放射線骨壊死
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/10/29 11:28:33」(JST)
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MRI showing osteoradionecrosis in the cervical vertebrae following radiotherapy for laryngeal cancer.
Osteoradionecrosis is a possible complication following radiotherapy. Irradiation of bones causes damage to osteocytes and impairs the blood supply. The affected hard tissues become hypovascular (reduced number of blood vessels), hypocellular (reduced number of cells) and hypoxic (low levels of oxygen). Osteoradionecrosis is the term for when the area of bone does not heal from this damage. This usually occurs in the mandible, and causes chronic pain and surface ulceration. Prevention of osteradionecrosis is part of the reason why all teeth of questionable prognosis are removed before the start of a course of radiotherapy.[1]
References[edit]
- ^ Bouquot, Brad W. Neville , Douglas D. Damm, Carl M. Allen, Jerry E. (2002). Oral & maxillofacial pathology (2. ed. ed.). Philadelphia: W.B. Saunders. p. 263. ISBN 0-7216-9003-3.
Oral and maxillofacial pathology (K06, K11–K14, 523, 527–529)
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Lips |
Cheilitis (Angular · Actinic · Plasma cell) · Herpes labialis · Trumpeter's wart
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Tongue |
Glossitis (Geographic tongue · Median rhomboid glossitis · Transient lingual papillitis) · Fissured tongue · Black hairy tongue · Caviar tongue · Macroglossia · Hypoglossia · Ankyloglossia · Crenated tongue · Osseous choristoma of the tongue
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Oral mucosa |
Oral ulceration · Stomatitis (Aphthous · Herpetic · Nicotinic · Denture-related) · Erythroplakia · Leukoplakia · Hairy leukoplakia · Leukoedema · White sponge nevus · Burning mouth syndrome · Fordyce spots · Lichen planus · Morsicatio buccarum · Linea alba · Behçet syndrome · Angina bullosa haemorrhagica · Melanocytic oral lesion · Oral melanosis · Recurrent intraoral herpes simplex infection · Plasmoacanthoma · Oral florid papillomatosis · Oral candidiasis
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Teeth
(pulp, dentin, enamel) |
Dental caries · Dentin hypersensitivity · Pulpitis · Pulpal necrosis · Pulp polyp · Pulp calcification · Fluorosis · Hypodontia · Hyperdontia · Macrodontia · Microdontia · Dilaceration · Taurodontism · Fusion · Gemination · Concrescence · Amelogenesis imperfecta · Dentinogenesis imperfecta · Dentinal dysplasia · Regional odontodysplasia · Attrition · Abrasion · Erosion · Resorption · Premature eruption · Delayed eruption · Impaction · Odontome (Dens in dente) · Odontogenic tumors (Keratocystic odontogenic tumour)
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Periodontium
(gingiva, Periodontal ligament,
cementum, alveolus)
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Gingivitis (Desquamative gingivitis · Plasma cell gingivitis) · Epulis (Pyogenic granuloma) · Gingival overgrowth · Periodontitis · Pericoronitis · Necrotizing periodontal diseases (Acute necrotizing ulcerative gingivitis · Noma) · Periodontal abscess · Hypercementosis · Hypocementosis
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Periapaical, mandibular
and maxillary hard tissues |
Periapical periodontitis · Periapical abscess · Alveolar osteitis · Osteoradionecrosis · Torus palatinus · Torus mandibularis · Cherubism · Paget's disease of bone · Mandibular fracture · Stafne defect · Osteomyelitis of the jaws
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Temporomandibular joints and
muscles of mastication |
Temporomandibular joint dysfunction · Bruxism · Mandibular dislocation
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Salivary glands |
Sialadenitis (Parotitis) · Sialolithiasis · Mucous cyst of the oral mucosa (Ranula) · Sjögren's syndrome · Sialocele · Benign lymphoepithelial lesion · Necrotizing sialometaplasia · Salivary gland neoplasms (Pleomorphic adenoma)
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Orofacial soft tissues |
Ludwig's angina · Cutaneous sinus of dental origin · Cystic hygroma · Velopharyngeal inadequacy · Actinomycosis · Orofacial granulomatosis · Melkersson–Rosenthal syndrome · Pyostomatitis vegetans · Oral Crohn's disease · Epulis fissuratum · Perioral dermatitis
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noco/cofa (c)/cogi/tumr, sysi
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UpToDate Contents
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English Journal
- Dosimetric distribution to the tooth-bearing regions of the mandible following intensity-modulated radiation therapy for base of tongue cancer.
- Hansen HJ, Maritim B, Bohle GC 3rd, Lee NY, Huryn JM, Estilo CL.SourceFellow, Dental Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, and Assistant Professor, Division of Oral & Maxillofacial Surgery & Dentistry, Department of Surgery, Weill Cornell Medical College/New York Presbyterian Hospital, New York, New York.
- Oral surgery, oral medicine, oral pathology and oral radiology.Oral Surg Oral Med Oral Pathol Oral Radiol.2012 Aug;114(2):e50-4. Epub 2012 May 12.
- OBJECTIVES: Osteoradionecrosis is a significant complication following head and neck radiotherapy. The purpose of this study was to determine the intensity-modulated radiation therapy (IMRT) dosages delivered to the tooth-bearing regions of the mandible.STUDY DESIGN: A total of 28 patients with base
- PMID 22769422
- Compliance with fluoride custom trays in irradiated head and neck cancer patients.
- Thariat J, Ramus L, Darcourt V, Marcy PY, Guevara N, Odin G, Poissonnet G, Castillo L, Ali AM, Righini C.SourceDepartment of Radiation Oncology/Institut Universitaire de la Face et du Cou fo J thariat, Cancer Center Antoine-Lacassagne, University Nice Sophia-Antipolis, 33 Av. Valombrose, 06189, NICE Cedex 2, France, jthariat@hotmail.com.
- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.Support Care Cancer.2012 Aug;20(8):1811-4. Epub 2011 Sep 25.
- PURPOSE: The purpose of this study is to assess compliance with fluoride gel custom trays in irradiated head and neck cancer patients.METHODS AND MATERIALS: One hundred fifty-five consecutive patients on remission following radiation therapy of head and neck cancers were assessed retrospectively for
- PMID 21947441
Japanese Journal
- Low-dose-rate Interstitial Brachytherapy Preserves Good Quality of Life in Buccal Mucosa Cancer Patients
- TAYIER Abulajiang,HAYASHI Keiji,YOSHIMURA Ryoichi
- Journal of radiation research 52(5), 655-659, 2011-09-16
- … Osteoradionecrosis was diagnosed in 8 patients, but only one patient required surgical treatment. …
- NAID 10029456090
- Ionising irradiation-induced inhibition of differentiation of C3H10T1/2 cells to the osteoblastic lineage.
- Sakurai Tomonori,Ito Michitoshi,Mikamoto Takahiro,Ohshio Ryousuke,Miyakoshi Junji
- International journal of radiation biology 87(5), 447-452, 2011-05
- … [Purpose]:Previous studies using mouse osteoblast derived MC3T3-E1 and mouse myoblast derived C2C12 cells have not completely explained the mechanisms responsible for osteoradionecrosis. … Thus, the aim of this study was to advance the in vitro experimental approaches for investigations of osteoradionecrosis. …
- NAID 120004225592
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- Hyperbaric Oxygen Therapy (HBO) has proven to be effective, though it has been slow to be accepted universally. More control studies are needed to confirm the effectiveness of HBO Therapy, however the proximity and scarcity of ...
- osteoradionecrosis /os·teo·ra·dio·ne·cro·sis/ (-ra″de-o-nĕ-kro´sis) necrosis of bone as a result of exposure to radiation. os·te·o·ra·di·o·ne·cro·sis (s t--r d--n-kr s s) n. Necrosis of bone caused by exposure to ionizing radiation. ...
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