WordNet

relating to physical reality rather than with thoughts or the mind; "a concern with outward beauty rather than with inward reflections"
toward the outside; "move the needle further outward!" (同)outwards
electrical device that transforms alternating into direct current
a person who corrects or sets right; "a rectifier of prejudices"

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1. QT延長症候群の病態生理 pathophysiology of the long qt syndrome
2. 心血管疾患における低マグネシウム血症の意義 significance of hypomagnesemia in cardiovascular disease
3. 心不全および心筋症における心室性不整脈の病因 pathogenesis of ventricular arrhythmias in heart failure and cardiomyopathy
4. ドロネダロンの臨床使用 clinical uses of dronedarone
5. 心筋活動電位および抗不整脈剤の作用 myocardial action potential and action of antiarrhythmic drugs

Pro-arrhythmic action of autoantibodies against the second extracellular loop of β1-adrenoceptor and its underlying molecular mechanisms.

Zuo L1, Du Y2, Ma J3, Wang K2, Zhao Y2, Bai F4, Wu B1, Ma X5, Liu H6.
International journal of cardiology.Int J Cardiol.2015 Nov 1;198:251-8. doi: 10.1016/j.ijcard.2015.06.144. Epub 2015 Jul 2.
OBJECTIVES: The incidence of arrhythmia is associated with autoantibodies against the second extracellular loop of β1-adrenergic receptor (β1-AAbs). The current study was designed to determine the mechanisms by which arrhythmia experimentally might be induced by β1-AAbs.METHODS: Blood samples wer
PMID 26241168

Critical role of Casein kinase 2 in hepatitis C NS5A-mediated inhibition of Kv2.1 K+ channel function.

Clemens K1, Yeh CY1, Aizenman E2.
Neuroscience letters.Neurosci Lett.2015 Oct 17;609:48-52. doi: 10.1016/j.neulet.2015.10.021. [Epub ahead of print]
Inhibiting injury-induced increases in outward K+ currents is sufficient to block cell death in cortical neuronal injury models. It is now known that apoptosis is facilitated in hepatocytes by the same K+ channel as in cortical neurons, namely, the delayed rectifier K+ channel Kv2.1. The hepatitis C
PMID 26472706

Manipulation of KCNE2 expression modulates action potential duration and Ito and IK in rat and mouse ventricular myocytes.

Liu WJ1, Deng JX2, Wang G3, Gao KP3, Lin ZX3, Liu SY3, Wang YH3, Liu J3.
American journal of physiology. Heart and circulatory physiology.Am J Physiol Heart Circ Physiol.2015 Oct;309(8):H1288-302. doi: 10.1152/ajpheart.00757.2014. Epub 2015 Aug 21.
In heterologous expression systems, KCNE2 has been demonstrated to interact with multiple α-subunits of voltage-dependent cation channels and modulate their functions. However, the physiological and pathological roles of KCNE2 in cardiomyocytes are poorly understood. The present study aimed to inve
PMID 26297229

Direct Effects of Esmolol and Landiolol on Cardiac Function, Coronary Vasoactivity, and Ventricular Electrophysiology in Guinea-Pig Hearts

Shibata Shigehiro,Okamoto Yosuke,Endo Shigeatsu [他],ONO Kyoichi
Journal of pharmacological sciences 118(2), 255-265, 2012-02-20
… Esmolol also shortened the action potential duration (APD) in a concentration-dependent manner, an action maintained even when the delayed rectifier K+ … Moreover, esmolol inhibited both the inward rectifier K+ … current (ICaL) and increased the outward current dose-dependently. …
NAID 10030455076

Alternations of Transient Outward K+ Current (Ito) in Type 2 Diabetic Ventricular Cardiomyocytes

Intercalated Disc-Associated Protein mXinα Influences Surface Expresession of Ito and IK1 Currents in Ventricular Myocytes

Lin Cheng-I,Chan Fu-Chi,Cheng Chiao-Pei,Wu Kuo-Ho,Chen Yao-Chang,Hsu Chih-Hsiung,A. Gustafson-Wagner Elisabeth,Li-Chun Lin Jenny,Wang Qinchuan,Jung-Ching Lin Jim
Journal of Arrhythmia 27(Supplement), SS1_4, 2011
Mouse Xinα (mXinα) encodes a Xin repeat-containing, actin-binding protein localized to the intercalated disc (ICD). Ablation of mXinα progressively leads to disrupted ICD structure, cardiac hypertroph …
NAID 130002130107