オチロニウム
- 関
- otilonium bromide
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/06/10 09:46:50」(JST)
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Otilonium bromide
|
| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
| ATC code |
|
| Identifiers |
IUPAC name
- N,N-Diethyl-N-methyl-2-(4-[2-(octyloxy)benzamido]benzoyloxy)ethanaminium bromide
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| PubChem CID |
|
| ChemSpider |
|
| UNII |
|
| KEGG |
|
| ECHA InfoCard |
100.043.128 |
| Chemical and physical data |
| Formula |
C29H43BrN2O4 |
| Molar mass |
563.57 g/mol |
| 3D model (Jmol) |
|
SMILES
-
CCCCCCCCOC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)OCC[N+](C)(CC)CC.[Br-]
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InChI
-
InChI=1S/C29H42N2O4.BrH/c1-5-8-9-10-11-14-22-34-27-16-13-12-15-26(27)28(32)30-25-19-17-24(18-20-25)29(33)35-23-21-31(4,6-2)7-3;/h12-13,15-20H,5-11,14,21-23H2,1-4H3;1H N
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Key:VWZPIJGXYWHBOW-UHFFFAOYSA-N N
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| NY (what is this?) (verify) |
Otilonium bromide is an antimuscarinic. It is used to relieve spasmodic pain of the gut especially irritable bowel syndrome[1] and is sold under the trade name Spasmoctyl 40, and as Doralin in Greece.
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Drugs for functional gastrointestinal disorders (A03)
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Drugs for
functional
bowel disorders |
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Antimuscarinics
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Tertiary
amino group
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- Oxyphencyclimine
- Camylofin
- Mebeverine
- Trimebutine
- Rociverine
- Dicycloverine
- Dihexyverine
- Difemerine
- Piperidolate
|
Quaternary
ammonium
compounds |
- Benzilone
- Mepenzolate
- Pipenzolate
- Glycopyrronium
- Oxyphenonium
- Penthienate
- Methantheline
- Propantheline
- Otilonium
- Tridihexethyl
- Isopropamide
- Hexocyclium
- Poldine
- Bevonium
- Diphemanil
- Tiemonium
- Prifinium
- Timepidium
- Fenpiverinium
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|
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Phosphodiesterase
inhibitors
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- Papaverine
- Drotaverine
- Moxaverine
|
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Acting on
serotonin receptors
|
- 5-HT3 antagonists
- 5-HT4 agonists
- Mosapride
- Prucalopride
- Tegaserod
|
|
Other
|
- Alverine
- Caroverine
- Chlorbenzoxamine
- Diisopromine
- Dimethylaminopropionylphenothiazine
- Fenpiprane
- Fenoverine
- Idanpramine
- Isometheptene
- Phloroglucinol
- Pinaverium
- Proxazole
- Silicones
- Tiropramide
- Trepibutone
- Trimethyldiphenylpropylamine
|
|
Belladonna
and derivatives
(antimuscarinics) |
- Tertiary amines: Atropine
- Hyoscyamine
- Quaternary ammonium compounds:
- Scopolamine
- Butylscopolamine
- Methylscopolamine
- Methylatropine
- Fentonium
- Cimetropium bromide
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| Propulsives |
- Primarily dopamine antagonists
- Metoclopramide/Bromopride
- Clebopride
- Domperidone
- Alizapride
- 5-HT4 agonists
|
References
- ^ http://www.grupounipharm.com/sites/default/files/DISMOX%20Inserto%20CORREGIDO%202011.%20Ingl%C3%A9s.pdf
UpToDate Contents
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English Journal
- Changes in the response to excitatory antagonists, agonists, and spasmolytic agents in circular colonic smooth muscle strips from patients with diverticulosis.
- Alvarez-Berdugo D1, Espín F1, Arenas C2, López I1, Clavé P1,2,3, Gallego D2.
- Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.Neurogastroenterol Motil.2015 Nov;27(11):1600-12. doi: 10.1111/nmo.12659. Epub 2015 Aug 24.
- BACKGROUND: Colonic samples from asymptomatic diverticulosis (DS) patients presented enhanced electrical field stimulation (EFS)-contractions, in an earlier study of ours, suggesting increased endogenous responses. The aim of this study was to explore changes in excitatory neuromuscular transmission
- PMID 26303606
- Pharmacologic Agents for Chronic Diarrhea.
- Lee KJ1.
- Intestinal research.Intest Res.2015 Oct;13(4):306-12. doi: 10.5217/ir.2015.13.4.306. Epub 2015 Oct 15.
- Chronic diarrhea is usually associated with a number of non-infectious causes. When definitive treatment is unavailable, symptomatic drug therapy is indicated. Pharmacologic agents for chronic diarrhea include loperamide, 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists, diosmectite, cholesty
- PMID 26576135
- Otilonium bromide as spasmolytic during endoscopic retrograde cholangiopancreatography.
- Karahan Ö1, Sevinç B, Okuş A, Ay S, Aksoy N.
- Surgical endoscopy.Surg Endosc.2015 Aug;29(8):2266-9. doi: 10.1007/s00464-014-3939-2. Epub 2014 Nov 1.
- BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) is commonly used in both the diagnosis and the treatment of biliary and pancreatic disorders. The aim of this study is to evaluate the effects of OB usage during ERCP on duodenal motility, the tolerability of the procedure (by patient
- PMID 25361657
Japanese Journal
- Determination of the unstable drug otilonium bromide in human plasma by LC-ESI-MS and its application to a pharmacokinetic study
- ZHAO Yan-rong,DING LI,FAN Hong-wei,YU Yong,QI Xie-Min,LENG Ye,RAO Ya-kun
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 878(28), 2896-2900, 2010-10-15
- NAID 10028042988
Related Links
- Whole-cell Ba2+ currents (IBa) through Ca2+ channels of voltage-clamped chromaffin cells were blocked by otilonium with an IC50 of 6.4 microM. Octylonium bromide (SP63) inhibited the secretory responses induced by 10 s pulses of 50 microM DMPP with an IC50 of 7.4 nM [2].
- Otilonium Bromideの服用時に倦怠感、目まい、高血圧や頭痛の副作用が現れると、車や重機を運転するのに危険が生じる可能性があります。さらに、眠気、目まい、血圧が下がるような症状が出れば、車の運転を避けた方がいい。
- Otilonium Bromide | C29H43BrN2O4 | CID 72092 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ...
★リンクテーブル★
[★]
- 英
- otilonium、otilonium bromide
- 関
- 臭化オチロニウム