オキシフェンブタゾン
WordNet
- an anti-inflammatory drug (trade name Tandearil) used to treat arthritis and bursitis (同)Tandearil
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/10/03 16:35:46」(JST)
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Oxyphenbutazone
|
Systematic (IUPAC) name |
(RS)-4-butyl-1-(4-hydroxyphenyl)-2-phenylpyrazolidine-3,5-dione
|
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Identifiers |
CAS Number |
129-20-4 Y |
ATC code |
M01AA03 (WHO) M02AA04 (WHO) S01BC02 (WHO) |
PubChem |
CID 104811 |
DrugBank |
DB03585 Y |
ChemSpider |
94610 Y |
UNII |
A7D84513GV Y |
KEGG |
D08324 Y |
ChEBI |
CHEBI:76258 N |
ChEMBL |
CHEMBL1228 N |
Chemical data |
Formula |
C19H20N2O3 |
Molar mass |
324.379 g/mol |
Chirality |
Racemic mixture |
SMILES
-
O=C2N(c1ccc(O)cc1)N(C(=O)C2CCCC)c3ccccc3.O
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InChI
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InChI=1S/C19H20N2O3.H2O/c1-2-3-9-17-18(23)20(14-7-5-4-6-8-14)21(19(17)24)15-10-12-16(22)13-11-15;/h4-8,10-13,17,22H,2-3,9H2,1H3;1H2 Y
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Key:CNDQSXOVEQXJOE-UHFFFAOYSA-N Y
|
NY (what is this?) (verify) |
Oxyphenbutazone is a non-steroidal anti-inflammatory drug (NSAID).[1] It is a metabolite of phenylbutazone.[2]
Scrabble
The word oxyphenbutazone is part of the single play yielding the highest possible score under American tournament Scrabble rules, scoring 1,780 points across three triple-word-score squares, joining seven tiles to eight already-played tiles.[3]
References
- ^ Singh, N.; Jabeen, T.; Somvanshi, R. K.; Sharma, S.; Dey, S.; Singh, T. P. (2004). "Phospholipase A2as a Target Protein for Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Crystal Structure of the Complex Formed between Phospholipase A2and Oxyphenbutazone at 1.6 Å Resolution†". Biochemistry. 43 (46): 14577–14583. doi:10.1021/bi0483561. PMID 15544328.
- ^ Matthews, N. S.; Peck, K. E.; Taylor, T. S.; Mealey, K. L. (2001). "Pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in miniature donkeys". American journal of veterinary research. 62 (5): 673–675. PMID 11341383.
- ^
- Record for the Highest Scoring Scrabble Move at scrabulizer.com, accessed 2008-05-30
- How the word oxyphenbutazone is played in Scrabble on Facebook accessed 2010-01-28
Topical products for joint and muscular pain (M02)
|
|
Anti-inflammatory
preparations,
non-steroids |
Pyrazolidines |
- Phenylbutazone
- Mofebutazone
- Clofezone
- Oxyphenbutazone
|
|
Acetic acid
derivatives |
- Tolmetin
- Diclofenac
- Fentiazac
|
|
Other |
- Benzydamine
- Etofenamate
- Piroxicam
- Felbinac
- Bufexamac
- Ketoprofen
- Bendazac
- Naproxen
- Ibuprofen
- Feprazone
- Niflumic acid
- Meclofenamic acid
- Flurbiprofen
- Suxibuzone
- Indometacin
- Nifenazone
|
|
|
Capsaicin derivatives |
|
|
Other |
- Tolazoline
- Dimethyl sulfoxide
- Idrocilamide
|
UpToDate Contents
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English Journal
- Investigation of phenylbutazone and its metabolite oxyphenbutazone in horse meat products during years 2013-2017.
- Annunziata L1, Visciano P2, Stramenga A3, Colagrande MN1, Campana G1, Scortichini G3, Migliorati G1, Compagnone D2.
- Drug testing and analysis.Drug Test Anal.2018 Mar 22. doi: 10.1002/dta.2386. [Epub ahead of print]
- PMID 29569348
- Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors.
- Zhu MR1,2, Du DH2, Hu JC2, Li LC2, Liu JQ2, Ding H2, Kong XQ2,3, Jiang HL2, Chen KX2, Luo C2,4.
- Acta pharmacologica Sinica.Acta Pharmacol Sin.2018 Feb;39(2):302-310. doi: 10.1038/aps.2017.59. Epub 2017 Aug 31.
- PMID 28858300
- Oxyphenbutazone promotes cytotoxicity in rats and Hep3B cellsvia suppression of PGE2 and deactivation of Wnt/β-catenin signaling pathway.
- Saleem S1, Khan R2, Afzal M3, Kazmi I4.
- Molecular and cellular biochemistry.Mol Cell Biochem.2017 Dec 4. doi: 10.1007/s11010-017-3243-2. [Epub ahead of print]
- PMID 29204817
Japanese Journal
- Phospholipase A_2 as a target protein for nonsteroidal anti-inflammatory drugs (NSAIDS) : crystal structure of the complex formed between phospholipase A_2 and oxyphenbutazone at 1.6 A resolution
- Determination of phenylbutazone and oxyphenbutazone in plasma and urine samples of horses by high-performance liquid chromatography and gas chromatography-mass spectrometry
- NETO Luciane M. R,ANDRAUS Maristela H.,SALVADORI Myriam C.
- Journal of chromatography. B, Biomedical applications 678(2), 211-218, 1996-04-12
- NAID 10024554359
- Characterization of High Affinity Binding Sites of Non-steroidal Anti-inflammatory Drugs with Respect to Site-Specific Probes on Human Serum Albumin
- / 山崎 啓之,山崎 啓之,辛 英姫,林 嘉虔,小田切 優樹
- Biological & Pharmaceutical Bulletin 16(11), 1169-1174, 1993-11-15
- … A site-oriented study of nine non-steroidal anti-inflammatory drugs (NSAIDs), suprofen, ibuprofen, diclofenac sodium, pirprofen, flurbiprofen, ketoprofen, phenylbutazone, oxyphenbutazone, and ketophenylbutazone, on human serum albumin (HSA) was carried out at pH 7.4 by various direct and indirect methods to gain insignt into the high affinity binding sites of NSAIDs. …
- NAID 110003663269
Related Links
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- a video showing how to play the word "oxyphenbutazone" in the scrabble application for facebook.
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