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The management of overactive bladder: percutaneous tibial nerve stimulation, sacral nerve stimulation, or botulinum toxin?

Tubaro A1, Puccini F, De Nunzio C.
Current opinion in urology.Curr Opin Urol.2015 Jul;25(4):305-10. doi: 10.1097/MOU.0000000000000180.
PURPOSE OF REVIEW: We have reviewed the evidence published on botulinum toxin A (BoNT/A), percutaneous tibial nerve stimulation (PTNS), and sacral nerve stimulation (SNS) in the management of overactive bladder (OAB).RECENT FINDINGS: BoNT/A is effective irrespectively of the number of previous antic
PMID 26049873

Investigating Detrusor Muscle Concentrations of Oxybutynin After Intravesical Delivery in an Ex Vivo Porcine Model.

Williams NA1, Lee KM1, Allender CJ1, Bowen JL1, Gumbleton M1, Harrah T2, Raja A3, Joshi HB3.
Journal of pharmaceutical sciences.J Pharm Sci.2015 Jul;104(7):2233-40. doi: 10.1002/jps.24471. Epub 2015 May 18.
Intravesical oxybutynin is highly effective in the treatment of overactive bladder. Traditionally the mechanism of action was explained by antagonism of muscarinic receptors located in the detrusor, however evidence now suggests antimuscarinics may elicit their effect by modifying afferent pathways
PMID 25989054

Oxybutynin as a treatment for generalized hyperhidrosis: a randomized, placebo-controlled trial.

Schollhammer M1,2, Brenaut E2, Menard-Andivot N3, Pillette-Delarue M1,2, Zagnoli A4, Chassain-Le Lay M1, Sassolas B5, Jouan N1,2, Le Ru Y1, Abasq-Thomas C2, Greco M1,2, Penven K1, Roguedas-Contios AM2, Dupré-Goetghebeur D4, Gouedard C4, Misery L2, Le Gal G6.
The British journal of dermatology.Br J Dermatol.2015 Jun 26. doi: 10.1111/bjd.13973. [Epub ahead of print]
BACKGROUND: Hyperhidrosis is a disorder that can impair quality of life. Localized treatments may be cumbersome and ineffective, and no systemic treatments have proven to be significantly beneficial.OBJECTIVES: To evaluate the effectiveness and tolerance of low-dose oxybutynin for hyperhidrosis.METH
PMID 26114588

花輪剛久,土屋千佳子,遠藤尚子,花輪和己,鈴木妙子,毛利公則,鈴木正彦,小口敏夫
医療薬学 37(1), 31-40, 2011
… Oxybutynin hydrochloride (OB) is often used in intravesical instillation therapy for spastic neurogenetic bladder.The purposeof this study was to determine the expiration date and administration device for intravesically administered OB solutionscontaining sodium hyaluronate (HYA) as a pharmaceutical additive to enhance the muco-adhesiveness of the solution.The stability of OB in containers made of glass,polystyrene (PS),polypropylene (PP) and polyethylene (PE) was investigatedunder various temperature and light exposure …
NAID 130004502650

Application of Oxybutynin Selective Sensors for Monitoring the Dissolution Profile and Assay of Pharmaceutical Dosage Forms

El Hamshary Marwa S.,Salem Omar H.,El Nashar Rasha M.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 26(4), 437-442, 2010-04-10
… Two ion-selective sensors of the plastic membrane type were prepared for the determination of oxybutynin hydrochloride (OxCl). …
NAID 10026782888