osteomalacia

出典: meddic

骨軟化症

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「abnormal softening of bones caused by deficiencies of phosphorus or calcium or vitamin D」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/24 16:45:22」(JST)

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英文文献

  • Bilateral femoral neck insufficiency fractures secondary to vitamin D deficiency and concurrent corticosteroid use-a case report.
  • Carter T1, Nutt J, Simons A.Author information 1Department of Orthogeriatrics, Birmingham Heartlands Hospital, Birmingham, UK, tjcarter@doctors.org.uk.AbstractWe present a rare case of a 67-year-old Indian female who was found to have bilateral insufficiency of the neck of femur fractures secondary to osteomalacia from vitamin D deficiency, with her symptoms exacerbated by a course of oral steroids prescribed for suspected polymyalgia rheumatica.
  • Archives of osteoporosis.Arch Osteoporos.2014 Dec;9(1):172. doi: 10.1007/s11657-014-0172-5. Epub 2014 Feb 11.
  • We present a rare case of a 67-year-old Indian female who was found to have bilateral insufficiency of the neck of femur fractures secondary to osteomalacia from vitamin D deficiency, with her symptoms exacerbated by a course of oral steroids prescribed for suspected polymyalgia rheumatica.INTRODUCT
  • PMID 24515953
  • Severe hypocalcemia after denosumab in a patient with acquired Fanconi syndrome.
  • Shafqat H1, Alquadan KF, Olszewski AJ.Author information 1Memorial Hospital of Rhode Island, 111 Brewster St., Pawtucket, RI, 02860, USA.AbstractWe report the case of a 48-year-old man with acquired Fanconi syndrome due to IgG-kappa monoclonal gammopathy, who received a single dose of denosumab 60 mg for secondary prevention of skeletal fractures, in conjunction with oral calcium and vitamin D supplementation. The treatment was complicated with a severe, symptomatic hypocalcemia occurring 1 month after the injection and necessitating 4 weeks of intravenous calcium gluconate therapy. Similarly to bisphosphonates, inhibitors of the receptor activator of nuclear factor kappa-B ligand may not be appropriate for the treatment of acquired Fanconi syndrome and other forms of osteomalacia regardless of the degree of renal insufficiency and vitamin D levels. Clinicians should carefully interpret the radiographic and bone densitometry results in light of diverse mechanisms of bone demineralization and potential dependence of calcium homeostasis on high bone turnover.
  • Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.Osteoporos Int.2014 Mar;25(3):1187-90. doi: 10.1007/s00198-013-2533-0. Epub 2013 Oct 25.
  • We report the case of a 48-year-old man with acquired Fanconi syndrome due to IgG-kappa monoclonal gammopathy, who received a single dose of denosumab 60 mg for secondary prevention of skeletal fractures, in conjunction with oral calcium and vitamin D supplementation. The treatment was complicated
  • PMID 24158473
  • Hypophosphatemic rickets due to perturbations in renal tubular function.
  • Penido MG1, Alon US.Author information 1Pediatric Nephrology Unit, Clinics Hospital, School of Medicine, Federal University of Minas Gerais, Av. Professor Alfredo Balena, 190, CEP, 30130100, Belo Horizonte, MG, Brazil, mariagorettipenido@gmail.com.AbstractThe common denominator for all types of rickets is hypophosphatemia, leading to inadequate supply of the mineral to the growing bone. Hypophosphatemia can result from insufficient uptake of the mineral from the gut or its disproportionate losses in the kidney, the latter being caused by either tubular abnormalities per se or the effect on the tubule of circulating factors like fibroblast growth factor-23 and parathyroid hormone (PTH). High serum levels of the latter result in most cases from abnormalities in vitamin D metabolism which lead to decreased calcium absorption in the gut and hypocalcemia, triggering PTH secretion. Rickets is a disorder of the growth plate and hence pediatric by definition. However, it is important to recognize that the effect of hypophosphatemia on other parts of the skeleton results in osteomalacia in both children and adults. This review addresses the etiology, pathophysiologic mechanisms, clinical manifestations and treatment of entities associated with hypophosphatemic rickets due to perturbations in renal tubular function.
  • Pediatric nephrology (Berlin, Germany).Pediatr Nephrol.2014 Mar;29(3):361-73. doi: 10.1007/s00467-013-2466-z. Epub 2013 May 1.
  • The common denominator for all types of rickets is hypophosphatemia, leading to inadequate supply of the mineral to the growing bone. Hypophosphatemia can result from insufficient uptake of the mineral from the gut or its disproportionate losses in the kidney, the latter being caused by either tubul
  • PMID 23636577

和文文献

  • 代謝性骨・関節疾患 (特集 高齢者の骨・関節疾患 : 転倒予防に向けての取り組み) -- (高齢者の主な骨・関節疾患の病態・診断・治療)
  • 今月の症例 抗B型肝炎ウイルス薬のアデフォビルにより薬剤性Fanconi症候群および低P血症性骨軟化症をきたした1例
  • 廣瀬 和俊,乳原 善文,平松 里佳子 [他]
  • 日本内科学会雑誌 103(6), 1388-1390, 2014-06-10
  • NAID 40020123532
  • 症例報告 アデホビル長期投与中にFanconi症候群による低リン血性骨軟化症を発症したB型慢性肝炎の1例
  • 石川 和真,宮西 浩嗣,保木 寿文 [他]
  • 肝臓 55(3), 162-169, 2014-03
  • NAID 40020025392

関連リンク

Learn about Osteomalacia on Healthgrades.com, including information on symptoms, causes and treatments. ... Introduction What is osteomalacia? Osteomalacia is a disease that causes an adult’s bones to soften, resulting in ...
osteomalacia /os·teo·ma·la·cia/ (os″te-o-mah-la´shah) inadequate or delayed mineralization of osteoid in mature cortical and spongy bone; it is the adult equivalent of rickets and accompanies that disorder in children.osteomala´cic ...

関連画像

OsteomalaciaStage IV Lung Cancer in the Elderly Part 2 Vitamin D Food Sources Versus Vitamin D Vitamin D signalling pathways in cancer Osteomalacia - Causes, Symptoms and Disease: Osteomalacia


★リンクテーブル★
リンク元骨軟化症
拡張検索postgastrectomy osteomalacia

骨軟化症」

  [★]

osteomalacia
(小児のでは)くる病骨粗鬆症
  • 骨基質へのカルシウム沈着が障害され、類骨が多く生じる病態。
  • 原因:ビタミンDの作用低下、リンの欠乏。 ← 甲状腺機能低下症のように低カルシウム血症、高リン血症では本症が生じるのではなく、異所性石灰化がみられるらしい



postgastrectomy osteomalacia」

  [★] 胃切除後骨軟化症




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