p38マイトジェン活性化プロテインキナーゼ

関: mitogen-activated protein kinase p38、p38 MAPK、p38 mitogen-activated protein kinase、p38 protein kinase

WordNet

make a map of; show or establish the features of details of; "map the surface of Venus"
to establish a mapping (of mathematical elements or sets) (同)represent
a diagrammatic representation of the earths surface (or part of it)
plan, delineate, or arrange in detail; "map ones future" (同)map out
depict as if on a map; "sorrow was mapped on the mothers face"
explore or survey for the purpose of making a map; "We havent even begun to map the many galaxies that we know exist"
locate within a specific region of a chromosome in relation to known DNA or gene sequences; "map the genes"
the 13th letter of the Roman alphabet (同)m
an enzyme that catalyzes the conversion of a proenzyme to an active enzyme

PrepTutorEJDIC

(1枚1枚の)『地図』;天体図 / …‘の'地図を作る;…‘を'地図にかく
Mach number / mark[s] / Monsieur
Massachusetts / mental age

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/11 11:12:39」(JST)

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[Wiki en表示]

P38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy. Persistent activation of the p38 MAPK pathway in muscle satellite cells (muscle stem cells) due to ageing, impairs muscle regeneration.^[1]

p38 MAP Kinase (MAPK), also called RK or CSBP (Cytokinin Specific Binding Protein), is the mammalian orthologue of the yeast Hog1p MAP kinase,^[2] which participates in a signaling cascade controlling cellular responses to cytokines and stress.

Four p38 MAP kinases, p38-α (MAPK14), -β (MAPK11), -γ (MAPK12 / ERK6), and -δ (MAPK13 / SAPK4), have been identified. Similar to the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), Ultraviolet light, and growth factors.

mitogen-activated protein kinase 14
Identifiers
Symbol	MAPK14
Alt. symbols	CSPB1, CSBP1, CSBP2
Entrez	1432
HUGO	6876
OMIM	600289
RefSeq	NM_001315
UniProt	Q16539
Other data
EC number	2.7.11.24
Locus	Chr. 6 p21.3-21.2

MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr-180 and Tyr-182. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase 2 and to phosphorylate the transcription factors ATF2, Mac and MEF2. p38 also has been shown to phosphorylate post-transcriptional regulating factors like TTP.^[3]

P38 inhibitors

P38 inhibitors are being sought for possible therapeutic effect on autoimmune diseases and inflammatory processes,^[4] e.g. pamapimod.^[5] Some have started clinical trials, e.g. PH-797804 for COPD.^[6] Other p38 inhibitors include BIRB 796, VX-702, SB 239063, SB202190, SCIO 469, and BMS 582949.

References

^ Segalés J, Perdiguero E, Muñoz-Cánoves P (2016). "Regulation of Muscle Stem Cell Functions: A Focus on the p38 MAPK Signaling Pathway". FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 4: 91. doi:10.3389/fcell.2016.00091. PMC 5003838. PMID 27626031.
^ Han J, Lee JD, Bibbs L, Ulevitch RJ (August 1994). "A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells". Science. 265 (5173): 808–11. doi:10.1126/science.7914033. PMID 7914033.
^ Tudor C, Marchese FP, Hitti E, Aubareda A, Rawlinson L, Gaestel M, Blackshear PJ, Clark AR, Saklatvala J, Dean JL (June 2009). "The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages". FEBS Lett. 583 (12): 1933–8. doi:10.1016/j.febslet.2009.04.039. PMID 19416727.
^ Goldstein DM, Gabriel T (2005). "Pathway to the clinic: inhibition of P38 MAP kinase. A review of ten chemotypes selected for development". Current topics in medicinal chemistry. 5 (10): 1017–29. doi:10.2174/1568026054985939. PMID 16178744.
^ Hill RJ, Dabbagh K, Phippard D, Li C, Suttmann RT, Welch M, Papp E, Song KW, Chang KC, Leaffer D, Kim YN, Roberts RT, Zabka TS, Aud D, Dal Porto J, Manning AM, Peng SL, Goldstein DM, Wong BR (December 2008). "Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity". J. Pharmacol. Exp. Ther. 327 (3): 610–9. doi:10.1124/jpet.108.139006. PMID 18776065.
^ "Novel p38 Inhibitor Shows Promise as Anti-Inflammatory Treatment for Patients With COPD". 2010.

External links

p38 Mitogen-Activated Protein Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
P38mapkPathway
p38 Signaling Pathway
MAP Kinase Resource
p38 MAPK Pathway

This EC 2.7 enzyme-related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
2. 前立腺癌の分子生物学 molecular biology of prostate cancer
3. 免疫系に対するステロイドの影響 glucocorticoid effects on the immune system
4. 疾患状態における冠微小循環 the coronary microcirculation in disease states
5. クローン病の内科的管理における試験研究治療 investigational therapies in the medical management of crohns disease

English Journal

Sepsis protects the myocardium and other organs from subsequent ischaemic/reperfusion injury via a MAPK-dependent mechanism.

Walshe CM1, Laffey JG, Kevin L, O'Toole D.
Intensive care medicine experimental.Intensive Care Med Exp.2015 Dec;3(1):35. doi: 10.1186/s40635-014-0035-9. Epub 2015 Jan 31.
BACKGROUND: Sepsis has been shown to precondition the intact heart against ischaemia/reperfusion (IR) injury, and prior endotoxin exposure of cells in in vitro models has shown evidence of protection against subsequent simulated ischaemia. Our aim in this study is to validate these findings and furt
PMID 26215802

MicroRNA-155 Regulates ROS Production, NO Generation, Apoptosis and Multiple Functions of Human Brain Microvessel Endothelial Cells Under Physiological and Pathological Conditions.

Liu Y1, Pan Q1, Zhao Y2, He C1, Bi K1, Chen Y1, Zhao B1, Chen Y1,2, Ma X1.
Journal of cellular biochemistry.J Cell Biochem.2015 Dec;116(12):2870-81. doi: 10.1002/jcb.25234.
The microRNA-155 (miR155) regulates various functions of cells. Dysfunction or injury of endothelial cells (ECs) plays an important role in the pathogenesis of various vascular diseases. In this study, we investigated the role and potential mechanisms of miR155 in human brain microvessel endothelial
PMID 26012521

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis.

Sun Y1, Liu WZ1, Liu T1, Feng X1, Yang N1, Zhou HF1.
Journal of receptor and signal transduction research.J Recept Signal Transduct Res.2015 Dec;35(6):600-4. doi: 10.3109/10799893.2015.1030412. Epub 2015 Jun 22.
The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase (
PMID 26096166

Japanese Journal

Therapeutic targets in the ASK1-dependent stress signaling pathways

Hayakawa Ryoichi,Hayakawa Teruyuki,Takeda Kohsuke,Ichijo Hidenori
Proceedings of the Japan Academy, Series B 88(8), 434-453, 2012-10-11
… Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogenactivated protein kinase kinase kinase (MAP3K) family that activates downstream MAP kinases (MAPKs), c-Jun N-terminal kinases (JNKs) and p38 MAPKs, in response to various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide, and calcium overload. …
NAID 120005230515

ヒト歯肉由来線維芽細胞のMMP-1産生に及ぼす p38 MAP kinase の影響

氏井庸介,合田征司,松本尚之
歯科医学 75(2), 83-84, 2012-09-25
NAID 10030873830

Accumulating Microglia Phagocytose Injured Neurons in Hippocampal Slice Cultures : Involvement of p38 MAP Kinase

Katayama Takahiro,Kobayashi Hayato,Okamura Toshiyuki,Yamasaki-Katayama Yuko,Kibayashi Tatsuya,Kimura Hiroshi,Ohsawa Keiko,Kohsaka Shinichi,Minami Masabumi
PLoS One 7(7), e40813, 2012-07-17
… Using this advantage to examine microglial phagocytosis in living slice cultures, we investigated the involvements of mitogen-activated protein (MAP) kinases in microglial accumulation and phagocytosis. …
NAID 120004448534

Related Pictures

★リンクテーブル★

リンク元	「p38 mitogen-activated protein kinase」「p38マイトジェン活性化プロテインキナーゼ」「p38 MAPK」「mitogen-activated protein kinase p38」「p38 protein kinase」
関連記事	「map」「MAP」「MA」「kinase」「M」

「p38 mitogen-activated protein kinase」

mitogen-activated protein kinase 13
Identifiers
Symbol	MAPK13
Alt. symbols	PRKM13
Entrez	5603
HUGO	6875
OMIM	602899
RefSeq	NM_002754
UniProt	O15264
Other data
EC number	2.7.11.24
Locus	Chr. 6 p21

mitogen-activated protein kinase 12
Identifiers
Symbol	MAPK12
Alt. symbols	SAPK3
Entrez	6300
HUGO	6874
OMIM	602399
RefSeq	NM_002969
UniProt	P53778
Other data
EC number	2.7.11.24
Locus	Chr. 22 q13.3

mitogen-activated protein kinase 11
Identifiers
Symbol	MAPK11
Alt. symbols	PRKM11
Entrez	5600
HUGO	6873
OMIM	602898
RefSeq	NM_002751
UniProt	Q15759
Other data
EC number	2.7.11.24
Locus	Chr. 22 q13.33

　　[★]

MAPキナーゼp38、p38-MAPキナーゼ、p38マイトジェン活性化プロテインキナーゼ

関: mitogen-activated protein kinase p38、p38 MAP kinase、p38 MAPK、p38 protein kinase

「p38マイトジェン活性化プロテインキナーゼ」

　　[★]

英: p38 mitogen-activated protein kinase、p38 MAP kinase、p38 MAPK、mitogen-activated protein kinase p38
関: p38プロテインキナーゼ、MAPキナーゼp38、p38-MAPキナーゼ

「p38 MAPK」

　　[★]

p38マイトジェン活性化プロテインキナーゼ

関: mitogen-activated protein kinase p38、p38 MAP kinase、p38 mitogen-activated protein kinase、p38 protein kinase

「mitogen-activated protein kinase p38」

　　[★]

p38マイトジェン活性化プロテインキナーゼ、MAPキナーゼp38

関: p38 MAP kinase、p38 MAPK、p38 mitogen-activated protein kinase、p38 protein kinase

「p38 protein kinase」

　　[★]

p38プロテインキナーゼ

関: mitogen-activated protein kinase p38、p38 MAP kinase、p38 MAPK、p38 mitogen-activated protein kinase

「map」

　　[★]

n.

地図、マップ

v.

地図で表す、(遺伝子などを)位置づける、(遺伝子などが)位置する

関: lie、locate、location、loci、locus、mapping、position、rank、sit、situated、situation、stand、topo

「MAP」

　　[★]

僧帽弁輪形成術 mitral annuloplasty
Miller assessment for Pre-schoolers
平均動脈圧 mean arterial pressure
平均気道内圧 mean airway pressure
mannitol adenine phosphate
リン酸アンモニウムマグネシウム magnesium ammonium phosphate

「MA」

　　[★]

「kinase」

　　[★] キナーゼカイネースリン酸化酵素 phosphoenzyme phosphotransferase 　

「M」

　　[★] メチオニン methionine 　　

[pmid27626031-1] Segalés J, Perdiguero E, Muñoz-Cánoves P (2016). "Regulation of Muscle Stem Cell Functions: A Focus on the p38 MAPK Signaling Pathway". FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 4: 91. doi:10.3389/fcell.2016.00091. PMC 5003838. PMID 27626031.

[pmid7914033-2] Han J, Lee JD, Bibbs L, Ulevitch RJ (August 1994). "A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells". Science. 265 (5173): 808–11. doi:10.1126/science.7914033. PMID 7914033.

[pmid19416727-3] Tudor C, Marchese FP, Hitti E, Aubareda A, Rawlinson L, Gaestel M, Blackshear PJ, Clark AR, Saklatvala J, Dean JL (June 2009). "The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages". FEBS Lett. 583 (12): 1933–8. doi:10.1016/j.febslet.2009.04.039. PMID 19416727.

[pmid16178744-4] Goldstein DM, Gabriel T (2005). "Pathway to the clinic: inhibition of P38 MAP kinase. A review of ten chemotypes selected for development". Current topics in medicinal chemistry. 5 (10): 1017–29. doi:10.2174/1568026054985939. PMID 16178744.

[pmid18776065-5] Hill RJ, Dabbagh K, Phippard D, Li C, Suttmann RT, Welch M, Papp E, Song KW, Chang KC, Leaffer D, Kim YN, Roberts RT, Zabka TS, Aud D, Dal Porto J, Manning AM, Peng SL, Goldstein DM, Wong BR (December 2008). "Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity". J. Pharmacol. Exp. Ther. 327 (3): 610–9. doi:10.1124/jpet.108.139006. PMID 18776065.

[6] "Novel p38 Inhibitor Shows Promise as Anti-Inflammatory Treatment for Patients With COPD". 2010.

v t e Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

匿名

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案内

案内

p38 MAP kinase