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1. 関節リウマチにおける冠動脈疾患：疫学、病因、および危険因子 coronary artery disease in rheumatoid arthritis epidemiology pathogenesis and risk factors

English Journal

Stretchable electrochemical impedance sensors for intravascular detection of lipid-rich lesions in New Zealand White rabbits.

Cao H1, Yu F2, Zhao Y3, Scianmarello N3, Lee J1, Dai W4, Jen N1, Beebe T1, Li R1, Ebrahimi R5, Chang DS5, Mody FV5, Pacella J6, Tai YC3, Hsiai T7.Author information 1Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.2Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States.3Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, United States.4The Heart Institute of Good Samaritan Hospital, Los Angeles, CA, United States.5Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.6Division of Cardiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.7Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States. Electronic address: THsiai@mednet.ucla.edu.AbstractFlexible electronics have enabled catheter-based intravascular sensing. However, real-time interrogation of unstable plaque remains an unmet clinical challenge. Here, we demonstrate the feasibility of stretchable electrochemical impedance spectroscopy (EIS) sensors for endoluminal investigations in New Zealand White (NZW) rabbits on diet-induced hyperlipidemia. A parylene C (PAC)-based EIS sensor mounted on the surface of an inflatable silicone balloon affixed to the tip of an interrogating catheter was deployed (1) on the explants of NZW rabbit aorta for detection of lipid-rich atherosclerotic lesions, and (2) on live animals for demonstration of balloon inflation and EIS measurements. An input peak-to-peak AC voltage of 10 mV and sweeping-frequency from 300 kHz to 100 Hz were delivered to the endoluminal sites. Balloon inflation allowed EIS sensors to be in contact with endoluminal surface. In the oxidized low-density-lipoprotein (oxLDL)-rich lesions from explants of fat-fed rabbits, impedance magnitude increased significantly by 1.5-fold across the entire frequency band, and phase shifted ~5° at frequencies below 10 kHz. In the lesion-free sites of the normal diet-fed rabbits, impedance magnitude increased by 1.2-fold and phase shifted ~5° at frequencies above 30 kHz. Thus, we demonstrate the feasibility of stretchable intravascular EIS sensors for identification of lipid rich lesions, with a translational implication for detecting unstable lesions.
Biosensors & bioelectronics.Biosens Bioelectron.2014 Apr 15;54:610-6. doi: 10.1016/j.bios.2013.11.059. Epub 2013 Dec 1.
Flexible electronics have enabled catheter-based intravascular sensing. However, real-time interrogation of unstable plaque remains an unmet clinical challenge. Here, we demonstrate the feasibility of stretchable electrochemical impedance spectroscopy (EIS) sensors for endoluminal investigations in
PMID 24333932

Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis.

Tsou CY1, Chen CY, Zhao JF, Su KH, Lee HT, Lin SJ, Shyue SK, Hsiao SH, Lee TS.Author information 1Department of Physiology, National Yang-Ming University, Taipei, Taiwan.AbstractAIMS: Soluble guanylyl cyclase (sGC) is a key modulator in the regulation of vascular tone. However, its role and involving mechanism in cholesterol metabolism of macrophages and atherosclerosis remain unclear.
Acta physiologica (Oxford, England).Acta Physiol (Oxf).2014 Apr;210(4):799-810. doi: 10.1111/apha.12210. Epub 2013 Dec 27.
AIMS: Soluble guanylyl cyclase (sGC) is a key modulator in the regulation of vascular tone. However, its role and involving mechanism in cholesterol metabolism of macrophages and atherosclerosis remain unclear.METHODS: Oil red O staining, Dil-oxidized low-density lipoprotein (oxLDL)-binding assay an
PMID 24299003

LDL Oxidation and Its Association With Carotid Artery Intima-Media Thickness and Other Cardiovascular Risk Factors in a Sample of Spanish General Population.

Calmarza P1, Trejo JM, Lapresta C, López P.Author information 11Service of Clinical Biochemistry, Hospital Universitario Miguel Servet, Zaragoza, Spain.AbstractWe studied the association between oxidized low-density lipoproteins (OxLDLs) and early atherosclerosis, assessed by carotid artery intima-media thickness (cIMT), as well as with other known atherosclerosis risk factors in a sample of the general middle- and old-age population of Burgos (Spain). Circulating OxLDL showed a significant and independent association with the average cIMT of both carotid arteries but not with the absence or presence of ≥1 carotid atheroma plaques. Plasma OxLDL concentrations were associated with age, smoking, low-density lipoprotein-cholesterol, and triglycerides, independently of other variables. Our findings in an asymptomatic sample representative of the Spanish middle- and old-age population underscore the role of OxLDL in early atherosclerosis represented by the cIMT especially in older asymptomatic individuals, but this cannot be extended to more advanced atherosclerosis, represented by carotid plaques.
Angiology.Angiology.2014 Apr;65(4):357-62. doi: 10.1177/0003319713488639. Epub 2013 May 9.
We studied the association between oxidized low-density lipoproteins (OxLDLs) and early atherosclerosis, assessed by carotid artery intima-media thickness (cIMT), as well as with other known atherosclerosis risk factors in a sample of the general middle- and old-age population of Burgos (Spain). Cir
PMID 23661771

Japanese Journal

Recombinant domain 5 of β2-glycoprotein 1 inhibits the formation of a 7-ketocholesteryl-9-carboxynonanoate and β2-glycoprotein 1 complex

Zhang Yingbiao,Li Wenzhe,Chi Yan [他]
Journal of Biochemistry 149(1), 35-42, 2011-01
NAID 40017664412

Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox

NISHIZUKA Taichi,FUJITA Yoshiko,SATO Yuko,NAKANO Atushi,KAKINO Akemi,OHSHIMA Shunji,KANDA Tomomasa,YOSHIMOTO Ryo,SAWAMURA Tatsuya
Proceedings of the Japan Academy, Series B 87(3), 104-113, 2011
… Lectin-like oxidized LDL receptor-1 (LOX-1) is an endothelial receptor for oxidized LDL (oxLDL) and plays multiple roles in the development of cardiovascular diseases. … We screened more than 400 foodstuff extracts for identifying materials that inhibit oxLDL binding to LOX-1. …
NAID 130000669114

Visualization of Lipid Components in Human Coronary Plaques Using Color Fluorescence Angioscopy

UCHIDA Yasumi,UCHIDA Yasuto,KAMEDA Noriaki
Circulation journal : official journal of the Japanese Circulation Society 74(10), 2181-2186, 2010-09-25
… Background: If oxidized low-density lipoprotein (oxLDL), LDL, lysophosphatidylcholine (LPC) and apolipoprotein B (apoB) can be visualized simultaneously, their roles in the initiation, progression and destabilization of atherosclerotic plaques can be objectively evaluated. … (2) 50 excised human coronary plaques were classified by their autofluorescence into green, greenish-yellow and yellow, and the localization of oxLDL, LDL, LPC and apoB were investigated by color fluorescence angioscopy (CFA). …
NAID 10026640575