumar JM, Scaria V, Pillai B, Banerjee R.SourceDivision of Lipid Science & Technology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
  • Biomaterials.Biomaterials.2013 Sep;34(28):6804-17. doi: 10.1016/j.biomaterials.2013.05.054. Epub 2013 Jun 14.
  • Chaperone protein Hsp90 maintains functional integrity and maturation of a large number of cellular proteins including transcription factors, kinases, etc. It is often over-expressed in cancer cells for simultaneous maintenance of many non-regulated and/or genetically mutated proteins. Small molecul
  • PMID 23773821
  • Immunohistochemical expression and mutation study of Prohibitin gene in Indian female breast cancer cases.
  • Najm MZ, Zaidi S, Siddiqui WA, Husain SA.SourceDepartment of Biochemistry, Jamia Hamdard, New Delhi, India, biotechzeeshan@gmail.com.
  • Medical oncology (Northwood, London, England).Med Oncol.2013 Sep;30(3):614. doi: 10.1007/s12032-013-0614-8. Epub 2013 May 29.
  • Prohibitin (PHB1) is highly conserved and ubiquitously expressed protein. It is mapped to the chromosome 17q12-q21 locus, a region that has been reported to be genetically linked to early onset of breast cancer. Therefore, we carried out the population-based study in a total of 105 Indian female bre
  • PMID 23715748


  • TRIM29 negatively regulates p53 via inhibition of Tip60
  • Sho Takuya,Tsukiyama Tadasuke,Sato Tomonobu,Kondo Takeshi,Cheng Jun,Saku Takashi,Asaka Masahiro,Hatakeyama Shigetsugu
  • Biochimica et Biophysica Acta (BBA) : Molecular Cell Research 1813(6), 1245-1253, 2011-06
  • … Ataxia-telangiectasia group D (ATDC) was initially described as a gene related to AT. … Overexpression of TRIM29 promoted degradation and changed localization of Tip60 and reduced acetylation of p53 at lysine 120 by Tip60, resulting in enhancement of cell growth and transforming activity. …
  • NAID 80021797059


The official name of this gene is “tumor protein p53.” TP53 is the gene's official symbol. The TP53 gene is also known by other names, listed below. Read more about gene names and symbols on the About page.
A variety of studies carried out with the protein, and later with the gene encoding p53, indicated that it was an oncogene (Eliyahu et al. 1984, Jenkins et al. 1984, Parada et al. 1984, Eliyahu et al. 1985). This interpretation ...


Figure 1 : p53: a two-faced cancer gene tumor suppressor genesP53-GENE-Coverp53_gene Gallery For > Cell Cycle Checkpoints P53Primary information of p53 gene

リンク元TP53 gene

TP53 gene」



p53 gene



(遺伝子)p53 gene p53遺伝子
(蛋白質)p53 protein p53蛋白質


  • 癌抑制遺伝子
  • MDM2はp53と結合して安定化し、ユビキチン化を介してP53の分解に導く
  • 活性化ATM(DNA損傷などが引き金となる)はp53をリン酸化する
  • リン酸化されたp53は次の経路を活性化する




  [★] 遺伝子

WordNet   license wordnet

「(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"」
cistron, factor

PrepTutorEJDIC   license prepejdic




WordNet   license wordnet

「informal term for information; "give me the gen on your new line of computers"」