oxazolone

オキサゾロン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/13 05:39:40」(JST)

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Oxazolone is a chemical allergen used for immunological experiments, particularly for experiments on delayed type hypersensitivity. Its systematic chemical name is 4-ethoxymethylene-2-phenyloxazol-5-one and it is commercially available.

References

• Nakano, Y. (2004). Stress-induced modulation of skin immune function: two types of antigen-presenting cells in the epidermis are differentially regulated by chronic stress. 151: 50-64.

See also

• DNCB

English Journal

• PACAP is an Endogenous Protective Factor-Insights from PACAP-Deficient Mice.

• Reglodi D, Kiss P, Szabadfi K, Atlasz T, Gabriel R, Horvath G, Szakaly P, Sandor B, Lubics A, Laszlo E, Farkas J, Matkovits A, Brubel R, Hashimoto H, Ferencz A, Vincze A, Helyes Z, Welke L, Lakatos A, Tamas A.SourceDepartment of Anatomy, PTE-MTA "Lendulet" PACAP Research Group, University of Pecs, 7624, Pecs, Szigeti u 12, Hungary, dora.reglodi@aok.pte.hu.
• Journal of molecular neuroscience : MN.J Mol Neurosci.2012 Nov;48(3):482-92. Epub 2012 Apr 14.
• Pituitary adenylate cyclase-activating polypeptide (PACAP) is a widespread neuropeptide with a diverse array of biological functions. Not surprisingly, the lack of endogenous PACAP therefore results in a variety of abnormalities. One of the important effects of PACAP is its neuroprotective and gener
• PMID 22528455

• Topical administration of the pan-Src kinase inhibitors, dasatinib and LCB 03-0110, prevents allergic contact dermatitis in mice.

• Jung SH, Sun X, Ryu WS, Yang BS.SourceChemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul, Korea Department of Biochemistry, Yonsei University, Seoul, Korea.
• The British journal of dermatology.Br J Dermatol.2012 Sep 28. doi: 10.1111/bjd.12069. [Epub ahead of print]
• Background:  Allergic contact dermatitis (ACD) is a delayed type of T cell-mediated cutaneous inflammatory response, in which multiple cell types are involved. Dasatinib and LCB 03-0110 are small molecule multi-tyrosine kinase inhibitors, and they share remarkably similar target kinases such as th
• PMID 23020072

Japanese Journal

• One-Pot Preparation of Oxazol-5(4H)-ones from Amino Acids in Aqueous Solvents

• Fujita Hikaru,Kunishima Munetaka
• Chemical and pharmaceutical bulletin 60(7), 907-912, 2012-07
• NAID 40019318433

• Gabapentin and Pregabalin Inhibit the Itch-Associated Response Induced by the Repeated Application of Oxazolone in Mice

• TSUKUMO Yukihito,MATSUMOTO Yuichi,MIURA Hiroko,YANO Hiroshi,MANABE Haruhiko
• Journal of pharmacological sciences 115(1), 27-35, 2011-01-20
• … We investigated the effects of gabapentin and pregabalin on the itch-associated response in a mouse model of chronic dermatitis induced by the repeated application of 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone). … Challenging the mice with oxazolone-induced chronic dermatitis with the oxazolone evoked severe and transient scratching behavior until 1 h after the application of oxazolone. …
• NAID 10029891407

Related Links

• Oxazolone - Wikipedia, the free encyclopedia

Oxazolone is a chemical allergen used for immunological experiments, particularly for experiments on delayed type hypersensitivity. Its systematic chemical name is 4-ethoxymethylene-2-phenyloxazol-5-one and it is commercially available.

• 2-PHENYL-5-OXAZOLONE

Procedure. A mixture of 537 g. (3 moles) of hippuric acid (Note 1) and 1.6 l. (17 moles) of acetic anhydride is prepared in a 3-l. three-necked, round-bottomed flask fitted with a sealed stirrer, a reflux condenser with a drying tube, a thermometer, ...

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