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any of the salts of hydrobromic acid; formerly used as a sedative but now generally replaced by safer drugs

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〈U〉臭化物(鎮静剤・睡眠剤として用いる) / 〈C〉《話》陳腐なことば

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/30 19:34:52」(JST)

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Otilonium bromide is an antimuscarinic. It is used to relieve spasmodic pain of the gut especially irritable bowel syndrome^[1] and is sold under the trade name Spasmoctyl 40, and as Doralin in Greece.

References

^ http://www.grupounipharm.com/sites/default/files/DISMOX%20Inserto%20CORREGIDO%202011.%20Ingl%C3%A9s.pdf

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1. 代謝性アシドーシス以外の状況における血清アニオンギャップ serum anion gap in conditions other than metabolic acidosis
2. 12歳未満の小児における慢性喘息：初回評価および診断 asthma in children younger than 12 years rescue treatment for acute symptoms
3. 小児における喘息の急性増悪：救急外来によるマネージメント acute asthma exacerbations in children emergency department management
4. 成人における亜急性および慢性咳嗽の治療 treatment of subacute and chronic cough in adults
5. 小児における喘息の急性増悪：入院患者のマネージメント acute asthma exacerbations in children inpatient management

English Journal

Changes in the response to excitatory antagonists, agonists, and spasmolytic agents in circular colonic smooth muscle strips from patients with diverticulosis.

Alvarez-Berdugo D1, Espín F1, Arenas C2, López I1, Clavé P1,2,3, Gallego D2.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.Neurogastroenterol Motil.2015 Aug 24. doi: 10.1111/nmo.12659. [Epub ahead of print]
BACKGROUND: Colonic samples from asymptomatic diverticulosis (DS) patients presented enhanced electrical field stimulation (EFS)-contractions, in an earlier study of ours, suggesting increased endogenous responses. The aim of this study was to explore changes in excitatory neuromuscular transmission
PMID 26303606

Otilonium bromide as spasmolytic during endoscopic retrograde cholangiopancreatography.

Karahan Ö1, Sevinç B, Okuş A, Ay S, Aksoy N.
Surgical endoscopy.Surg Endosc.2015 Aug;29(8):2266-9. doi: 10.1007/s00464-014-3939-2. Epub 2014 Nov 1.
BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) is commonly used in both the diagnosis and the treatment of biliary and pancreatic disorders. The aim of this study is to evaluate the effects of OB usage during ERCP on duodenal motility, the tolerability of the procedure (by patient
PMID 25361657

Japanese Journal

Determination of the unstable drug otilonium bromide in human plasma by LC-ESI-MS and its application to a pharmacokinetic study

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 878(28), 2896-2900, 2010-10-15
NAID 10028042988

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★リンクテーブル★

リンク元	「オチロニウム」「臭化オチロニウム」
関連記事	「bromide」「otilonium」「bromides」

「オチロニウム」

Otilonium bromide
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	A03AB06 (WHO)
Identifiers
	IUPAC name N,N-Diethyl-N-methyl-2-(4-[2-(octyloxy)benzamido]benzoyloxy)ethanaminium bromide;
PubChem (CID)	72092
ChemSpider	65077
UNII	21HN3N72PV
KEGG	D07083
ECHA InfoCard	100.043.128
Chemical and physical data
Formula	C29H43BrN2O4
Molar mass	563.57 g/mol
3D model (Jmol)	Interactive image
	SMILES CCCCCCCCOC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)OCC[N+](C)(CC)CC.[Br-] ;
	InChI InChI=1S/C29H42N2O4.BrH/c1-5-8-9-10-11-14-22-34-27-16-13-12-15-26(27)28(32)30-25-19-17-24(18-20-25)29(33)35-23-21-31(4,6-2)7-3;/h12-13,15-20H,5-11,14,21-23H2,1-4H3;1H ; Key:VWZPIJGXYWHBOW-UHFFFAOYSA-N ;
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